СТИМУЛЯЦИЯ БЛУЖДАЮЩЕГО НЕРВА В КАРДИОЛОГИИ
https://doi.org/10.18705/2311-4495-2017-4-2-6-16
Аннотация
В статье проводится обзор ключевых исследований по стимуляции блуждающего нерва в области кардиологии.
Стимуляция блуждающего нерва влияет на нейронные цепи внутренних и наружных сердечных сплетений, усиливающее парасимпатическое влияние. Благодаря такому воздействию в различных экспериментальных и клинических исследованиях достигался положительный терапевтический эффект в лечении наджелудочковых и желудочковых нарушений ритма, сердечной недостаточности, инфаркта миокарда.
Было показано, что стимуляция блуждающего нерва приводит к уменьшению количества эпизодов фибрилляции предсердий, снижает риск возникновения фибрилляции желудочков и обладает протективным эффектом в отношении желудочковых тахикардий. В настоящее время проводятся клинические исследования по стимуляции блуждающего нерва, промежуточные результаты которых отражены в статье.
Об авторах
Владимир Александрович Сыровнев
"Федеральный медицинский исследовательский центр имени В. А. Алмазова" Министерства здравоохранения Российской Федерации, Санкт-Петербург
Россия
Россия
ординатор по курсу «кардиология»
ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341
Дмитрий Сергеевич Лебедев
"Федеральный медицинский исследовательский центр имени В. А. Алмазова" Министерства здравоохранения Российской Федерации, Санкт-Петербург
Россия
Россия
д.м.н., проф. РАН, руководитель НКО аритмологии
Евгений Николаевич Михайлов
"Федеральный медицинский исследовательский центр имени В. А. Алмазова" Министерства здравоохранения Российской Федерации, Санкт-Петербург
Россия
д. м. н., заведующий НИЛ нейромодуляции, доцент кафедры хирургических болезней
Россия
д. м. н., заведующий НИЛ нейромодуляции, доцент кафедры хирургических болезней
Список литературы
1. Михайлов Е.Н., Лебедев Д.С., Вандер М.А., Федотов П.А., Пальцев А.В., Черебилло В.Ю., Ситникова М.Ю., Шляхто Е.В.: Электрическая стимуляция спинного мозга при хронической сердечной недостаточности. Трансляционная медицина. 2015. № 5 (34). С. 104-112.
2. Benditt DG, Iskos D, Sakaguchi S.: Autonomic nervous system and cardiac arrhythmias. In. Electrophysiological Disorders of the Heart. (eds. Saksena S and Camm AJ) Philadelphia, PA, Elsevier Churchill Livingstone 2005. p. 49-67.
3. Buch AN, Coote JH, Townend JN.: Mortality, cardiac vagal control and physical training–what’s the link? Exp Physiol. 2002; 87: 423–435.
4. Kinugawa T, Dibner-Dunlap ME.: Altered vagal and sympathetic control of heart rate in left ventricular dysfunction and heart failure. Am J Physiol. 1995; 268: R317–R323.
5. Sinelnikov R., Sinelnikov J. Atlas of Human Anatomy. In: Volume 4. Moscow: Medicina, 1996: 133-139. [Синельников Р.Д., Синельников Я.Р. Атлас Анатомии Человека, том 4. М.: Медицина 1996: 133-139.]
6. Peng-Sheng Chen Lan S. Chen and Shien-Fong Lin. Neural Activity and Atrial Tachyarrhythmias. In: Douglas P. Zipes MD and José Jalife MD: Cardiac Electrophysiology From Cell to Bedside. Sixth Edition. 40, 399-407.
7. John E. Hall PhD., Arthur C. Guyton, M.D. Rhythmical excitation of the heart. In: Guyton and Hall Textbook of Medical Physiology, 13th Edition. 10, 107-113.
8. Randall DC, Brown DR, McGuirt AS, Thompson GW, Armour JA & Ardell JL.: Interactions within the intrinsic cardiac nervous system contribute to chronotropic regulation. Am J Physiol Regul Integr Comp Physiol 2003; 285: R1066–R1075.
9. Armour JA, Collier K, Kimber G & Ardell JL.: Differential selectivity of cardiac neurons in separate intrathoracic ganglia. Am J Physiol Regul Integr Comp Physiol 1998. 274, R939–R949.
10. Armour JA.: Potential clinical relevance of the ‘little brain’ on the mammalian heart. Experimental Physiology, Volume 93, Issue 2, February 2008, Pages 165–176.
