MYOCARDIAL REMODELING IN PATIENTS WITH ATRIAL FIBRILLATION IN CHRONIC HEART FAILURE
https://doi.org/10.18705/2311-4495-2018-5-2-15-21
Abstract
Background. Dissatisfaction with the results of drug and non-drug therapy of atrial fibrillation causes clinicians and scientists to seek new methods for treatment of this arrhythmia.
Objective. The paper aims at studying the features of cardiac remodeling and morphological changes of myocardium in chronic heart failure patients with atrial fibrillation.
Materials and methods. The features myocardial remodeling and the morphology of the myocardium of a right atrial auricle segment were studied, respectively, by echocardiography and by microscopy in chronic heart failure patients with and without atrial fibrillation.
Results. Compared to patients without cardiac arrhythmia, patients with chronic heart failure, with atrial fibrillation, revealed more pronounced hypertrophy of the walls of the myocardium of the left and right ventricles, increased myocardial mass index, dilatation of both right and left atria, increased pressure in the pulmonary artery and veins. With a constant form, unlike paroxysmal atrial fibrillation, structural disorders of the walls and chambers of the heart were more pronounced. The interstitial edema of the myocardium of the auricle of the right atrium was detected in patients with atrial fibrillation compared to patients without arrhythmias.
Conclusion. More pronounced atrial dilatation in heart failure patients with atrial fibrillation is accompanied by interstitial myocardial edema, which, perhaps, is one of the reasons for the emergence and maintenance of atrial fibrillation.
About the Author
V. V. Kirillova
Institute for medical cell technologies; Ural state medical University
Russian Federation
Russian Federation
Venera V. Kirillova - MD, PhD, senior researcher, Institute for medical cell technologies.
Karla Marksa str., 22 a, Ekaterinburg, 620026
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Review
For citations:
Kirillova V.V. MYOCARDIAL REMODELING IN PATIENTS WITH ATRIAL FIBRILLATION IN CHRONIC HEART FAILURE. Translational Medicine. 2018;5(2):15-21. (In Russ.) https://doi.org/10.18705/2311-4495-2018-5-2-15-21
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