Vegetotropic and emotional-behavioral effects of moxonidine in normotensive rats
https://doi.org/10.18705/2311-4495-2020-7-2-65-72
Abstract
The purpose of this work was to study the vegetotropic and emotional-behavioral effects of the imidazoline receptor agonist moxonidine. Materials and methods. In awake males of the Wistar line, the effect of moxonidine in various doses (without and with the preliminary introduction of the predominant blocker of the imidazoline receptors of efaroxan) on hemodynamic parameters, heart rate variability (HRV), cardiovascular response to stress and on the behavior in the “open field” test was studied. Results. It was shown that moxonidine in the studied doses does not significantly affect the hemodynamic parameters, the components of the HRV spectrum and the locomotor activity of animals, however, it reduces the tachycardic response to the call. The last effect of moxonidine is removed by the preliminary administration of efaroxane. Conclusion. Based on the results of the study and literature data, it can be assumed that different types of receptors are involved in reducing the cardiovascular response to stress and in the sedative effect of drugs of the imidazoline group. In the first case, the effect is due to the activation of I1 receptors, in the second — α2-adrenergic receptors. Also, the results of the experiments allow us to conclude that in normotensive rats, the functional activity of imidazoline receptors is reduced in comparison with hypertensive rats. Perhaps this circumstance explains the low efficacy of moxonidine in Wistar rats.
About the Authors
V. A. Tsyrlin
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Tsyrlin Vitaliy A., MD, Senior Researcher, Laboratory of Experimental Physiology and Pharmacology
Saint Petersburg
M. G. Pliss
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Pliss Mikhail G., PhD, Head of the Laboratory of Experimental Physiology and Pharmacology, Almazov National Medical Research Centre; Head of the Laboratory of Biophysics of Blood Circulation, Academician I. P. Pavlov First Saint Petersburg State Medical University
Saint Petersburg
N. V. Kuzmenko
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Kuzmenko Natalia V., PhD, Senior Researcher, Laboratory of Experimental Physiology, Almazov National Medical Research Centre; Laboratory of Biophysics of Blood Circulation, Academician I. P. Pavlov First Saint Petersburg State Medical University
Parkhomenko str. 15-B, Saint Petersburg, 194156
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Review
For citations:
Tsyrlin V.A., Pliss M.G., Kuzmenko N.V. Vegetotropic and emotional-behavioral effects of moxonidine in normotensive rats. Translational Medicine. 2020;7(2):65-72. (In Russ.) https://doi.org/10.18705/2311-4495-2020-7-2-65-72
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