11. Masahiro Ogawa MD, PhD, Zhou S, Tan AY, Song J, Gholmieh G, Fishbein MC, Luo H, Siegel RJ, Karagueuzian HS, Chen LS, Lin SF, Chen PS.: Left Stellate Ganglion and Vagal Nerve Activity and Cardiac Arrhythmias in Ambulatory Dogs With Pacing-Induced Congestive Heart Failurе. J Am Coll Cardiol. 2007 Jul 24;50(4):335-43.
12. Alex Y. Tan, Shengmei Zhou, Masahiro Ogawa, Juan Song, Matthew Chu, Hongmei Li, Michael C. Fishbein, Shien-Fong Lin, Lan S. Chen and Peng-Sheng Chen.: Neural Mechanisms of Paroxysmal Atrial Fibrillation and Paroxysmal Atrial Tachycardia in Ambulatory Canines. Circulation, August 26, 2008, Volume 118, Issue 9
13. Shen MJ, Shinohara T, Park HW, et al.: Continuous low-level vagus nerve stimulation reduces stellate ganglion nerve activity and paroxysmal atrial tachyarrhythmias in ambulatory canines. Circulation 123:2204–2212, 2011
14. Burashnikov A, Antzelevitch C.: Reinduction of atrial fibrillation immediately after termination of the arrhythmia is mediated by late phase 3 early afterdepolarization-induced triggered activity. Circulation 2003;107:2355–60.
15. Patterson E, Lazzara R, Szabo B, et al.: Sodium-calcium exchange initiated by the Ca2+ transient: an arrhythmia trigger within pulmonary veins. J Am Coll Cardiol 2006;47:1196–206.
16. Zhang Y1, Scherlag BJ, Lu Z, Niu GD, Yamanashi WS, Hogan C, Fields J, Ghias M, Lazzara R, Jackman WM, Po S.: Comparison of atrial fibrillation inducibility by electrical stimulation of either the extrinsic or the intrinsic autonomic nervous systems. J Interv Card Electrophysiol. 2009 Jan;24(1):5-10.
17. Sharifov OF, Fedorov VV, Beloshapko GG, Glukhov AV, Yushmanova AV, Rosenshtraukh LV.: Roles of adrenergic and cholinergic stimulation in spontaneous atrial fibrillation in dogs. J Am Coll Cardiol 2004;43:483–90.
18. Inoue H, Zipes DP.: Changes in atrial and ventricular refractoriness and in atrioventricular nodal conduction produced by combinations of vagal and sympathetic stimulation that result in a constant spontaneous sinus cycle length. Circ Res 1987;60:942–51.
19. Park HW, Shen MJ, Han S, et al.: Neural control of ventricular rate in ambulatory dogs with pacing-induced sustained atrial fibrillation. Circ Arrhythm Electrophysiol 5:571–580, 2012
20. I.M. Ali, MD, C.K. Butler, MD, J.A. Armour, MD, PhD, D.A. Murphy, MD.: Modification of supraventricular tachyarrhythmias by stimulating atrial neurons, The Annals of Thoracic Surgery, Volume 50, Issue 2, August 1990, Pages 251-256
21. Shuyan Li, MD; Benjamin J. Scherlag, PhD; Lilei Yu, MD; Xia Sheng, MD; Ying Zhang, MD, PhD; Reza Ali, MD; Yumei Dong, MD; Muhammad Ghias, MD; Sunny S. Po, MD, PhD.: Low-Level Vagosympathetic Stimulation. A Paradox and Potential New Modality for the Treatment of Focal Atrial Fibrillation. Circ Arrhythm Electrophysiol, 2009, DOI: 10.1161/CIRCEP.109.868331
22. Stavros Stavrakis, MD, PhD; Mary Beth Humphrey, MD, PhD†; Benjamin J. Scherlag, PhD et al.: Low-level transcutaneous electrical vagus nerve stimulation suppresses atrial fibrillation. J Am Coll Cardiol. 2015;65(9):867-875. doi:10.1016/j.jacc.2014.12.026.
23. Zhou Q., Hou Y., and Yang S.: A meta-analysis of the comparative efficacy of ablation for atrial fibrillation with and without ablation of the ganglionated plexi. Pacing Clin Electrophysiol 2011; 34: pp. 1687-1694
24. Po SS, Nakagawa H, Jackman WM.: Localization of left atrial ganglionated plexi in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2009 Oct.
