Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2).
https://doi.org/10.18705/2311-4495-2023-10-6-549-556
EDN: LQCCTQ
Abstract
The paper investigates the role of the association of polymorphic variants of the tissue plasminogen activator inhibitor 1 (PAI-1) and angiotensin-converting enzyme (ACE) genes in 244 patients with coronavirus infection with varying degrees of disease severity (mild, moderate, and the group of deaths). The influence of the age factor in conjunction with various genotypes on the course of coronavirus infection is also being studied. An analysis of the frequencies of alleles and genotypes of ACE found statistically significant differences: the D allele is associated with the severity and outcome of COVID-19. The I/D genotype is associated with a milder course of the disease, while the D/D genotype increases the likelihood of death.
About the Authors
D. S. Bogdanov
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
Dmitry S. Bogdanov, adjunct of the Department of Naval Therapy
Akademika Lebedeva str., 6, Saint Petersburg, 194044
D. V. Cherkashin
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
Dmitry V. Cherkashin, professor, doctor of medical sciences, Head of the Department of Naval Therapy
V. A. Ulyatovsky
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Viktor A. Ulyatovsky, candidate of medical sciences, lecturer at the Department of Naval Therapy
K. S. Shulenin
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Konstantin S. Shulenin, professor, doctor of medical sciences, deputy Head of the Department of Naval Therapy
S. V. Efimov
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Semen V. Efimov, сandidate of medical sciences, lecturer at the Department of Naval Therapy
L. A. Myakoshina
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Liliya A. Myakoshina, senior laboratory assistant of the Research Center
S. A. Butsenko
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Sergey A. Butsenko, Head of the Clinical Department
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Review
For citations:
Bogdanov D.S., Cherkashin D.V., Ulyatovsky V.A., Shulenin K.S., Efimov S.V., Myakoshina L.A., Butsenko S.A. Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2). Translational Medicine. 2023;10(6):549-556. (In Russ.) https://doi.org/10.18705/2311-4495-2023-10-6-549-556. EDN: LQCCTQ
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