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Методы подбора in vitro химиопрепаратов для индивидуальной химиотерапии злокачественных новообразований пациентов

https://doi.org/10.18705/2311-4495-2018-5-3-45-65

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Аннотация

В обзоре рассматриваются методы подбора химио- и биопрепаратов, их комбинаций с использованием 2D и 3D моделей культур клеток для прогнозирования персонифицированного ответа пациентов со злокачественными новообразованиями (рак яичников, желудка, кишечника, легкого, молочной, поджелудочной желез, опухоли головы и шеи) на химиотерапию. Приводятся показатели эффективности (чувствительность, специфичность, пролонгирование общей и безрецидивной выживаемости) методов оценки химиочувствительности на культурах опухолевых клеток при сравнении их с эффективностью химиотерапии пациентов. В статье освещаются преимущества и недостатки описываемых методов и перспективы их дальнейшего применения в клинической практике.

Об авторах

А. Н. Чернов
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия

Чернов Александр Николаевич - научный сотрудник отдела микробиологии, клеточных технологий и молекулярной биологии Центра доклинических и трансляционный исследований Института экспериментальной медицины.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341



Е. П. Баранцевич
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия

Баранцевич Елена Петровна - доктор медицинских наук, заведующая НИО микробиологии.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341



В. Н. Калюнов
ГНУ Институт физиологии НАН Беларуси
Беларусь

Калюнов Владимир Николаевич – доктор биологических наук, профессор, главный научный сотрудник лаборатории нейрофизиологии.

Минск



М. М. Галагудза
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России
Россия

Галагудза Михаил Михайлович - доктор медицинских наук, член-корреспондент РАН, директор Института экспериментальной медицины.

Ул. Аккуратова, д. 2, Санкт-Петербург, 197341



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Для цитирования:


Чернов А.Н., Баранцевич Е.П., Калюнов В.Н., Галагудза М.М. Методы подбора in vitro химиопрепаратов для индивидуальной химиотерапии злокачественных новообразований пациентов. Трансляционная медицина. 2018;5(3):45-65. https://doi.org/10.18705/2311-4495-2018-5-3-45-65

For citation:


Chernov A.N., Barantsevich E.P., Kalunov V.N., Galagudza M.M. The methods of in vitro selection of chemotherapeutic druds for individual chemotherapy of maligant tumors in patinets. Translational Medicine. 2018;5(3):45-65. (In Russ.) https://doi.org/10.18705/2311-4495-2018-5-3-45-65

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ISSN 2311-4495 (Print)
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