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CORRECTION OF THROMBOEMBOLIC COMPLICATIONS IN ENDOVASCULAR EMBOLIZATION

https://doi.org/10.18705/2311-4495-2016-3-1-98-105

Abstract

Objective. To analyze the thromboembolic complications of endovascular neurosurgical operations and the results of their treatment. Materials and Methods: During the period from 2010 to 2014 in the Department of Vascular Surgery of the brain endovascular interventions performed in 2415 patients, 28 (1,16 %) of them developed thromboembolic complications. In order to restore patency of cerebral arteries of 22 patients underwent selective intra-arterial injection of the Actilyse drug, with thrombolysis supplemented by mechanical disruption of the thrombus. 6 patients performed trombekstraktsiya with intracranial self-expanding stent «Solitaire ™ FR Revascularization Device». Results. Complete recanalization was achieved in 25 (89,2 %) of the 28 cases acute thrombosis of intracranial arteries arising during endovascular surgery, in 3 cases there was a partial recanalization. Retromboz artery in one day was detected in 2 patients undergoing aneurysm embolization coils with stent-assistend. Both patients showed a lack of inhibition of platelet aggregation during treatment with dual antiplatelet therapy. There was not Hemorrhagic complications of fibrinolytic therapy. Conclusions. During the endovascular interventions to reduce the risk of thromboembolic complications requires careful preoperative preparation of the patient, assessment of the blood coagulation system and sensitivity to antiplatelet agents. Application of trombekstraktor and thrombolytic therapy to restore patency of intracranial arteries is effective (recanalization was achieved in 89,2 % of cases).

About the Authors

L. V. Rozhchenko
Polenov Neurosurgical Institute
Russian Federation


A. Yu. Ivanov
Polenov Neurosurgical Institute
Russian Federation


N. V. Dryagina
Polenov Neurosurgical Institute
Russian Federation


A. E. Petrov
Polenov Neurosurgical Institute
Russian Federation


S. A. Goroshchenko
Polenov Neurosurgical Institute
Russian Federation


C. D. Radzhabov
Polenov Neurosurgical Institute
Russian Federation


M. I. Khristoforova
Polenov Neurosurgical Institute
Russian Federation


A. A. Ivanov
Polenov Neurosurgical Institute
Russian Federation


References

1. Максименко А.В. Активаторы плазминогена третьего поколения. Новое направление изучения. Биоорганическая химия. 1999; 25(8): 563-571

2. Максименко А.В., Тищенко Е.Г. Комбинированный тромболизис - новое направление исследования активаторов плазминогена третьего поколения. Вопросы биологической медицинской и фармалогической химии. 2000; 1: 1-10

3. Панченко Е.П. Тромболитические средства. Часть 3. Клиническая фармакология и терапия. 1998; 7: 84-88

4. Рожченко Л.В. Тромболитическая терапия в современной нейрохирургической практике. www.hem-aids.ru/system/files/ attachments/1256/new_newmet_032.doc.

5. Рожченко Л.В. Активаторы плазминогена в лечении цереброваскулярных заболеваний. Химико-фармацевтический журнал. 2003; 37(6): 3-14

6. Щеглов В.И., Щеглов Д.В., Конотопчик С.В., Свиридюк О.Е. Тромбоэмболические осложнения при эндоваскулярных окклюзиях мешотчатых аневризм и методы их лечения. Біль, знеболювання i інтенсивна терапія. 2013; 2: 7-15

7. Barnwell S.L, Clark W.M, Nguyen T.T. O’Neill O.R, Wynn M.L, Coull B.M. Safety and efficacy of delayed intraarterial urokinase therapy with mechanical clot disruption for thromboembolic stroke. AJNR Am J Neuroradiol. 1994; 5: 1817-1822.

8. Chen M. A checklist for cerebral aneurysm embolization complications Journal of NeuroInterventional Surgery. 2013; 5(1): 20-27.

9. Chris G, Kostner K. Plasmin activation system in restenosis: role in pathogenesis and clinical prediction? J Tromb Trombolysis.1999; 3: 277-285.

10. Cronqvist M, Pierot L, Boulin A, Cognard C, Castaings L, Moret J. Local intraarterial fibrinolysis of thromboemboli occurring during endovascular treatment of intracerebral aneurysm: A comparison of anatomic results and clinical outcome. AJNR Am J Neuroradiol. 1998; 19: 157-165.

11. Kayimoto Y, Ohta T. Comparison of intrathecally administred urokinase, tissue-type plasminogen activatir, and combination of urokinase and lysine plasminogen for clot lysis after experimental subarachnoid hemorrhage in dogs. Neurosurg. 1997; 40(3): 572-577.

12. Kesava P, Graves V, Salamat S, Rappe A. Intraarterial thrombolysis in a pig model: A preliminary note. AJNR Am J Neuro-radiol. 1997; 18: 915-920.

13. Komiyama M, Nishio A, Nishijiyama Y. Endovascular treatment of acute thrombotic occlusion of the cervical internal carotid artery asssociated with embolic occlusion of the middle cerebral artery: case report. Neurosurg. 1994; 2: 359-364.

14. Liang J.F, Li Y, Yand V.C. The potential mechanism for the effect of heparin on tissue plasminogen activator-mediated plasminogen activation. Tromb Res. 2000; 97(5): 439-358.

15. McDougall C, Clark W, Mayer T. et al. The Penumbra Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in acute ischemic stroke. Proceedings of the International Stroke Conference, New Orleans. 2008.

16. Nogueira R.G, Schwamm L.H, Hirsch J.A. Endovascular approaches to acute stroke, part 1: drugs, devices, and data AJNR. 2009; 30: 649-661.

17. Qureshi A.I, Luft A.R, Sharna M, Guterman L.R, Horkins L.N. Prevention and treatment of tromboembolic and ischemic complications associated with Endovacular Procedures: Part I - Pathophysiological and pharmocological Features. Neurosurgery. 2000; 46(6): 1344-1359.

18. Sasaki O, Takeuchi S, Keikc T, Keizumi T, Tanaka R. Fibrinolytic therapy for acute embolic stroke: intravenous, intracarolid and intra-arterial local approaches. Neurosugery. 1995; 36: 246-253.

19. Smith W.S, Sung G, Starkman S, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: Results of the merci trial Stroke. 2005; 36: 14321438.

20. Wardlaw J.M, Warlow C.P, Counsell C. Systematic review ol evidence on thrombolytic therapy for acute ischaemic stroke. Lancet. 1997; 350: 607-614.

21. Zeumer H, Frcitag H.I, Thic A, Arning C. Local intra-arterial fibrinolytic therapy in patients with stroke: urokinase versus re-combinant tissue plasminogen activalor (r-TPA) Neuroradiology.1993; 35: 159-162.


Review

For citations:


Rozhchenko L.V., Ivanov A.Yu., Dryagina N.V., Petrov A.E., Goroshchenko S.A., Radzhabov C.D., Khristoforova M.I., Ivanov A.A. CORRECTION OF THROMBOEMBOLIC COMPLICATIONS IN ENDOVASCULAR EMBOLIZATION. Translational Medicine. 2016;3(1):98-105. (In Russ.) https://doi.org/10.18705/2311-4495-2016-3-1-98-105

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ISSN 2311-4495 (Print)
ISSN 2410-5155 (Online)