THE NEUROGENIC ADRENERGIC MECHANISMS ARE INVOLVED IN THE PULMONARY HEMODYNAMICS AND CARDIAC OUTPUT CHANGES FOLLOWING MYOCARDIAL ISCHEMIA
https://doi.org/10.18705/2311-4495-2014-0-1-98-104
Abstract
Background. There are no obvious data concerning the mechanisms of the active reactions of the pulmonary vessels following myocardial ischemia, which are important for fundamental and clinical medicine. Objective. The investigations of the neurogenic mechanisms in the pulmonary hemodynamics changes following experimental myocardial ischemia. Design and methods. In acute experiments in anesthetized rabbits the changes of the pulmonary hemodynamics and cardiac output were studied following 60 s myocardial ischemia in the region of the descendent left coronary artery in control animals and after the blockade of α-adrenoreceptors by phentolamine or M-cholinoreceptors by atropine. Results. Following myocardial ischemia: 1) in control animals the pulmonary artery pressure decreased, the cardiac output diminished more, than the pulmonary artery flow; 2) after the blockade of α-adrenoreceptors the pulmonary artery flow and cardiac output decreased in the same level; 3) after the blockade of M-cholinoreceptors the pulmonary hemodynamics changes were the same as in the control rabbits, the cardiac output decreased twice more than the pulmonary artery flow. Conclusion. The neurogenic adrenergic mechanisms are involved in active pulmonary vessel reactions which led to the disbalance of the cardiac output and pulmonary artery flow changes in the case of the left ventricular myocardial ischemia.
About the Authors
Vadim I. Evlakhov
Institute of Experimental Medicine of the North-West Department Russian Academy of Medical Sciences
Russian Federation
Russian Federation
I. Z. Poyassov
Institute of Experimental Medicine of the North-West Department Russian Academy of Medical Sciences
Russian Federation
Russian Federation
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Review
For citations:
Evlakhov V.I., Poyassov I.Z. THE NEUROGENIC ADRENERGIC MECHANISMS ARE INVOLVED IN THE PULMONARY HEMODYNAMICS AND CARDIAC OUTPUT CHANGES FOLLOWING MYOCARDIAL ISCHEMIA. Translational Medicine. 2014;(1):98-104. (In Russ.) https://doi.org/10.18705/2311-4495-2014-0-1-98-104
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