Polymorphism of ApoE, ACE, NOS3 genes and features of the clinical course of the disease in previously stented patients with recurrent myocardial infarction

Purpose of the study: taking into account the polymorphism of the APOE, ACE, NOS3 genes, to compare the clinical course of recurrent myocardial infarction in individuals with thrombosis/stenosis in a previously established stent and in people with impaired coronary artery patency outside it.

Materials and Methods. We examined 212 patients treated for MI. All the patients were divided into two groups: (I) — 110 patients with patency disorder of the previously installed stent, (II) — off-stent stenosis — 102 patients. The samples were comparable by age and sex. The obtained data were statistically processed.

Results. Comorbid diseases were more common in patients with impaired patency of a previously installed stent. These people had a lower left ventricular ejection fraction, chronic heart failure, supraventricular and ventricular arrhythmias in the hospital period were more often recorded. At the same time, polymorphisms of ACE, APOE, and NOS3 genes were more common in patients with stent thrombosis/stenosis.

Conclusion. Presence of comorbid diseases increased the risk of stent obstruction. A more severe course of recurrent MI in patients with stenosis/thrombosis of a previously placed stent increased mortality 3-fold. Polymorphic variants of ACE, APOE, NOS3 genes can be considered as predictors of recurrent MI development on the background of the previously installed stent patency failure with a more severe hospital course.

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