25. Kittiya Thunsiri, Krekwit Shinlapawittayatorn, Kreokkiat Chinda, Siripong Palee, Sirirat Surinkaew, Siriporn C. Chattipakorn, Bruce H. KenKnight and Nipon Chattipakorn.: Application of vagus nerve stimulation from the onset of ventricular fibrillation to post-shock period improves defibrillation efficacy. International Journal of Cardiology, 2014-10-20, Volume 176, Issue 3, Pages 1030-1032
26. Ng G.A., Brack K.E., Patel V.H., and Coote J.H.: Autonomic modulation of electrical restitution, alternans and ventricular fibrillation initiation in the isolated heart. Cardiovasc Res 2007; 73: pp. 750-760
27. Murakawa Y., Yamashita T., Ajiki K., Hayami N., Omata M., and Nagai R.: Effect of cervical vagal nerve stimulation on defibrillation energy: a possible adjunct to efficient defibrillation. Jpn Heart J 2003; 44: pp. 91-100
28. Brack KE, Patel VH, Mantravadi R, Coote JH, Ng GA.: Direct evidence of nitric oxide release from neuronal nitric oxide synthase activation in the left ventricle as a result of cervical vagus nerve stimulation. J Physiol 2009; 587:3045-3054.
29. Vanoli E, De Ferrari GM, Stramba-Badiale M, Hull SS Jr, Foreman RD, Schwartz PJ.: Vagal stimulation and prevention of sudden death in conscious dogs with a healed myocardial infarction. Circ Res 1991; 68:1471–1481
30. Takahashi N1, Ito M, Iwao T, Ohie T, Yonemochi H, Nakagawa M, Saikawa T, Sakata T.: Vagal modulation of ventricular tachyarrhythmias induced by left ansae subclaviae stimulation in rabbits. Jpn Heart J. 1998 Jul; 39(4):503-11.
31. Kieran E. Brack, John H. Coote, G. André Ng.: Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation. Cardiovascular research. May 2011. рр. 437-446
32. Писклова А.В., Афанасьев С.А., Антонченко И.В.: Немедикаментозная коррекция вегетативного тонуса в лечении желудочковой экстрасистолии у пациентов с ишемической болезнью сердца. Вестник аритмологии. – 2006. - №. 43. – С. 23-27.
33. Wang, Zhuo PhD *; Yu, Lilei MD, PhD *; Wang, Songyun MD; Huang, Bing MD; Liao, Kai MD; Saren, Gaowa MD; Tan, Tuantuan PhD; Jiang, Hong MD.: Chronic Intermittent Low-Level Transcutaneous Electrical Stimulation of Auricular Branch of Vagus Nerve Improves Left Ventricular Remodeling in Conscious Dogs With Healed Myocardial Infarction. Circulation: Heart Failure. November 2014. 7(6):1014-1021,.
34. Sabbah HN, Imai M, Zaretsky A, et al.: Therapy with vagus nerve electrical stimulation combined with beta-blockade improves left ventricular systolic function in dogs with heart failure beyond that seen with beta-blockade alone. Eur J Heart Fail Supplements 2007; 6(suppl):114.
35. Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K.: Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 2004;109:120–4.
36. Zheng C1, Li M, Inagaki M, Kawada T, Sunagawa K, Sugimachi M.: Vagal stimulation markedly suppresses arrhythmias in conscious rats with chronic heart failure after myocardial infarction. Conf Proc IEEE Eng Med Biol Soc. 2005;7:7072-5
37. Zhang Y, Popovic ZB, Bibevski S, Fakhry I, Sica DA, Van Wagoner DR, Mazgalev TN.: Chronic vagus nerve stimulation improves autonomic control and attenuates systemic inflammation and heart failure progression in a canine high-rate pacing model. Circ Heart Fail 2009;2:692–699.
38. Sabbah HN, Wang M, Jiang A, Ruble SB, Hamann JJ.: Vagus nerve stimulation improves left ventricular function in dogs with heart failure. J Am Coll Cardiol 2010;55(suppl):A16.E151.
39. Mortara A, La Rovere MT, Pinna GD, Prpa A, Maestri R, Febo O, Pozzoli M, Opasich C, Tavazzi L.: Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. Circulation 1997;96:3450–3458.
40. La Rovere M.T., Bigger J.T., Marcus F.I., Mortara A., Schwartz P.J.: Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) investigators. Lancet. 1998; 351: 478—84.
41. Lechat P., Hulot J.S., Escolano S. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBISII trial. Circulation. 2001; 103: 1428—33.
