Preview

Трансляционная медицина

Расширенный поиск

Висфатин и его роль в регуляции репродуктивной системы

https://doi.org/10.18705/2311-4495-2019-6-2-25-36

Полный текст:

Аннотация

Висфатин, называемый также колониестимулирующим фактором прекурсоров B-клеток, вырабатывается преимущественно висцеральным жиром, и в клетках-мишенях активирует 3-фосфоинозитидный путь, каскад митогенактивируемых протеинкиназ и ряд других эффекторных систем. В последние годы появились данные о том, что висфатин регулирует функциональную активность гипоталамо-гипофизарно-гонадной оси, контролируя синтез и секрецию гонадолиберина гипоталамическими нейронами и гонадотропинов гонадотрофами гипофиза, а также влияет на процессы стероидогенеза и фолликулогенеза, воздействуя на репродуктивные ткани. Одним из механизмов его стероидогенного действия является потенцирование стимулирующего влияния инсулиноподобного фактора роста-1 на синтез половых стероидных гормонов. Поскольку продукция висфатина и активность его сигнальной системы в значительной степени меняются в условиях сахарного диабета и метаболического синдрома, то это самым непосредственным образом влияет на регуляцию им репродуктивных функций. Висфатин играет важную роль в сохранении функциональной активности яичников и в поддержании нормального качества ооцитов при старении. Обзор посвящен проблеме структурно-функциональной организации висфатина и его сигнальной системы, роли висфатина в регуляции женской и мужской репродуктивных систем, механизмам его действия на гипоталамо-гипофизарно-гонадную ось.

Об авторе

А. О. Шпаков
Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии им. И.М. Сеченова» Российской академии наук
Россия

Шпаков Александр Олегович - доктор биологических наук, заведующий лабораторией молекулярной эндокринологии и нейрохимии.

Пр. Тореза, д. 44, Санкт-Петербург, 194223



Список литературы

1. Roumaud P, Martin LJ. Roles of Leptin, Adiponectin and Resistin in the Transcriptional Regulation of Steroidogenic Genes Contributing to Decreased Leydig Cells Function in Obesity. Horm Mol Biol Clin Investig. 2015;24(1):25-45.

2. Shpakov AO Ryzhov JuR, Bakhtyukov AA et al. The Regulation of the Male Hypothalamic-Pituitary-Gonadal Axis and Testosterone Production by Adipokines (Chapter 2). Advances in Testosterone Action (Ed. by M. Estrada). Intech Open Access Publisher, Rijeka, Croatia. 2018;25-57.

3. Fukuhara A, Matsuda M, Nishizawa M et al. Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin. Science. 2005;307(5708):426-430.

4. Chang YH, Chang DM, Lin KC et al. Visfatin in Overweight/Obesity, Type 2 Diabetes Mellitus, Insulin Resistance, Metabolic Syndrome and Cardiovascular Diseases: A Meta-Analysis and Systemic Review. Diabetes Metab Res Rev. 2011;27(6):515-527.

5. Dahl TB, Holm S, Aukrust P et al. Visfatin/NAMPT: A Multifaceted Molecule with Diverse Roles in Physiology and Pathophysiology. Ann Rev Nutr. 2012;32:229-243.

6. Ognjanovic S, Bao S, Yamamoto SY et al. Genomic Organization of the Gene Coding for Human Pre-B-Cell Colony Enhancing Factor and Expression in Human Fetal Membranes. J Mol Endocrinol. 2001;26(2):107-117.

7. Bae SK, Kim SR, Kim JG et al. Hypoxic Induction of Human Visfatin Gene Is Directly Mediated by Hypoxia-Inducible Factor-1. FEBS Lett. 2006;580(17):4105-4113.

8. Sun Z, Lei H, Zhang Z. Pre-B Cell Colony Enhancing Factor (PBEF), A Cytokine with Multiple Physiological Functions. Cytokine Growth Factor Rev. 20l3;24(5):433-442.

9. Kralisch S, Klein J, Lossner U et al. Hormonal Regulation of the Novel Adipocytokine Visfatin in 3T3-L1 Adipocytes. J Endocrinol. 2005;185(3):R1-R8.

