Objective. Estimation of individual risk transformation of paroxysmal atrial fibrillation (AF) in the permanent form in medication treated ischemic heart disease (IHD) patients.

Design and Methods. Analysis includes 149 IHD patients with paroxysmal AF. Their treatment consisted of drug combination usually used in IHD patients including beta-blockers. No other medications with antiarrhythmic properties were used. Comparisons between the means of the values were made by Student’s test and exact Fisher method. Selection of the factors most informative for risk of the paroxysmal AF transformation in the permanent form was realized with the logistic discriminant analysis.

Results. Within three-years follow-up paroxysmal AF remained in 102 (68%) patients while in 47 (32%) cases it transformed in the permanent form of AF. It is revealed that risk of the paroxysmal AF transformation is associated with increase of aging, dimension of the left atrium, atrial ectopic activity and decrease of the left ventricle ejection fraction.

Conclusion. The offered estimation of the individual paroxysmal AF transformation risk for IHD patients in the permanent form of AF during three-years follow-up period is characterized by high prognostic accuracy: 97% for preservation of paroxysmal AF, and 93% for its transformation in the permanent form.

We introduce the clinical case of a one-stage endovascular treatment of aortoiliac occlusion, the Lerish syndrome. There were no complications during the treatment. The patient is discharged in a satisfactory condition. The technique of performing operation is described in details. Thus, this method is possible to effectively and safely treatment of Lerish’s syndrome and, in contrast to open reconstructive interventions with less trauma.

Purpose. Search of adequacy of parameters of supplying of the blood in warmly vascular system by means of the pump of heartassist device to parameters of a natural circulation on the basis of creation of the sure-flow rate characteristic of the left ventricle of heart according to existing in medical literature experiments.

Materials and methods. Basis for construction pressure-flow rate characteristic of the left ventricle of heart polycardiograms, which are received as a result of the most exact experiment, served. The characteristics of the polycardiogram used for construction consider fluctuations of an expense and pressure after closing of the aortal valve.

Results. The cyclic pressure-flow rate characteristic of the left ventricle of heart in coordinates pressure-flow rate. The area of the received characteristic in the accepted coordinates represents cyclic power of a left ventricle of heart, including power costs of closing of the aortal valve.

Conclusion. The received pressure-flow rate characteristic of the left ventricle of heart allows to specify a metabolic cost on commission of a cordial cycle, to specify laws of the supply and a pressure for pumps, at further static processing of the existing polycardiograms the received characteristic of heart can serve as specification of the existing diagnostic receptions which are carried out on development of parameters of an expense, pressure and also independent diagnostic parameter, can be also used when modeling the blood circulatory system.

Background: Extracranial stereotactic body radiation therapy is non-invasive alternative to other local treatment methods of patients with liver metastases. One of the main criteria for successful planning of the irradiation volume is a clear visualization of the contour of the tumor. MRI provides more valuable information about the boundaries of the tumor and critical structures, which makes its implementation mandatory when collecting anatomical and topographic data for the planning of stereotactic radiotherapy in patients with metastases in the liver. The use of different pulse sequences and the thickness of the slices affects the quality of visualization of the contour of the target, the fusion of CT and MRI data to select the irradiation volume.

Objective: Improving the quality of anatomo-topographic data collection using the MRI for planning stereotactic radiation therapy in patients with liver metastases.

Design and methods: Magnetom Siemens Avanto and Aera RT 1.5T. MRI protocol: overview T2 Cor and T2 Sag 5mm, T1ax VIBE DIXION 1.5mm, T2ax SPACE 2mm, DWI (ADC), T2ax TSE BLADE FS 3mm. With the help of this technique 15 patients with a total of 20 liver metastases was planned and executed stereotactic radiation therapy.

Results: Used slice thickness and pulse sequences provide high spatial resolution, clear visualization of the contour of the tumor, the absence of technical difficulties with the fusion of CT and MRI tomograms at the station planning and the selection of the volume exposure.

Conclusion: Optimization of the MRI protocol to collect anatomo-topographic data allowed to increase their informative value and diagnostic value for planning of SBRT in patients with liver metastases.

The publication provides the latest data on the problem of drug liver disease, particularly during pregnancy. Classification of liver diseases, selected risk factors, mechanisms of drug liver damage and laboratory tests are described. Physiological changes in liver function during pregnancy that must be considered in the diagnosis of drug liver disease in pregnancy are outlined.

Background: Skin cells are capable of the local synthesis of sex and regulatory hormones which makes it an analogue of the hypothalamic-pituitary-gonadal system and facilitates independent melanoma hormonogenesis.

Aims: to study the level of hormones in the tumor, perifocal zone, the skin is unaffected, and the pituitary gland in the dynamics of growth of melanoma B16/F10 in female C57BL/6 mice.

Materials and methods: Changes in the local steroidogenesis in the dynamics of the growth of transplanted В16/F10 melanoma (from week 1 to week 4) were studied in 40 female С57BL/6 mice. Hormones were determined by standard ELISA methods and radioimmunoassay in homogenates of tumor, surrounding tissues and intact tissues.

Results: Tumor and then surrounding tissues showed an increase in estrogens, mostly due to estrone increase, with the development of relative androgen deficiency primarily in tumor and then in the perifocal zone and in intact tissues.

Conclusions: Regulation and stimulation of such changes were performed at early stages by autocrine regulatory mechanisms and cells of primary and growing melanoma, and later by the paracrine method spreading its influence on surrounding tissues and the whole body.