42. Peter J. Schwartz, Gaetano M. De Ferrari, Antonio Sanzo et al.: Long term vagal stimulation in patients with advanced heart failure. First experience in man. European Journal of Heart Failure Volume 10, Issue 9, pages 884–891, September 2008
43. De Ferrari GM, Crijns HJGM, Borggrefe M, Milasinovic G, Smid J, Zabel M, et al.: Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J 2011; 32:847–55.
44. Dennert R, Crijns HJ, Smid J, et al.: Long-term benefits of vagal nerve stimulation therapy in heart failure. Circulation. 2012; 126:A17001.
45. Rush AJ, Marangell LB, Sackeim HA, et al.: Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry 2005;58:347–54
46. John P. O'Reardon, MD, Pilar Cristancho, MD, and Andrew D. Peshek, MD.: Vagus Nerve Stimulation (VNS) and Treatment of Depression: To the Brainstem and Beyond. Psychiatry (Edgmont). 2006 May; 3(5): 54–63. Published online 2006 May. PMCID: PMC2990624.
47. Е.Н. Павлюкова, М.А. Кузьмичкина, С.А. Афанасьев, Р.С. Карпов: Аурикулярная вагусная стимуляция в лечении больных с левожелудочковой дисфункцией. 2013. Клиническая медицина. № 7. С. 27 - 32.
48. Dicarlo L, Libbus I, Amurthur B, Kenknight BH, Anand IS.: Autonomic regulation therapy for the improvement of left ventricular function and heart failure symptoms: the ANTHEM-HF study. J Card Fail. 2013 Sep;19(9):655-60. doi: 10.1016/j.cardfail.2013.07.002.
49. Premchand RK, Sharma K, Mittal S, Monteiro R, Dixit S, Libbus I, DiCarlo LA, Ardell JL, Rector TS, Amurthur B, KenKnight BH, Anand IS. Extended Follow-Up of Patients with Heart Failure Receiving Autonomic Regulation Therapy in the ANTHEM-HF Study. J Card Fail. 2015 Nov 11.
50. Faiez Zannad, Gaetano M. De Ferrari, Anton E. Tuinenburg, David Wright, Josep Brugada, Christian Butter, Helmut Klein, Craig Stolen, Scott Meyer, Kenneth M. Stein, Agnes Ramuzat, Bernd Schubert, Doug Daum, Petr Neuzil, Cornelis Botman, Maria Angeles Castel, Antonio D’Onofrio, Scott D. Solomon, Nicholas Wold, and Stephen B. Ruble.: Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized controlled trial. European Heart Journal (2015) 36, 425–433, doi:10.1093/eurheartj/ehu345
51. Michael R. Gold, MD, PhD1; Dirk J. Van Veldhuisen, MD, PhD2; Paul J. Hauptman, MD3; Martin Borggrefe, MD4; Spencer H. Kubo, MD5; Randy A. Lieberman, MD6; Goran Milasinovic, MD7; Brett J. Berman, MD8; Sanja Djordjevic, MD9; Suresh Neelagaru, MD10; Peter J. Schwartz, MD11; Randall C. Starling, MDs, MPH12; Douglas L. Mann, MD13.: Vagus Nerve Stimulation for the Treatment of Heart Failure: The INOVATE-HF Trial. J Am Coll Cardiol. 2016;():. doi:10.1016/j.jacc.2016.03.525 (abstr.)
52. Hollinger P, Khatami R, Gugger M, Hess CW, Bassetti CL.: Epilepsy and obstructive sleep apnea. Eur Neurol. 2006;55:74–9.
53. Murray BJ, Matheson JK, Scammell TE.: Effects of vagus nerve stimulation on respiration during sleep. Neurology. 2001;57:1523–4.”
54. Malow BA, Edwards J, Marzec M, Sagher O, Fromes G.: Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology. 2000 Nov 28;55(10):1450-4.
Рецензия
Для цитирования:
Сыровнев В.А., Лебедев Д.С., Михайлов Е.Н. СТИМУЛЯЦИЯ БЛУЖДАЮЩЕГО НЕРВА В КАРДИОЛОГИИ. Трансляционная медицина. 2017;4(2):6-16. https://doi.org/10.18705/2311-4495-2017-4-2-6-16
For citation:
Syrovnev V.A., Lebedev D.S., Mikhaylov E.N. VAGUS NERVE STIMULATION IN CARDIOLOGY. Translational Medicine. 2017;4(2):6-16. (In Russ.) https://doi.org/10.18705/2311-4495-2017-4-2-6-16
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