HEMOSTATIC FUNCTION IN PATIENTS WITH THYROID DISEASE
https://doi.org/10.18705/2311-4495-2014-0-3-57-61
Abstract
The aim of the study. Investigate the state of the plasma hemostasis in patients with thyroid disease and different levels of thyroid function. Material and methods. The study included 68 patients with thyroid disease, divided into three groups based on the functional state of the thyroid gland: 31 patients with hypothyroidism, 17 patients with diffuse toxic goiter with manifestations hyperthyroidism, 20 patients in euthyroid (nodular nontoxic goiter). All patients underwent detailed coagulation hemostasis on an automated analyzer STA Compact (Roche) reagents company «Diagnostica Stago» before treatment and on the background of therapy. Results. In patients with hypothyroidism showed a significant decrease in the activity of Factor VIII, concentration of von Willebrand factor antigen, aPTT prolongation. In patients with hyperthyroidism showed a significant increase in the activity of factor VIII, concentration of D-dimer, activity of antithrombin. Conclusions. In patients with hypothyroidism there is a reduction in the total procoagulant activity with the formation of acquired von Willebrand syndrome. In patients with hyperthyroidism, hypercoagulation occurs.
References
1. Дедов И.И. Эндокринология / И.И. Дедов, Г.А. Мельниченко, В.В. Фадеев. - М.: Медицина, 2000. - 632 с.
2. Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. - М.: ГЭОТАР-Медиа, 2007. - 422 с.
3. Шустов С.Б., Баранов В.Л., Халимов Ю.Ш. Клиническая эндокринология. - М.: Мед. информ. агенство, 2012. - 632 с.
4. Myrup B. Primary haemostasis in thyroid disease / B. Myrup, C. Bregengård, J. Faber // J. Intern. Med. - 1995. - Vol. 238, № 1. - Р. 59-63.
5. Homoncik M. Altered platelet plug formation in hyperthyroidism and hypothyroidism / M. Homoncik, A. Gessl, A. Ferlitsch et al. // J. Clin. Endocrinol. Metabol. - 2007. - Vol. 92, № 8. - Р. 3006-3012.
6. Гржибовский А.М. Анализ трех и более независимых групп количественных данных / А.М. Гржибовский // Экология человека. - 2008. - № 3. - С. 50-58.
7. Federici A.B. Acquired von Willebrand syndrome associated with hypothyroidism: a mild bleeding disorder to be further investigated // Semin. Thromb. Hemost. - 2011. - Vol. 37, № 1. - Р. 35-40.
8. Петрищев Н.Н. Физиология и патофизиология эндотелия. Дисфункция эндотелия. Причины, механизмы, фармакологическая коррекция / Н.Н. Петрищев, Т.Д. Власов. - СПб., 2003. - С. 4-138.
9. Galatiues S. Endothelin and von Willebrand factor as parameters of endothelial function in idiopathic dilated cardiomyopathy / S. Galatiues, H. Wroblewski, V.B. Sorensen et al. // Am. Heart. J. - 1999. - Vol. 137, № 3. - P. 549-554.
10. Lutze G., Naumann C., Zavta B. Полезные факты о коагуляции: вопросы и ответы / авт. пер. и ред. Т.В. Вавилова. - М.: Рош Диагностика Рус, 2009. - 150 с.
11. Vereberne H.J., Fliers E., Prummel M.F. еt al. Thyrotoxicosis as a predisposing factor for cerebral venous thrombosis // Thyroid. - 2000. - Vol. 10, № 7. - P. 607-610.
12. Graninger W., Pirich K. R., Speiser W. et al. Effects of thyroid hormones on plasma protein concentrations in man // J. Clin. Endocrinol. Metab. - 1986. - Vol. 63. - Р. 407-411.
13. Shih C.H., Chen S.L., Yen C.C. Thyroid hormone receptor-dependent transcriptional regulation of fibrinogen and coagulation proteins / C.H. Shih, S.L. Chen, C.C. Yen et al. // Endocrinology. - 2004. - Vol. 145, № 6. - P. 2804-2814.
14. Michiels J.J., Schroyens W., Berneman Z. et al. Acquired von Willebrand syndrome type 1 in hypothyroidism: reversal after treatment with thyroxine // Clin. Appl. Thromb. Hemost. - 2001. - Vol. 7, № 2. - Р. 113-115.
15. Lison S., Dietrich W., Spannagl M. Review article: unexpected bleeding in the operating room: the role of acquired von Willebrand disease // Anesth. Analg. - 2012. - Vol. 114, № 1. - Р. 73-81.
Review
For citations:
Egorova E.N. HEMOSTATIC FUNCTION IN PATIENTS WITH THYROID DISEASE. Translational Medicine. 2014;(3):57-61. (In Russ.) https://doi.org/10.18705/2311-4495-2014-0-3-57-61
Views:
855
Email this article 