Pecularities of the ischemic heart disease clinical course in patients with different provision of vitamin D, residents of St. Petersburg: an association with a complex of genotypes of vitamin D receptor
O. A. Berkovich,
Zh. I. Ionova,
S. N. Pchelina,
J. Du,
V. V. Miroshnikova,
A. A. Botkina,
K. V. Dracheva,
O. D. Belyaeva https://doi.org/10.18705/2311-4495-2022-9-2-6-14
Abstract
Background. Vitamin D has been shown to reduce the risk of atherosclerosis development. Vitamin D receptors (VDRs) mediate the protective effects of vitamin D on immune inflammation in the vascular wall. Polymorphisms of the VDR gene are involved in the regulation of the stability of its mRNA. The carriage of some polymorphisms may affect the development of atherosclerosis.
Objective. To study the availability of vitamin D in patients with coronary artery disease (CAD) with various VDR polymorphisms.
Design and methods. The vitamin D level in blood serum was determined by enzyme immunoassay. The genotypes of the VDR gene were determined in 302 patients with CAD and in 196 patients without CAD by PCR.
Results. The level of vitamin D in patients with CAD was lower than in controls. The presence of the studied VDR polymorphisms was not associated with an increased risk of CAD. The content of vitamin D was higher in patients with the BB vs. bb genotype of the VDR gene (BsmI), in carriers of the AA vs. aa genotype (ApaI), in carriers of TT vs. tt genotype of the VDR gene (TaqI).
Conclusion. TaqI, FokI, ApaI and BsmI polymorphisms are not associated with the risk of CAD. Vitamin D level in the CAD patients with BB and AA genotype of the VDR gene was higher compare with bb and aa genotypes.
Keywords
atherosclerosis,
coronary artery disease,
immune inflammation,
vitamin D deficiency,
vitamin D receptor,
vitamin D
Supporting agencies: State task No. AAAAA-A18-118070690073-2 “Cardiovascular diseases in obesity: molecular genetic predictors of development, progressed and treatment approaches”.
About the Authors
O. A. Berkovich
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga A. Berkovich, PhD, professor of the Faculty Therapy Department with a course of endocrinology and cardiology with a clinic, head of Ischemic Heart Disease Laboratory of Research Institute of Cardiovascular Diseases of Scientific and Clinical Research Center
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
Zh. I. Ionova
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Zhanna I. Ionova, assistant of the Faculty Therapy Department with a course of endocrinology and cardiology with a clinic
L’va Tolstogo str., 6/8, Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
S. N. Pchelina
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Sofya N. Pchelina, PhD, head of Department of Molecular Genetic and Nanobiological Technologies of Scientific and Clinical Research Center
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
J. Du
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Jin Du, PhD student at the Department of Faculty Therapy with a course in Endocrinology and Cardiology with a clinic
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
V. V. Miroshnikova
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Valentina V. Miroshnikova, PhD, head of the Laboratory of Medical Genetics of the Department of Molecular Genetic and Nanobiological Technologies of Scientific and Clinical Research Center
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
A. A. Botkina
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Arina A. Botkina, student
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
K. V. Dracheva
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Kseniya V. Dracheva, laboratory assistant of the Laboratory of Medical Genetics of the Department of Molecular Genetic and Nanobiological Technologies of Scientific and Clinical Research Center
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
O. D. Belyaeva
Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Olga D. Belyaeva, PhD, professor of the Faculty Therapy Department with a course of endocrinology and cardiology with a clinic, head of Arterial Hypertension Laboratory of Research Institute of Cardiovascular Diseases of Scientific and Clinical Research Center
Saint Petersburg
Competing Interests:
The authors declare no conflict of interest.
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For citations:
Berkovich O.A., Ionova Zh.I., Pchelina S.N., Du J., Miroshnikova V.V., Botkina A.A., Dracheva K.V., Belyaeva O.D. Pecularities of the ischemic heart disease clinical course in patients with different provision of vitamin D, residents of St. Petersburg: an association with a complex of genotypes of vitamin D receptor. Translational Medicine. 2022;9(2):6-14. (In Russ.) https://doi.org/10.18705/2311-4495-2022-9-2-6-14
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