10. MacLaren R, Cui W, Cianflone K. Visfatin Expression is Hormonally Regulated by Metabolic and Sex Hormones in 3T3-L1 Pre-Adipocytes and Adipocytes. Diabetes Obes Metab. 2007;9(4):490-497.

11. Segawa K, Fukuhara A, Hosogai N et al. Visfatin in Adipocytes Is Upregulated by Hypoxia Through HIF1alpha-Dependent Mechanism. Biochem Biophys Res Commun. 2006;349(3):875-882.

12. Dahl TB, Yndestad A, Skjelland M et al. Increased Expression of Visfatin in Macrophages of Human Unstable Carotid and Coronary Atherosclerosis: Possible Role in Inflammation and Plaque Destabilization. Circulation. 2007;115(8):972-980.

13. Hector J, Schwarzloh B, Goehring J et al. TNF-Alpha Alters Visfatin and Adiponectin Levels in Human Fat. Horm Metab Res. 2007;39(4):250-255.

14. Chu CH, Lee JK, Wang MC et al. Change of Visfatin, C-Reactive Protein Concentrations, and Insulin Sensitivity in Patients with Hyperthyroidism. Metabolism. 2008;57(10):1380-1383.

15. Adeghate E. Visfatin: Structure, Function and Relation to Diabetes Mellitus and Other Dysfunctions. Curr Med Chem. 2008;15(18):1851-1862.

16. Stastny J, Bienertova-Vasku J, Vasku A. Visfatin and Its Role in Obesity Development. Diabetes Metab Syndr. 2012;6(2):120-124.

17. Takahashi R, Nakamura S, Yoshida T et al. Crystallization of Human Nicotinamide Phosphoribosyltransferase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63(Pt 5):375-377.

18. Marietta AS, Massarotti A, Orsomando G et al. Crystal Structure of Human Nicotinic acid Phosphoribosyltransferase. FEBS Open Bio. 2015;5:419-428.

19. Wang T, Zhang X, Bheda P et al. Structure of Nampt/ PBEF/Visfatin, A Mammalian NAD+ Biosynthetic Enzyme. Nat Struct Mol Biol. 2006;13(7):661-662.

20. Kang GB, Bae MH, Kim MK et al. Crystal Structure of Rattus Norvegicus Visfatin/PBEF/Nampt in Complex with an FK866-Based Inhibitor. Mol Cells. 2009;27(6):667-671.

21. Revollo JR, Korner A, Mills KF et al. Nampt/ PBEF/Visfatin Regulates Insulin Secretion in Beta Cells As a Systemic NAD Biosynthetic Enzyme. Cell Metab. 2007;6(5):363-375.

22. Kitani T, Okuno S, Fujisawa H. Growth Phase-Dependent Changes in the Subcellular Localization of Pre-B-Cell Colony-Enhancing Factor. FEBS Lett. 2003;544(1-3):74-78.

23. Tanaka M, Nozaki M, Fukuhara A et al. Visfatin Is Released from 3T3-L1 Adipocytes via a Non-Classical Pathway. Biochem Biophys Res Commun. 2007;359(2):194-201.

24. Kim SR, Bae SK, Choi KS et al. Visfatin Promotes Angiogenesis by Activation of Extracellular Signal-Regulated Kinase 1/2. Biochem Biophys Res Commun. 2007;357(1):150-156.

25. Xie H, Tang SY, Luo XH et al. Insulin-Like Effects of Visfatin on Human Osteoblasts. Calcif Tissue Int. 2007;80(3):201-210.

26. Hug C, Lodish HF. Visfatin: A New Adipokine. Science. 2005;307(5708):366-367.

27. Song HK, Lee MH, Kim BK et al. Visfatin: A New Player in Mesangial Cell Physiology and Diabetic Nephropathy. Am J Physiol Renal Physiol. 2008;295(5):F1485-F1494.

28. Adya R, Tan BK, Punn A et al. Visfatin Induces Human Endothelial VEGF and MMP-2/9 Production via MAPK and PI3K/Akt Signalling Pathways: Novel Insights into Visfatin-Induced Angiogenesis. Cardiovasc Res. 2008;78(2):356-365.

