PRIMARY DIAGNOSIS OF SEPSIS IN PATIENTS RECEIVING MEDICINAL TREATMENT FOR ONCOLOGICAL DISEASE: COMPARISON OF SIRS AND SOFA CRITERIA

Introduction: Sepsis as a complication of chemotherapy has significant negative impact on life duration and cancer treatment cost. Immediate diagnostics is a key factor in reducing sepsis related mortality. Criteria based on systemic inflammatory response syndrome (SIRS) or sequential organ failure assessment (SOFA) are used for sepsis diagnosis alternatively.

Objective: determination of the usefulness of SIRS and SOFA criteria as screening for sepsis in patients receiving antitumor therapy for advanced malignant tumors.

Materials and methods: A cohort retrospective study of the main operational characteristics of diagnostic methods for diagnosis of sepsis is based on the results of treatment of 102 cancer patients with infection and various chemotherapy-association complications.

Results: Sepsis was defined in 33% of patients with infectious complications. The sensitivity of SIRS criteria was 0.79 (95% confidence interval (CI) 0.63-0.90), specificity 0.41 (CI 0.30-0.53), test accuracy 0.54 (CI 0.40- 0.68). The sensitivity of SOFA criteria was 0.85 (CI 0.70-0.94), specificity 0.68 (CI 0.56-0.76), test accuracy 0.74 (CI 0.60-0.85).

Conclusion: The sensitivity of the SOFA criteria for the detection of sepsis in patients receiving antitumor treatment is close to the sensitivity of the SIRS criteria with significantly higher specificity and predictive value. In this regard, the use of the SOFA criteria in such patients seems more useful.

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