THE DYNAMICS OF THE LEVEL OF 25-OH-D DURING PREGNANCY WHILE TAKING 500 IU AND 4000 IU KOLEKALTSIFEROL

The reason why the level of vitamin D saturation in pregnant women is very important is because it has a crucial influence on the prevention of pregnancy complications. There is information about great prevalence of vitamin D deficit all around the world. In the article results of randomized prospective controlled research about serum level of 25-hydrocholecalciferol (25-OH-D) of women who had been taking different doses of cholecal-ciferol are shown. The goal of this research is to estimate the impact of different daily doses of cholecalciferol (from 500 ME to 4000 ME) on the serum level of 25-OH-D in pregnant women with initial vitamin D deficit. The research included 68 pregnant women initially from 12 to 14 weeks of pregnancy that had been randomized to 2 groups. The first group (n1=45) consisted of women who had been taking 500 ME of cholecalciferol every day since first trimester to parturition. The second group included women who had been taking 4000 ME (n2=23) of cholecalciferol since the starting of the research to parturition. In the beginning of the research women from both groups had no significant difference in serum level of 25-OH-D: the first group had 16.45 ng/ml and the second group had 16.85 ng/ml. The level of 25-OH-D was checked during 12-14, 24-26 and 34-36 weeks of pregnancy. The first group of women who took daily 500 ME of cholecalciferol hasn’t shown any significant changing of the 25-OH-D serum level. Up to parturition no women of the first group has shown the serum level of 25-OH-D that could meet the standard. Vice versa 82.61% (n-19) of women from the second group met the standard of 25-OH-D level in serum before 26th week of pregnancy and 100% (n-23) of the women met the standard up to 34th week of pregnancy. By 34th week of pregnancy in the first group of women an average level of 25-OH-D in serum was 19.48 ng/ml (±0,70) and in the second group the average level was 44.95 ng/ml (±0,80). The research has shown that taking of 4000 ME of cholecalciferol by women with initial vitamin D deficit is highly efficient to achieve the standard of serum level of 25-OH-D and safe.

витамин D, 25-ОН-О, колекальциферол, беременность, дефицит витамина D, недостаточность витамина D, vitamin D, 25-OH-D, pregnancy, deficiency of vitamin D, insufficiency of vitamin D

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