ESTIMATION OF PROGNOSTIC POSSIBILITIES OF PAROXYSMAL ATRIAL FIBRILLATION TRANSFORMATION IN THE PERMANENT FORM IN MEDICATION TREATED ISCHEMIC HEART DISEASE PATIENTS
https://doi.org/10.18705/2311-4495-2017-4-3-5-11
Abstract
Objective. Estimation of individual risk transformation of paroxysmal atrial fibrillation (AF) in the permanent form in medication treated ischemic heart disease (IHD) patients.
Design and Methods. Analysis includes 149 IHD patients with paroxysmal AF. Their treatment consisted of drug combination usually used in IHD patients including beta-blockers. No other medications with antiarrhythmic properties were used. Comparisons between the means of the values were made by Student’s test and exact Fisher method. Selection of the factors most informative for risk of the paroxysmal AF transformation in the permanent form was realized with the logistic discriminant analysis.
Results. Within three-years follow-up paroxysmal AF remained in 102 (68%) patients while in 47 (32%) cases it transformed in the permanent form of AF. It is revealed that risk of the paroxysmal AF transformation is associated with increase of aging, dimension of the left atrium, atrial ectopic activity and decrease of the left ventricle ejection fraction.
Conclusion. The offered estimation of the individual paroxysmal AF transformation risk for IHD patients in the permanent form of AF during three-years follow-up period is characterized by high prognostic accuracy: 97% for preservation of paroxysmal AF, and 93% for its transformation in the permanent form.
About the Authors
S. Yu. Ivanov
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Sergey Yu. Ivanov - PhD, researcher, Research Laboratory for preventive cardiology.
Akkuratova str. 2, Saint Petersburg, 197341
B. B. Bondarenko
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Boris B. Bondarenko - PhD, MD, professor, Head of the Research Laboratory for preventive cardiology.
Saint Petersburg
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For citations:
Ivanov S.Yu., Bondarenko B.B. ESTIMATION OF PROGNOSTIC POSSIBILITIES OF PAROXYSMAL ATRIAL FIBRILLATION TRANSFORMATION IN THE PERMANENT FORM IN MEDICATION TREATED ISCHEMIC HEART DISEASE PATIENTS. Translational Medicine. 2017;4(3):5-11. (In Russ.) https://doi.org/10.18705/2311-4495-2017-4-3-5-11
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