Preview

Translational Medicine

Advanced search

ELECTROCARDIOGRAPHIC MARKERS OF CARDIOMYOCYTES’ ACTION POTENTIALS LENGTHENING IN THE BORDER ZONE OF ISCHEMIA (EXPERIMENTAL AND MODEL STUDY)

https://doi.org/10.18705/2311-4495-2017-4-2-71-77

Abstract

Background: Ventricular fibrillation within the first 5 min of reperfusion was observed in the animals with lengthening but not shortening of action potential duration (APD) in the border zone of ischemia. Objective: The objective of the study was to find the electrocardiographic manifestations of the APD changes in the border zone of ischemia as the markers of ventricular fibrillation. Design and methods: The simulations were carried out using the model of the cat heart ventricles. To simulate the ischemia, we decreased activation velocity and modified the durations and the amplitudes of action potentials. Results: The simulations showed that APD’s increase in the border zone of ischemia was detectable in the ECG leads most proximal to the heart (V2,V3). It was manifested by the T-wave lengthening and the change of its polarity in the terminal period of repolarization. The similar T-wave features were observed in the electrograms of cats with the reperfusion ventricular fibrillation Conclusion: The simulation data can be useful for the development of new methods of diagnostics of the most dangerous types of ischemia associated with ventricular fibrillation.

About the Authors

Natalia V. Arteyeva
Institute of Physiology, Komi Science Center, Ural Division, Russian Academy of Sciences, Syktyvkar
Russian Federation
Phd, senior researcher of the laboratory of heart physiology


Olesya G. Bernikova
Institute of Physiology, Komi Science Center, Ural Division, Russian Academy of Sciences, Syktyvkar; Medical Institute of Pitirim Sorokin Syktyvkar State University, Syktyvkar
Russian Federation
PhD, assistant professor, senior researcher of the laboratory of heart physiology


Ksenia A. Sedova
Institute of Physiology, Komi Science Center, Ural Division, Russian Academy of Sciences, Syktyvkar; Czech Technical University in Prague, Kladno

PhD, senior researcher of the laboratory of heart physiology

researcher of the department of biomedical technology of the faculty of biomedical engineering



Jan E. Azarov
Institute of Physiology, Komi Science Center, Ural Division, Russian Academy of Sciences, Syktyvkar; Medical Institute of Pitirim Sorokin Syktyvkar State University, Syktyvkar
Russian Federation
Dr of Sci., assistant professor, director of the laboratory of heart physiology


References

1. Holland RP, Brooks H. The QRS complex during myocardial ischemia. An experimental analysis in the porcine heart. J Clin Invest. 1976; 57(3):541–550.

2. Spekhorst H, SippensGroenewegen A, David GK et al. Body surface mapping during percutaneous transluminal coronary angioplasty. QRS changes indicating regional myocardial conduction delay. Circulation. 1990; 82(3): 879–896.

3. Di Diego JM, Antzelevitch C. Acute myocardial ischemia: Cellular mechanisms underlying ST segment elevation. J Electrocardiol. 2014; 47(4):486–490.

4. Rodriguez B, Trayanova N, Noble D. Modeling Cardiac Ischemia. Ann N Y Acad Sci. 2006; 1080:395–414.

5. Alexandre J, Schiariti M, Rouet R et al. Rabbit ventricular myocardium undergoing simulated ischemia and reperfusion in a double compartment tissue bath: a model to investigate both antiarrhythmic and arrhythmogenic likelihood. Int J Physiol Pathophysiol Pharmacol. 2013; 5(1):52–60.

6. Lukas A, Antzelevitch C. Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current. Circulation. 1993; 88(6):2903–2915.

7. Piktel JS, Rosenbaum DS, Wilson LD. Mild Hypothermia Decreases Arrhythmia Susceptibility in a Canine Model of Global Myocardial Ischemia. Crit Care Med. 2012; 40(11): 2954–2959.

8. Bernikova OG, Sedova KA, Azarov YE et al. Ventricular myocardial repolarization in acute coronary occlusion and reperfusion in cats. Dokl Biol Sci. 2011; 437:69–71.

9. Arteyeva NV, Goshka SL, Sedova KA et al. What does the T(peak)-T(end) interval reflect? An experimental and model study. J Electrocardiol. 2013; 46(4):296 e1-e8.

10. Arteyeva NV, Azarov JE, Vityazev VA et al. Action potential duration gradients in the heart ventricles and the cardiac electric field during ventricular repolarization (a model study). J Electrocardiol. 2015; 48(4):678–685.

11. Kimura S, Bassett AL, Kohya T et al. Simultaneous recording of action potentials from endocardium and epicardium during ischemia in the isolated cat ventricle: relation of temporal electrophysiologic heterogeneities to arrhythmias. Circulation. 1986; 74(2):401–409.

12. Sedova K, Bernikova O, Azarov J et al. Effects of echinochrome on ventricular repolarization in acute ischemia. J Electrocardiol. 2015; 48(2):181–186.

13. van Dam PM, Oostendorp TF, van Oosterom A. Application of the fastest route algorithm in the interactive simulation of the effect of local ischemia on the ECG. Med Biol Eng Comput. 2009; 47:11–20.

14. MacLachlan MC, Sundnes J, Lines GT. Simulation of ST Segment Changes During Subendocardial Ischemia Using a Realistic 3-D Cardiac Geometry. IEEE Trans Biomed Eng. 2005; 52(5):799–807.

15. Bacharova L, Szathmary V, Mateasik A. QRS complex and ST segment manifestations of ventricular ischemia: The effect of regional slowing of ventricular activation. J Electrocardiol. 2013; (46): 497–504.


Review

For citations:


Arteyeva N.V., Bernikova O.G., Sedova K.A., Azarov J.E. ELECTROCARDIOGRAPHIC MARKERS OF CARDIOMYOCYTES’ ACTION POTENTIALS LENGTHENING IN THE BORDER ZONE OF ISCHEMIA (EXPERIMENTAL AND MODEL STUDY). Translational Medicine. 2017;4(2):71-77. (In Russ.) https://doi.org/10.18705/2311-4495-2017-4-2-71-77

Views: 914


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2311-4495 (Print)
ISSN 2410-5155 (Online)