The effect of the TNFα gene rs1800629 polymorphism on cytokine profile parameters in the complicated wound healing in combat trauma victims
https://doi.org/10.18705/2311-4495-2024-11-5-419-427
EDN: DIRGLY
Abstract
Background. In the wound process, there is a high probability of complications in the form paratraumatic eczema (РТЕ), which determines the severity the course of wound repair. Genetic factors responsible for the regulation of cytokines a leading role in the etiopathogenesis of РТЕ. Aim — determine the relationship of TNFa gene rs1800629 with the development of РТЕ and IL-1ß, TNFα, IL-6. Materials and methods. The study included 162 patients after surgical interventions. Group I — 82 people with complications in the form PTE and II — 80 people without complications. The study rs1800629 TNFα gene was carried out by the poly- merase chain reaction method. The levels TNFα, IL-1β and IL-6 in the blood was determined by the enzyme immunoassay method. Results. A connection with PTE was established with of rs1800629 gene TNFα (p = 0.033 and p = 0.005). The genotypes GA (OR = 1.64; CI 0.83–3.24) and AA (OR = 2.94; CI 0.9–9.67), allele A (OR = 2.13; CI 1.26–3.6) rs1800629 influenced the increased chances of developing PTE. In group II the IL- 1β, TNFα, IL-6 indicators were increased (p < 0.001) in carriers of the AA genotype rs1800629. Conclusion. rs1800629 TNFα gene is associated with development of PTE. An increase in the levels IL-1β, TNFα, IL-6 was associated with the presence of a pathogenetic factor — AA genotype rs1800629 TNFα gene in development of complications.
About the Authors
M. S. Kishenya
Donetsk State Medical University named after M. Gorky
Russian Federation
Competing Interests:
Russian Federation
Maria S. Kishenya, MD, PhD, Associate Professor, Senior researcher at the Central Research Laboratory
Ilyich ave., 16, Donetsk, 283003
Competing Interests:
The authors declare no conflict of interest.
D. V. Sobolev
Donetsk State Medical University named after M. Gorky
Russian Federation
Competing Interests:
Russian Federation
Dmitrii V. Sobolev, MD, PhD, Doctor of Medical Sciences, Professor, Professor of the Department of Combustiology and Plastic Surgery of the Faculty of Internship and Postgraduate Education
Donetsk
Competing Interests:
The authors declare no conflict of interest.
E. V. Anchikova
MedVitro Limited Liability Company
Russian Federation
Competing Interests:
Russian Federation
Ekaterina V. Anchikova, dermatovenerologist
Krasnogorsk
Competing Interests:
The authors declare no conflict of interest.
A. V. Visyagin
Donetsk State Medical University named after M. Gorky
Russian Federation
Competing Interests:
Russian Federation
Artur V. Visyagin, Senior laboratory assistant of the Department of Combustiology and Plastic Surgery of the Faculty of Internship and Postgraduate Education
Donetsk
Competing Interests:
The authors declare no conflict of interest.
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For citations:
Kishenya M.S., Sobolev D.V., Anchikova E.V., Visyagin A.V. The effect of the TNFα gene rs1800629 polymorphism on cytokine profile parameters in the complicated wound healing in combat trauma victims. Translational Medicine. 2024;11(5):419-427. (In Russ.) https://doi.org/10.18705/2311-4495-2024-11-5-419-427. EDN: DIRGLY
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