Synthesis of colloidal silver nanoparticles and their stabilization in several ways for external applications
https://doi.org/10.18705/2311-4495-2020-7-2-42-51
Abstract
Background. Today, many studies reflect an increase in the antibacterial effect of drugs through the use of a colloidal solution of silver nanoparticles. Creation of the various forms of drugs for an external use with a slow-release active component and antibacterial activity is relevant and promising for use in the treatment of superficial wounds and injuries. Objective. Synthesis and stabilization of quasispherical silver nanoparticles for external applications. Design and methods. The citrate method was used for the synthesis of colloidal silver. Dosage forms of external use were prepared by several methods: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Results. Several methods of possible preparation of finished dosage forms based on colloidal silver nanoparticles have been demonstrated: reaction with albumin, liposomal form, thickening with Aerosil and incorporation into microspheres. Conclusion. Further investigation of both antimicrobial activity and cytotoxicity will reveal dosage forms with optimal efficiency/safety ratio.
About the Authors
D. V. Korolev
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Korolev Dmitry V., PhD, Head of the Research Laboratory of Nanotechnologies, Almazov National Medical Research Centre; Junior Researcher of the Academician I. P. Pavlov First Saint Petersburg State Medical University
Saint Petersburg
M. V. Shumilo
Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Shumilo Mikhail V., Student
Saint Petersburg
M. S Istomina
Almazov National Medical Research Centre; Saint Petersburg Electrotechnical University “LETI”
Russian Federation
Russian Federation
Istomina Maria S., PhD Student of Saint Petersburg Electrotechnical University “LETI”; Junior Research Assistant of the Research Laboratory of Nanotechnologies, Almazov National Medical Research Centre
Saint Petersburg
G. A. Shulmejster
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Shulmejster Galina A., Junior Research Assistant of the Research Laboratory of Nanotechnologies
Saint Petersburg
A. N. Gorshkov
Smorodintsev Research Institute of Influenza
Russian Federation
Russian Federation
Gorshkov Andrey N., PhD, Head of the Laboratory of Intracellular Signaling and Transport
Saint Petersburg
A. N. Krutikov
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Krutikov Aleksandr N., PhD, Leading Researcher of the Research Department of Infiltrative Heart Diseases of Almazov National Medical Research Centre
Saint Petersburg
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Review
For citations:
Korolev D.V., Shumilo M.V., Istomina M.S., Shulmejster G.A., Gorshkov A.N., Krutikov A.N. Synthesis of colloidal silver nanoparticles and their stabilization in several ways for external applications. Translational Medicine. 2020;7(2):42-51. (In Russ.) https://doi.org/10.18705/2311-4495-2020-7-2-42-51
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