DECREASE IN ACTIVITY OF THE INFLAMMATORY PROCESS AFTER IMPLANTATION OF SILICONE WITH ADSORBED MULTIPOTENT STROMAL CELLS

Background. The wide spread of cellular technologies will sooner or later lead inevitably to the introduction of MMSC or their exosomes to patients who have implanted artificial materials in their organism. The engraftment of foreign bodies is accompanied first by acute and then chronic inflammation, very often acquiring a granulomatous character. A decrease in the activity of the inflammatory response can theoretically improve the results of implantation.
Objective. To study the results of the influence of autologous MMSC of bone marrow origin (AMMSCBMO) adsorbed on silicone, on the inflammatory process that accompanies the implantation of this polymer in theexperiment. Design and methods. In different times, the condition of tissues around the implanted silicone with adsorbed AMMSCBMO was studied by method of light microscopy.

Results. After the implantation of silicone with adsorbed AMMSCBMO, as compared with the results of the introduction of this material without use of cellular technologies, a smaller volume of  loose fibrous connective tissue is formed around the encapsulated polymer. In this connective tissue after AMMSCBMO use the absolute number of all cells is lower in 2 weeks, and the percentage and numerical density of neutrophils — within 1–2 weeks. On the contrary, the relative number of erythrocytes within 1–2 weeks and macrophages at 1–3 weeks under the conditions of AMMSCBMO use were greater.
Conclusion. A smaller volume of loose fibrous connective tissue and a decrease in the severity of cellular infiltration, in particular, the number of neutrophils, around the implanted silicone with  AMMSCBMO indicates a decrease in the activity of the inflammatory reaction as a result of the use of cellular technologies, more rapid cleansing of postoperative wound from debris, the success of reparative processes and the creation of conditions for the integration of a foreign bodies into the organism.

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