29. Kim SR, Bae YH, Bae SK et al. Visfatin Enhances ICAM-1 and VCAM-1 Expression through ROS-Dependent NF-kappaB Activation in Endothelial Cells. Biochim Biophys Acta. 2008;1783(5):886-895.

30. Li Y, Zhang Y, Dorweiler B et al. Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism. J Biol Chem. 2008;283(50):34833-34843.

31. Jia sH, Li Y, Parodo J et al. Pre-B Cell Colony-Enhancing Factor Inhibits Neutrophil Apoptosis in Experimental Inflammation and Clinical Sepsis. J Clin Invest. 2004;113(9):1318-1327.

32. Ye SQ, Simon BA, Maloney JP et al. Pre-B-Cell Colony-Enhancing Factor As a Potential Novel Biomarker in Acute Lung Injury. Am J Respir Crit Care Med. 2005;171(4):361-370.

33. Gosset M, Berenbaum F, Salvat C et al. Crucial Role of Visfatin/Pre-B Cell Colony-Enhancing Factor in Matrix Degradation and Prostaglandin E2 Synthesis in Chondrocytes: Possible Influence on Osteoarthritis. Arthritis Rheum. 2008;58(5):1399-1409.

34. Zhong M, Tan HW, Gong HP et al. Increased Serum Visfatin in Patients with Metabolic Syndrome and Carotid Atherosclerosis. Clin Endocrinol (Oxf). 2008;69(6):878-884.

35. Косыгина А. В., Васюкова О. В. Новое в патогенезе ожирения: адипоки-ны - гормоны жировой ткани. Проблемы эндокринологии. 2009;55(1):44-50.

36. Косыгина А. В., Сосунов В. В., Петеркова В. А. и др. Экспрессия гена адипонектина (ADIPOQ) в подкожной и висцеральной жировой ткани и уровень адипонектина в сыворотке крови у детей. Проблемы эндокринологии. 2010;56(6):3-8.

37. Dupont J, Pollet-Villard X, Reverchon M et al. Adipokines in Human Reproduction. Horm Mol Biol Clin Investig. 2015;24(1):11-24.

38. Shpakov AO, Derkach KV, Berstein LM. Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases. Future Sci OA. 2015;1(3):FSO25.

39. Сорокоумов В. Н., Шпаков А. О. Протеин-фосфотирозинфосфатаза 1B: структура, функции, роль в развитии метаболических расстройств и их коррекция с помощью ингибиторов фермента. Журнал эволюционной биохимии и физиологии. 2017;53(4):230-240.

40. Romanova IV, Derkach KV, Mikhrina AL et al. The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents. Neurochem Res. 2018;43(4):821-837.

41. Derkach K, Zakharova I, Zorina I et al. The Evidence of Metabolic-Improving Effect of Metformin in Ay/a Mice with Genetically-Induced Melanocortin Obesity and the Contribution of Hypothalamic Mechanisms to This Effect. PLoS One. 2019;14(3):e0213779.

42. Shen CJ, Tsai Em, Lee JN et al. The Concentrations of Visfatin in the Follicular Fluids of Women Undergoing Controlled Ovarian Stimulation are Correlated to the Number of Oocytes Retrieved. Fertil Steril. 2010;93(6):1844-1850.

43. Choi KH, Joo BS, Sun ST et al. Administration of Visfatin During Superovulation Improves Developmental Competency of Oocytes and Fertility Potential in Aged Female Mice. Fertil Steril. 2012;97(5):1234-1241.

44. Reverchon M, Maillard V, Froment P et al. Adiponectin and Resistin: A Role in the Reproductive Functions? Med Sci (Paris). 2013;29(4):417-424.

45. Reverchon M, Rame C, Bertoldo M et al. Adipokines and the Female Reproductive Tract. Int J Endocrinol. 2014;2014:232454.

46. Diot M, Reverchon M, Rame C et al. Expression and Effect of NAMPT (Visfatin) on Progesterone Secretion in Hen Granulosa Cells. Reproduction. 2015;150(1):53-63.

