BRIEF PROTOCOLS OF SOUND PRECONDITIONING INHIBIT CISPLATIN-INDUCED OTOTOXICITY IN RATS
https://doi.org/10.18705/2311-4495-2016-3-4-90-96
Abstract
Objective. In this study, we compared the effectiveness of different protocols of sound preconditioning against cisplatin-induced ototoxicity. Materials and methods. Laboratory rats were subjected to different protocols of acoustic stimulation before intravenous injection of cisplatin at a dose of 7 mg/kg. The functional state of inner ear was evaluated using otoacoustic emission. Results. Minimal depression of otoacoustic emission amplitude tracing on the third day after cisplatin injection was registered in the group subjected to the following sound preconditioning protocol: tonal signal 5 kHz, intensity 100 dB, continuous period of 15 minutes. Conclusion. The result obtained indicates that sound preconditioning could be recommended for prevention of ototoxicity-mediated hearing loss in the clinical settings.
About the Authors
S. A. Ivanov
Federal Almazov North-West Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
S. G. Zhuravsky
Federal Almazov North-West Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
M. M. Galagudza
Federal Almazov North-West Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
References
1. Roland P.S, John A, Rutka M.D. Ototoxicity. Decker B.C., ON: Elsevier, 2004. p. 220.
2. Bokemeyer C, Berger CC, Hartmann J.T. et al. Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer. Br. J. Cancer. 1998; 77(8):1355-1362.
3. Felix D. Rational pharmacotherapy of the inner ear. Advances in Oto-Rhino-Laryngology. Basel: Karger. 2002. p.168.
4. Журавский С.Г., Галагудза М.М., Просвирнина М.С. и др. Феномены пре- и посткондиционирования: от старого принципа к новой стратегии терапии. Бюллетень ФЦ-СКЭ им. В. А. Алмазова. 2012; 5(16):16-29
5. Галагудза М.М., Некрасова М.К., Сыренский А.В. и др. Устойчивость миокарда к ишемии и эффективность ишемического прекондиционирования при экспериментальном сахарном диабете. Российский физиологический журнал им. И. М. Сеченова. 2006; 92(3):284-291
6. Cheung M.M, Kharbanda R.K, Konstantinov I.E. et al. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J. Am. Coll. Cardiol. 2006; 47(11): 2277-2282.
7. Faries P.L, DeRubertis B, Trocciola S. et al. Ischemic preconditioning during the use of the PercuSurge occlusion balloon for carotid angioplasty and stenting. Vascular. 2008; 16(1): 1-9.
8. Desai K.K, Dikdan G.S, Shareef A. et al. Ischemic preconditioning of the liver: a few perspectives from the bench to bedside translation. Liver Transpl. 2008; 14:15691577.
9. Miller J.D, Watson C.S, Covell W.P. Deafening effects of noise on the cat. Acta Otolaryngol Suppl. 1963; 176: 1-91.
10. Theneshkumar S, Lorito G, Giordano P. et al. Effect of noise conditioning on cisplatin-induced ototoxicity: a pilot study. Med Sci Monit. 2009; 15(7): 173-177.
11. Иванов С.А., Журавский С.Г., Галагудза М.М. Цисплатиновая ототоксичность. Вестник оториноларингологии. 2012; 4:82-87
12. Иванов С.А, Журавский С.Г, Галагудза М.М. Молекулярные механизмы отопротекции в условиях феномена звукового прекондиционирования (обзор литературы). Бюллетень ФЦСКЭ им. В. А. Алмазова. 2013; 6(23):69-76
13. Subramaniam M, Campo P, Henderson D. The effect of exposure level on the development of progressive resistance to noise. Hear Res. 1991; 52:181-188.
14. Henselman L.W, Henderson D, Subramaniam M. et al. The effect of ‘conditioning’ exposures on hearing loss from impulse noise. Hear Res. 1994; 78(1):1-10.
Review
For citations:
Ivanov S.A., Zhuravsky S.G., Galagudza M.M. BRIEF PROTOCOLS OF SOUND PRECONDITIONING INHIBIT CISPLATIN-INDUCED OTOTOXICITY IN RATS. Translational Medicine. 2016;3(4):90-96. (In Russ.) https://doi.org/10.18705/2311-4495-2016-3-4-90-96
Views:
606
Email this article 