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АДИПОНЕКТИН, КАК ЭНДОГЕННЫЙ РЕГУЛЯТОР ГИПОТАЛАМО-ГИПОФИЗАРНО-ГОНАДНОЙ ОСИ

https://doi.org/10.18705/2311-4495-2018-5-5-26-36

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Аннотация

Адипонектин — важнейший адипокин, контролирующий пищевое поведение и энергетический гомеостаз. В настоящее время получено много данных в пользу того, что адипонектин также регулирует функции репродуктивной системы, причем его мишенями являются гипоталамические нейроны, ответственные за синтез и секрецию гонадолиберина, гонадотрофы гипофиза, продуцирующие лютеинизирующий гормон, и гонады. В тканях-мишенях, являющихся звеньями гипоталамо-гипофизарно-гонадной оси, обнаружены все основные компоненты сигнальной системы, регулируемой адипонектином, включая сам адипонектин и оба типа адипонектиновых рецепторов. Нарушения в адипонектиновых сигнальных путях приводят к развитию репродуктивных дисфункций, вследствие чего эти пути в будущем могут стать одной из важнейших мишеней для терапии заболеваний мужской и женской репродуктивных систем. В обзоре рассмотрено современное состояние проблемы участия адипонектина в функционировании гипоталамо-гипофизарно-гонадной оси и взаимосвязи между функциональным статусом репродуктивной системы и активностью адипонектиновой системы в гипоталамических нейронах, гонадотрофах и гонадах.

Об авторах

Ю. Р. Рыжов
1 Федеральное государственное бюджетное учреждение науки Институт эволюционной физиологии и биохимии им. И. М. Сеченова Российской академии наук, Санкт-Петербург 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Министерства здравоохранения Российской Федерации, Санкт-Петербург
Россия
студент 6 курса лечебного факультета


А. О. Шпаков
Федеральное государственное бюджетное учреждение науки Институт эволюционной физиологии и биохимии им. И. М. Сеченова Российской академии наук, Санкт-Петербург
Россия

д.б.н., заведующий лабораторией молекулярной эндокринологии и нейрохимии



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Для цитирования:


Рыжов Ю.Р., Шпаков А.О. АДИПОНЕКТИН, КАК ЭНДОГЕННЫЙ РЕГУЛЯТОР ГИПОТАЛАМО-ГИПОФИЗАРНО-ГОНАДНОЙ ОСИ. Трансляционная медицина. 2018;5(5):26-36. https://doi.org/10.18705/2311-4495-2018-5-5-26-36

For citation:


Ryzhov J.R., Shpakov A.O. ADIPONECTIN AS AN ENDOGENOUS REGULATOR OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS. Translational Medicine. 2018;5(5):26-36. (In Russ.) https://doi.org/10.18705/2311-4495-2018-5-5-26-36

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ISSN 2311-4495 (Print)
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