47. Reverchon M, Rame C, Bunel A et al. VISFATIN (NAMPT) Improves In Vitro IGFl-Induced Steroidogenesis and IGF1 Receptor Signaling Through SIRT1 in Bovine Granulosa Cells. Biol Reprod. 2016;94(3):54.

48. Maillard V, Elis S, Desmarchais A et al. Visfatin and Resistin in Gonadotroph Cells: Expression, Regulation of LH Secretion and Signalling Pathways. Reprod Fertil Dev. 2017;29(12):2479-2495.

49. Ocon-Grove OM, Krzysik-Walker SM, Maddineni SR et al. NAMPT (Visfatin) in the Chicken Testis: Influence of Sexual Maturation on Cellular Localization, Plasma Levels and Gene and Protein Expression. Reproduction. 2010;139(1):217-226.

50. Thomas S, Kratzsch D, Schaab M et al. Seminal Plasma Adipokine Levels Are Correlated with Functional Characteristics of Spermatozoa. Fertil Steril. 2013;99(5):1256-1263.

51. Gurusubramanian G, Roy VK. Expression of Visfatin in Alloxan-Induced Diabetic Rat Testis. Acta Histochem. 2014;116(8):1462-1468.

52. Riammer S, Garten A, Schaab M et al. Nicotinamide Phosphoribosyltransferase Production in Human Spermatozoa Is Influenced by Maturation Stage. Andrology. 2016;4(6):1045-1053.

53. Mellouk N, Rame C, Barbe A et al. Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases. Int J Endocrinol. 2018;2018:4579734.

54. Brunetti L, Recinella L, Di Nisio C et al. Effects of Visfatin/PBEF/NAMPT on Feeding Behaviour and Hypothalamic Neuromodulators in the Rat. J Biol Regul Homeost Agents. 2012;26(2):295-302.

55. Cline M, Nandar W, Prall BC et al. Central Visfatin Causes Orexigenic Effects in Chicks. Behav Brain Res. 2008;186(2):293-297.

56. Li Z, Liu X, Zhang P et al. Comparative Transcriptome Analysis of Hypothalamus-Regulated Feed Intake Induced by Exogenous Visfatin in Chicks. BMC Genomics. 2018;19(1):249.

57. Kim DS, Kang S, Moon NR et al. Central Visfatin Potentiates Glucose-Stimulated Insulin Secretion and P-Cell Mass Without Increasing Serum Visfatin Levels in Diabetic Rats. Cytokine. 2014;6 (2):159-166.

58. Hameed W, Yousaf I, Latif R et al. Effect of Visfatin on Testicular Steroidogenesis in Purified Leydig Cells. J Ayub Med Coll Abbottabad. 2012;24(3-4):62-64.

59. Varma V, Yao-Borengasser A, Rasouli N et al. Human Visfatin Expression: Relationship to Insulin Sensitivity, Intramyocellular Lipids, and Inflammation. J Clin Endocrinol Metab. 2007;92(2):666-672.

60. Al-Suhaimi EA, Shehzad A. Leptin, Resistin and Visfatin: The Missing Link Between Endocrine Metabolic Disorders and Immunity. Eur J Med Res. 2013;18:12.

61. Wu MH, Tsai cH, Huang YL et al. Visfatin Promotes IL-6 and TNF-a Production in Human Synovial Fibroblasts by Repressing miR-199a-5p Through ERK, p38 and JNK Signaling Pathways. Int J Mol Sci. 2018;19(1). pii:E190.


Для цитирования:


Шпаков А.О. Висфатин и его роль в регуляции репродуктивной системы. Трансляционная медицина. 2019;6(2):25-36. https://doi.org/10.18705/2311-4495-2019-6-2-25-36

For citation:


Shpakov A.O. Visfatin and Its Role in the Regulation of the Reproductive System. Translational Medicine. 2019;6(2):25-36. (In Russ.) https://doi.org/10.18705/2311-4495-2019-6-2-25-36

Просмотров: 37


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2311-4495 (Print)
ISSN 2410-5155 (Online)