KISSPEPTIN SIGNALING IN MENSTRUAL DISORDERS IN OBESE ADOLESCENT GIRLS
https://doi.org/10.18705/2311-4495-2023-10-3-154-165
Abstract
Background. Menstrual cycle disorders (MCD) are common among adolescent girls.
Objective. To study the level of plasma kisspeptin in adolescent girls with obesity and MCD.
Design and methods. The study included 80 adolescent girls with obesity. Group 1 — with MCD, group 2 — without MCD. Inclusion in groups 1 year or more after menarche. Laboratory examination included assessment of carbohydrate and lipid metabolism, hormonal examination.
Results. There were no significant differences in SDS BMI between the groups (p = 0.486 and p = 0.459). Significantly higher in group 1: impaired carbohydrate tolerance (NTU), hypertriglyceridemia (p = 0.022), levels of kisspeptin, luteinizing hormone (LH), total testosterone, anti-muller hormone (AMH), free androgen index (ISA) (p = 0.001, p = 0.008, p = 0.026, p = 0.014, p = 0.027, respectively). The estradiol level in group 2 was significantly higher than in group 1 (p = 0.012). According to the results of the ROC analysis, the optimal value of the plasma kisspeptin level was found to be 53.56 pg/ml.
Conclusion. Obese and MCD patients have significantly higher levels of kisspeptin, as well as LH, AMH, and testosterone than adolescent girls with similar severity of obesity without MCD. The plasma kisspeptin level is 53.56 pg/ml. It can be used as a new diagnostic criterion for predicting the risk of MCD in obese girls. Obese and MCD patients are significantly more likely to have NTU and hypertriglyceridemia compared to obese patients without MCD.
Supporting agencies: State task number 2021-42 “Development of a new drug for the treatment of male hypogonadism” of the Research Laboratory of Pediatric Endocrinology of the Institute of Endocrinology, Federal Almazov National Medical Research Center, Saint-Petersburg, Russia.
About the Authors
A. S. Liskina
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Anastasia S. Liskina, Assistant of the Department of Children’s Diseases with a clinic of the Faculty of Medicine
Akkuratova str., 2, Saint Petersburg, 197341
E. Yu. Vasilieva
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Elena Yu. Vasilieva, Head of the Central Clinical Diagnostic Laboratory
Akkuratova str., 2, Saint Petersburg, 197341
I. E. Zazerskaya
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Irina E. Zazerskaya, D.M.Sc., Professor, Head of the Department of Obstetrics and Gynecology with Clinic
Akkuratova str., 2, Saint Petersburg, 197341
I. L. Nikitina
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Irina L. Nikitina, D.M.Sc., Professor, Head of the Department of Children’s Diseases with Clinic
Akkuratova str., 2, Saint Petersburg, 197341
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Review
For citations:
Liskina A.S., Vasilieva E.Yu., Zazerskaya I.E., Nikitina I.L. KISSPEPTIN SIGNALING IN MENSTRUAL DISORDERS IN OBESE ADOLESCENT GIRLS. Translational Medicine. 2023;10(3):154-165. (In Russ.) https://doi.org/10.18705/2311-4495-2023-10-3-154-165
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