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Influence of diabetes mellitus on the results of providing assistance in critical lower limb ischemia

https://doi.org/10.18705/2311-4495-2025-12-3-204-213

Abstract

Introduction. The elimination of critical ischemia in patients with diabetes mellitus requires a delicate approach due to the high risk of complications. The purpose of this study is to analyze the results of revascularization in patients with critical ischemia associated with type 2 diabetes mellitus. Materials and methods. The study involved 135 patients who underwent reconstructive interventions for peripheral arterial disease. Of these, 48 patients suffered from diabetes mellitus, and in 87 patients no disorders of carbohydrate metabolism were registered. The results of surgical interventions were prospectively assessed during the first 30 days after surgery and retrospectively analyzed. Endpoints: primary — reconstructionrelated complications; secondary — major amputations. Adverse events assessed included bleeding, surgicalsite infection, myocardial infarction, stroke, and thrombosis. Results and discussion. Patients with diabetes are more likely to experience adverse effects (52.1 % vs 40.2 %, respectively). In addition, they have more severe postoperative complications. A major role is played by impaired collateral circulation in patients with diabetes mellitus, as well as the presence of concomitant pathologies. Conclusion. At the stage of critical ischemia, the number of dangerous complications after reconstructive surgery increases in people with diabetes mellitus. Against the background of critical ischemia in diabetes mellitus and without it, it is necessary to choose the best option for reconstructive care, taking into account the Archi index, in order to reduce the invasiveness of surgical intervention.

About the Authors

N. I. Glushkov
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

 Nikolay I. Glushkov, D.M.Sc., Professor, Head of the Department of General Surgery 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



A. N. Zvyagintseva
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Anastasia N. Zvyagintseva, Medical Student, Faculty of Medicine 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



P. D. Puzdryak
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Petr D. Puzdryak, Post-graduate Student, Department of General Surgery 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



A. V. Milkova
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Anna V. Milkova, Medical Student, Faculty of Medicine 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



A. Y. Ponomarenko
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Alina Yu. Ponomarenko, Medical Student, Faculty of Medicine 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



A. A. Volkova
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Arina A. Volkova, Medical Student, Faculty of Medicine 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



K. V. Zhdanovich
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Kristina V. Zhdanovich, Post-graduate Student, Department of General Surgery 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



M. A. Ivanov
North-Western State Medical University named after. I. I. Mechnikov" Ministry of Health of the Russian Federation
Russian Federation

Mikhail A. Ivanov, D.M.Sc., Professor, Department of General Surgery 


Competing Interests:

Авторы заявили об отсутствии потенциального конфликта интересов 



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For citations:


Glushkov N.I., Zvyagintseva A.N., Puzdryak P.D., Milkova A.V., Ponomarenko A.Y., Volkova A.A., Zhdanovich K.V., Ivanov M.A. Influence of diabetes mellitus on the results of providing assistance in critical lower limb ischemia. Translational Medicine. 2025;12(3):204-213. (In Russ.) https://doi.org/10.18705/2311-4495-2025-12-3-204-213

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ISSN 2311-4495 (Print)
ISSN 2410-5155 (Online)