Diabetes mellitus type 1 (DM1) is an autoimmune disease with beta-cell destruction and absolute insulin deficiency. The most effective therapy of DM1 is lifelong vicarous insulinterapy. Unfortunately, there is no successful methods of prophylaxis and treatment of DM1. In this review we will discuss results of modern trials of primary, secondary and tertiary prophylaxis of DM1.

This article proposes a method of improving the classification of postoperative complications (postpericardiotomic syndrome and low ejection fraction) on the basis of regularized discriminant analysis applied to several sub-groups with more favorable classification properties. Logical operations and finite linear combinations over F₂ in set of factors are used for identification of recent. Prediction is obtained by averaging of co-incident discriminant functions and by frequency of their correct classification.

Purpose. To assess the value of gated blood pool SPECT in assessment of right ventricle (RV) contractility in patients with rheumatic mitral stenosis (MS). Materials and methods. The study included 20 patients (mean age 54,2 ± 8,22 years) with rheumatic MS, 13 patients were examined before and after correction of mitral defect. All patients underwent gated blood pool SPECT before and after mitral valve replacement. Results. All patients with mitral stenosis show fixed RV regional wall contractility reduction. Patients with MS, in comparison with control group patients show significantly lower values of EF, the MSI and the MFR/3, SV, and larger values of RV EDV. Mitral valve replacement realized in statistically significant decrease of ESV, increasing of MSI and RV EF. The size of the right atrium, measured by blood pool SPECT, was significantly increased in patients with MS, and significantly decreased after mitral valve replacement. Conclusion. Gated blood pool SPECT can be used for noninvasive assessment of functional status of the right ventricle in patients with rheumatic mitral stenosis.

Objective. To determine new predictors of an efficiency of cardiac resynchronization therapy (CRT) using nuclear imaging techniques. Design and methods. 75 patients with dilated cardiomyopathy and chronic heart failure were included in the study. Myocardial perfusion imaging with 99mТс-MIBI was performed in all patients before CRT. For assessment of myocardial metabolism 63 patients were referred to cardiac scintigraphy with 123I-BMIPP before CRT and 12 patients underwent positron emission tomography with 18F-FDG twice (before and 6 months after CRT). Echocardiography was carried out before and 6 months after CRT for estimate left ventricular (LV) function. Results. Based on the reduction of end systolic LV volume > 15% 6 months after CRT all patients were divided into two groups: responders (n = 39) and nonresponders (n = 24). ROC curve analysis showed the highest predictive values for the following parameters: the size of metabolic defect (sensitivity - 77,8 %, specificity - 66,7 %, the optimal cut off value - 7,35 %), the calculated value of the end systolic LV volume (sensitivity - 87,5 %, specificity - 100 %, the optimal cut off value - 34,02), and the septal-to-lateral ratio according to the 18F-FDG-PET results (sensitivity - 100 %, specificity - 80 %, the optimal cut off value - 0,67). Conclusion. The data of cardiac scintigraphy and positron emission tomography are useful to predict an efficiency of cardiac resynchronization therapy.

This publishing is the particular matter to help for a performance of perfusion of the isolated heart by Langendorff and Neely methods. The publishing represents and describes the fundamental plan of an installation for the perfusion of the isolated heart by these methods, determines a specific succession of action while executing a perfusion (by current experience of these authors) and explores possibilities of using the model of perfusion of the isolated heart in the scientific research.

Background. Spinal stroke is accompanied by rude, persistent neurological and physical disorders. Modeling of ischemia allows to explore the pathophysiological processes in the spinal cord and improve treatment outcomes. Objective. To develop a model of spinal cord ischemia in rats by aortic occlusion below renal arteries. Methods. We performed ligation of the abdominal aorta below the renal arteries in Wistar rats and watched the neurological deficit after 48 hours. Then we carried out histological examination of sections of the lumbosacral spinal cord to detect ischemic changes in neurons. Results. We revealed the predominance of hyperchromatic neurons and shadow-cells in spinal cord of experimental animals. Glial reaction is also revealed. These changes indicates an irreversible, coagulation stage of spinal cord ischemia. Conclusions. 1) Occlusion of the aorta below the renal arteries in Wistar rats leads to ischemic lesions on the lumbar level of spinal cord. Thus, the occlusion of the aorta below the renal arteries of Wistar rats may be viewed as a model of spinal ischemic stroke in rats. 2) This model allows to model incomplete spinal ischemia with diffuse disease of neurons of the lumbosacral spinal cord.

This review summarizes current understanding of the function of blood vessels, valuation methodologies the vascular wall, the adaptive changes that occur in it during normal pregnancy.

A case of pemphigus vegetans in 34 years old pregnant woman. We described clinical sings and medical treatment of the disease against the background of pregnancy.