THE CHANGES OF HOMEOSTASIS AND FUNCTION ACTIVITY OF ENDOTHELIUM BY NEWBORNS WITH HYPOXIC DAMAGE OF CENTRAL NERVOUS SYSTEM IN COMBINATION WITH CONGENITAL HEART DEFECTS

Abstract

Hypoxia recognized as the major etiologic factor of perinatal pathology of the nervous system. Changes of central hemodynamics in patients with congenital heart defects affect the cerebral blood flow and cause acute and chronic hypoxic-ischemic brain damage. The aim of the study was to investigate the characteristics of hemostasis and functional activity of endothelium with congenital heart defects in newborns with hypoxic central nervous system. We observed of varying degrees of gestation infants with hypoxic central nervous system and congenital heart disease. In the study of nervous and mental development of infants with hypoxic central nervous system during the first year of life was revealed declines quantify motor, speech and mental functions in all groups of observations. It is noted that in neonates with hypoxic encephalopathy and congenital heart disease, a change of hemostatic function, characterized by hypercoagulability, against endothelial dysfunction.