Carlo method as the basis for in silico-modeling in the study of the pathogenesis of ischemic stroke.
https://doi.org/10.18705/2311-4495-2023-10-5-389-401
EDN: IGLVMJ
Abstract
The paper proposes a new mathematical model of dynamic processes in a typical spatially non-uniform biological system. The mathematical problem of modeling the dynamics of the neurovascular units of the brain under conditions of ischemic stroke is formulated and solved. An investigation of this model is conducted, and a numerical and programmatic implementation of the corresponding mathematical problem is proposed.
Supporting agencies: The work was supported by a grant from the Ministry of Science and Higher Education of the Russian Federation No. 075-15-2020- 792 (Unique identifier RF----190220X0031).
About the Authors
V. V. Fursov
N. I. Pirogov Russian National Research Medical University; D. I. Mendeleev Russian University of Chemical Technologies; Peoples' Friendship University of Russia named after Patrice Lumumba
Valentin V. Fursov, PhD, Associate Professor with the
Department of Physics, N. I. Pirogov Russian National
Research Medical University; Associate Professor with
the Department of Applied Mathematics, D. I. Mendeleev
Russian University of Chemical Technologies, Associate
Professor with the Institute of Physical Researsh &
Technologies of Peoples' Friendship University of Russia
S. V. Ananyev
D. I. Mendeleev Russian University of Chemical Technologie
Alexander V. Ananyev, M.Sc .(I.T), post graduate with the Department of Applied Mathematics, D. I. Mendeleev Russian University of Chemical Technologies
A. A. Bukhvostov
N. I. Pirogov Russian National Research Medical University
Alexander A. Bukhvostov, PhD, Associate Professor with the Department of Medical Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University
K. V. Ermakov
N. I. Pirogov Russian National Research Medical University
Kirill V. Ermakov, MD, Researcher with the Research
Division of Medical Nanobiotechnologies, N. I. Pirogov
Russian National Research Medical University;
D. A. Kuznetsov
N. I. Pirogov Russian National Research Medical University; N. N. Semenov Federal Research Center for Chemical Physics
Russian Federation
Russian Federation
Dmitry A. Kuznetsov, MD, D.Sc., Ordinary Professor with the Department of Medical Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University; Leading Research Fellow with the Department of the Matter’s Structure, N. N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
Ostrovityanova str., 1, Moscow, 117997
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Review
For citations:
Fursov V.V., Ananyev S.V., Bukhvostov A.A., Ermakov K.V., Kuznetsov D.A. Carlo method as the basis for in silico-modeling in the study of the pathogenesis of ischemic stroke. Translational Medicine. 2023;10(5):389-401. (In Russ.) https://doi.org/10.18705/2311-4495-2023-10-5-389-401. EDN: IGLVMJ
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