SCREENING FOR HYPERCOAGULABILITY IN SEPSIS
https://doi.org/10.18705/2311-4495-2016-3-5-34-41
Abstract
Background. Overt disseminated intravascular coagulation (DIC) is independent risk factor in sepsis. Hypercoagulability, present in pre-DIC state, is hardly detected by available screening tests. T hromboelastometry (TEM) and thrombin generation test (TG) showed contradictory results in sepsis.
Objectives. The aim of the study is to compare the screening potential of T EM, TG and local tests to detect hypercoagulability in sepsis.
Design and methods. TEM screening of septic patients revealed hypercoagulability in 21 cases. T G test were performed along with screening coagulation tests and physiological anticoagulants.
Results. There was no thrombin generation in 2 of 21 cases. Increased ETP and Peak revealed only in one case. T he degree of T M-modulated suppression of T G was abnormally low in 15 cases out of 19. Median ETP suppression was only 14% [8,8–24], Peak suppression was 8% [3,4–12,5]. T hus, T EM- identified hypercoagulability was confirmed by both T G and TM+TG tests only in 16 cases (84.2%). Dynamic T EM-criteria (CFT intem) highly correlated with ETP- and PTsuppression values.
Conclusion. Hypercoagulability during sepsis is often due to abnormality in PC pathway. TEM appears to be sensitive POC tool to detect hypercoagulability in sepsis.
About the Authors
V. V. Osovskikh
Federal state budgetary institution «Russian scientific center of radiology and surgical technologies» of the ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
PhD, head of the group of Anesthesiology and intensive care
Leningradskaya str., 70 Pesochniy pos., Saint Petersburg, Russia, 197758
M. S. Vasilieva
Federal Almazov North-West Medical Research Centre
Russian Federation
clinical intern
Russian Federation
clinical intern
E. V. Kraisvetnaia
Federal state budgetary institution «Russian scientific center of radiology and surgical technologies» of the ministry of healthcare of the Russian Federation
Russian Federation
Russian Federation
physician at Anesthesiology and intensive care unit
A. E. Bautin
Federal Almazov North-West Medical Research Centre
Russian Federation
Russian Federation
PhD, head of the laboratory of Anesthesiology and intensive care
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Review
For citations:
Osovskikh V.V., Vasilieva M.S., Kraisvetnaia E.V., Bautin A.E. SCREENING FOR HYPERCOAGULABILITY IN SEPSIS. Translational Medicine. 2016;3(5):34-41. (In Russ.) https://doi.org/10.18705/2311-4495-2016-3-5-34-41
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