ИЗМЕНЕНИЕ УРОВНЕЙ ЦИРКУЛИРУЮЩИХ МИКРОРНК ПРИ ПАТОГЕНЕЗЕ ГЕНЕТИЧЕСКИ ОБУСЛОВЛЕННОГО САХАРНОГО ДИАБЕТА ВЗРОСЛЫХ У МОЛОДЫХ

Сахарный диабет взрослого типа у молодых или MODY-диабет представляет собой моногенную форму диабета, возникающую при генетических нарушениях функционирования β-клеток поджелудочной железы. Сложность диагностирования данного типа диабета состоит в мягком проявлении заболевания и перекрывании клинических симптомов MODY-диабета с симптомами диабетов других типов. Одним из основных критериев постановки диагноза MODY-диабет является обнаружение мутации в генах, связанных с механизмами регуляции синтеза и секреции инсулина. Диагностика MODY-диабета позволяет применять более специфичные схемы лечения, а также выявлять новые случаи данного заболевания, проверяя родственников пациентов. Перспективную группу новых биомаркеров для ранней диагностики данного заболевания представляют собой циркулирующие микроРНК. Данная статья посвящена обзору имеющейся на сегодняшний день информации о микроРНК, уровни которых в биологических жидкостях позволяют выявлять пациентов с различными типами MODY-диабета.

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