THE ROLE OF GENERAL ANESTHETICS IN MODULATION OF THE SYSTEMIC INFLAMMATION RESPONSE DURING PERIOPERATIVE PERIOD
https://doi.org/10.18705/2311-4495-2017-4-5-28-36
Abstract
General anesthetics affect the immune system. Such immunomodulation can have both a negative and a positive effect on the outcome of surgical intervention and distant treatment results. Current review is devoted to the discussion and systematization of data on deregulation of the immune system in the perioperative period, the effects of some of the most common anesthetics on the immune cells and cytokines, as well as possible clinical manifestations of immunomodulation using general anesthetics.
About the Authors
I. A. Savvina
Almazov National Medical Research Centre
Russian Federation
MD, PhD, Almazov National Medical Research Centre, chief research scientist of Russian Polenov Neurosurgical Institute, associate professor, North-West State Mechnikov Medical University, professor of the chair of anaesthesiology and reanimatology named after V.L.Vanevskiy;
Russian Federation
MD, PhD, Almazov National Medical Research Centre, chief research scientist of Russian Polenov Neurosurgical Institute, associate professor, North-West State Mechnikov Medical University, professor of the chair of anaesthesiology and reanimatology named after V.L.Vanevskiy;
A. A. Kostareva
Almazov National Medical Research Centre
Russian Federation
MD, PhD, Director of the Institute of molecular biology and genetics, Almazov National Medical Research Centre;
Russian Federation
MD, PhD, Director of the Institute of molecular biology and genetics, Almazov National Medical Research Centre;
A. V. Fedorov
Almazov National Medical Research Centre
Russian Federation
PhD, Head of the laboratory of molecular and cellular mechanisms of atherosclerosis, Institute of molecular biology and genetics, Almazov National Medical Research Centre;
Russian Federation
PhD, Head of the laboratory of molecular and cellular mechanisms of atherosclerosis, Institute of molecular biology and genetics, Almazov National Medical Research Centre;
R. V. Rutkovskiy
Almazov National Medical Research Centre
Russian Federation
Head of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;
Russian Federation
Head of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;
D. A. Rasputina
Almazov National Medical Research Centre
Russian Federation
anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;
Russian Federation
anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre;
A. M. Malkhozova
Almazov National Medical Research Centre
Russian Federation
anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre
Russian Federation
anaesthesiologist-reanimatologist of the department of anaesthesiology, reanimatology and intensive care, Almazov National Medical Research Centre
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Review
For citations:
Savvina I.A., Kostareva A.A., Fedorov A.V., Rutkovskiy R.V., Rasputina D.A., Malkhozova A.M. THE ROLE OF GENERAL ANESTHETICS IN MODULATION OF THE SYSTEMIC INFLAMMATION RESPONSE DURING PERIOPERATIVE PERIOD. Translational Medicine. 2017;4(5):28-36. (In Russ.) https://doi.org/10.18705/2311-4495-2017-4-5-28-36
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