transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2018-5-5-26-36transmed-418Research ArticleЭНДОКРИНОЛОГИЧЕСКИЕ ЗАБОЛЕВАНИЯMETABOLIC DISEASESАДИПОНЕКТИН, КАК ЭНДОГЕННЫЙ РЕГУЛЯТОР ГИПОТАЛАМО-ГИПОФИЗАРНО-ГОНАДНОЙ ОСИADIPONECTIN AS AN ENDOGENOUS REGULATOR OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXISРыжовЮ. Р.RyzhovJ. R.

студент 6 курса лечебного факультета

student

julian.ryzhov@gmail.comhttps://orcid.org/0000-0002-4293-3162ШпаковА. О.ShpakovA. O.

д.б.н., заведующий лабораторией молекулярной эндокринологии и нейрохимии

MD, PhD, Head of Laboratory of Molecular Endocrinology and Neurochemistry

alex_shpakov@list.ru1 Федеральное государственное бюджетное учреждение науки Институт эволюционной физиологии и биохимии им. И. М. Сеченова Российской академии наук, Санкт-Петербург 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова» Министерства здравоохранения Российской Федерации, Санкт-ПетербургРоссия1.I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg 2 Academician I.P. Pavlov First Saint Petersburg State Medical University, Saint PetersburgRussian FederationФедеральное государственное бюджетное учреждение науки Институт эволюционной физиологии и биохимии им. И. М. Сеченова Российской академии наук, Санкт-ПетербургРоссияI. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint PetersburgRussian Federation201803122018552636Copyright © Рыжов Ю.Р., Шпаков А.О., 20182018Рыжов Ю.Р., Шпаков А.О.Ryzhov J.R., Shpakov A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/418

Адипонектин — важнейший адипокин, контролирующий пищевое поведение и энергетический гомеостаз. В настоящее время получено много данных в пользу того, что адипонектин также регулирует функции репродуктивной системы, причем его мишенями являются гипоталамические нейроны, ответственные за синтез и секрецию гонадолиберина, гонадотрофы гипофиза, продуцирующие лютеинизирующий гормон, и гонады. В тканях-мишенях, являющихся звеньями гипоталамо-гипофизарно-гонадной оси, обнаружены все основные компоненты сигнальной системы, регулируемой адипонектином, включая сам адипонектин и оба типа адипонектиновых рецепторов. Нарушения в адипонектиновых сигнальных путях приводят к развитию репродуктивных дисфункций, вследствие чего эти пути в будущем могут стать одной из важнейших мишеней для терапии заболеваний мужской и женской репродуктивных систем. В обзоре рассмотрено современное состояние проблемы участия адипонектина в функционировании гипоталамо-гипофизарно-гонадной оси и взаимосвязи между функциональным статусом репродуктивной системы и активностью адипонектиновой системы в гипоталамических нейронах, гонадотрофах и гонадах.

Adiponectin is the most important adipokine controlling the food behavior and energy homeostasis. At present, there is much evidence that adiponectin also regulates the functions of the reproductive system, and its targets are hypothalamic neurons responsible for the synthesis and secretion of gonadoliberin, the pituitary gonadotrophs producing the luteinizing hormone, and the gonads. In the target tissues, which are blocks of the hypothalamic-pituitary-gonadal axis, all the main components of adiponectin-regulated signaling system, including adiponectin and both types of adiponectin receptors, are detected. The impairments in the adiponectin signaling pathways lead to the development of reproductive dysfunctions, as a result of which this pathways in the future can become one of the most important targets of therapy of diseases of the male and female reproductive systems. In the review, the current state of the problem of the participation of adiponectin in the functioning of the hypothalamic-pituitary-gonadal axis, and the relationship between the functional status of the reproductive system and the activity of the adiponectin system in hypothalamic neurons, gonadotrophs and gonads are considered.

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The authors declare that there are no conflicts of interest present.