Association of genetic variants of hemostasis system genes with a burdened obstetric-gynecological history in women and venous thrombosis during gestation

Background. One of the types of disorders in the hemostasis system is gestational thrombophilia. Therefore, it is important to understand the etiopathogenesis of this pathological condition, including the contribution of hereditary factors. Objective. To analyze the association of 8 genetic variants of the hemostasis system genes in women with gestational thrombophilia. Materials and methods. The study included 311 women aged 20 to 38 years outside pregnancy, who had at least 1 previous pregnancy with complicated obstetric and gynecological history, and gestational venous thrombosis of various localizations was detected during gestation, and 225 women in the control group. The genotypes of the selected genetic variants were studied by real-time PCR. Results. A positive association was found for 4 genetic variants: 20210 G>A of the F2 gene (GA + AA) (OR = 11.03 (95 % CI: 2.60–46.81), P < 0.001); 1691G>A of the F5 gene (GA + AA) (OR = 6.02 (95 % CI: 2.52–14.38), P < 0.001); -455 G>A of the FGB gene (AA) (OR = 5.65 (95 % CI: 3.05–10.45), P < 0.001) and -675 5G>4G of the PAI-1 gene (4G/4G) (OR = 2.28 (95 % CI: 1.54–3.39), P < 0.001). Conclusion. Thus, we established an association of 4 genetic variants of the genes of plasma hemostasis factors with a hereditary predisposition to AGA in women against the background of the development of gestational venous thrombosis.

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