IS RS122537 POLYMORPHISM OF TCF7L2 GENE A COMMON MARKER FOR METABOLIC SYNDROME OR ONLY FOR ITS COMPONENTS?

Objective. We aimed to estimate allele frequency and association of the genetic marker TCF7L2 gene (T-risk allele of rs1225537 SNP of TCF7L2 gene) with hyperglycemia, lipids and abdominal obesity in Saint-Petersburg residents. Materials and Methods. As a part of all-Russian epidemiology survey ESSE-RF, random sampling of 1600 Saint-Petersburg inhabitants stratified by age and sex was involved. All subjects signed informed consent and filled in questionnaire regarding lifestyle risk factors. Anthropometry (weight, height with body mass index (BMI) calculation, waist circumference), blood pressure (BP) and heart rate measurement and fasting blood-tests (lipids, glucose (Abbott Architect 8000, Roche Diagnostics) were performed. Genomic DNA was extracted from blood samples using magnetic bead technology. The TCF7L2 polymorphism rs1225537 was determined using real time PCR method by allele-specific probes (Applied Biosystems). Results: Female carriers of T allele (TT + GT genotypes) had tendency to have higher cholesterol level (5,6 ± 1,3 mmol/l; 5,4 ± 1,3 mmol/l; p = 0,04) compared to females with GG genotype. Among females carriers of T allele only hyperglycemia was observed more frequently compared with female carriers of G allele. The frequency of T- risk allele was 22,6 %. Conclusions: The TCF7L2 genetic variant rs1225537 is associated only with hyperglycemia in Saint-Petersburg residents. The frequency of T allele in Saint-Petersburg residents is the same as in general population (20 %).

метаболический синдром и его компоненты, сердечно-сосудистые заболевания, rs1225537 полиморфизм гена TCF7L2, metabolic syndrome and its components, cardiovascular diseases, TCF7L2 gene rs1225537 polymorphism

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