Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2).
https://doi.org/10.18705/2311-4495-2023-10-6-549-556
EDN: LQCCTQ
Abstract
The paper investigates the role of the association of polymorphic variants of the tissue plasminogen activator inhibitor 1 (PAI-1) and angiotensin-converting enzyme (ACE) genes in 244 patients with coronavirus infection with varying degrees of disease severity (mild, moderate, and the group of deaths). The influence of the age factor in conjunction with various genotypes on the course of coronavirus infection is also being studied. An analysis of the frequencies of alleles and genotypes of ACE found statistically significant differences: the D allele is associated with the severity and outcome of COVID-19. The I/D genotype is associated with a milder course of the disease, while the D/D genotype increases the likelihood of death.
About the Authors
D. S. Bogdanov
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
Dmitry S. Bogdanov, adjunct of the Department of Naval Therapy
Akademika Lebedeva str., 6, Saint Petersburg, 194044
D. V. Cherkashin
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Russian Federation
Russian Federation
Dmitry V. Cherkashin, professor, doctor of medical sciences, Head of the Department of Naval Therapy
V. A. Ulyatovsky
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Viktor A. Ulyatovsky, candidate of medical sciences, lecturer at the Department of Naval Therapy
K. S. Shulenin
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Konstantin S. Shulenin, professor, doctor of medical sciences, deputy Head of the Department of Naval Therapy
S. V. Efimov
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Semen V. Efimov, сandidate of medical sciences, lecturer at the Department of Naval Therapy
L. A. Myakoshina
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Liliya A. Myakoshina, senior laboratory assistant of the Research Center
S. A. Butsenko
Federal state budgetary military educational institution of higher education “Military Medical Academy named after S. M. Kirov” of the Ministry of defence of the Russian Federation
Sergey A. Butsenko, Head of the Clinical Department
References
1. Shishimorov IN, Magnitskaya OV, Ponomareva YV. Genetic predictors of the severity of the course and the effectiveness of pharmacotherapy of COVID-19. Pharmacy and pharmacology. 2021; 9(3):174–184. In Russian DOI: 10.19163/2307-9266-2021-93-174-184.
2. Sayed-Tabatabaei FA, et al. ACE polymorphisms. Circulation research. 2006;98(9): 1123–1133. DOI: 10.1161/01.RES.0000223145.74217.e7.
3. Timokhina EV, et. al. Polymorphism of the angiotensin-converting enzyme gene ACE significantly increases the risk of developing preeclampsia. Biochemistry. 2019;84(2):281–287. In Russian DOI 10.1134/S0320972519020118. – EDN YVEYAH.
4. Sun F, He N, Zhang K, et al. Association of ACE gene A2350G and I / D polymorphisms with essential hypertension in the northernmost province of China. Clin Exp Hypertens 2018;40(1):32–38. DOI: 10.1080/10641963. 2017.1291659.
5. Gong H, Mu L, Zhang T, et al. Association of polymorphisms of CYP11B2 gene-344C / T and ACE gene I / D with antihypertensive response to angiotensin receptor blockers in Chinese with hypertension. Journal of genetics. 2019;(98):1–5. DOI: 10.1007/s12041-018-1053-2.
6. Yamamoto N, et al. Angiotensin-converting enzyme (ACE) 1 gene polymorphism and phenotypic expression of COVID-19 symptoms. Genes. 2021;12(10):1572. DOI: 10.3390/genes12101572.
7. Urano T, et al. Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis. Current drug targets. 2019;20(16):1695–1701. DOI: 10.2174/1389450120666190715102510.
8. Shcherbak SG, et. al. Genetic polymorphism of the hemostasis system (literature review). Bulletin of the North-Western State Medical University I. I. Mechnikov. 2015;7(4):66–75. In Russian
9. Sillen M, Declerck PJ. A narrative review on plasminogen activator inhibitor-1 and its (patho) physiological role: to target or not to target? International journal of molecular sciences. 2021;22(5):2721. DOI: 10.3390/ijms22052721.
10. Parpugga TK, et al. The effect of PAI-1 4G/5G polymorphism and clinical factors on coronary artery occlusion in myocardial infarction. Disease markers. 2015; 2015: Article ID 26010. DOI: 10.1155/2015/260101.
11. Butsenko SA, Sergoventsev AA, Kuznetsova RYu, et al. Factors contributing to infection with a new coronavirus infection, increasing the risk of complications and death from it in the armed forces of the Russian Federation. Bulletin of the Russian Military Medical Academy. 2023;25(1):121–132. In Russian
12. Greenwood PE, Nikulin MS. A guide to chisquared testing. New York: Wiley, 1996. 280 p.
Review
For citations:
Bogdanov D.S., Cherkashin D.V., Ulyatovsky V.A., Shulenin K.S., Efimov S.V., Myakoshina L.A., Butsenko S.A. Influence of the age factor and АСЕ and PAI-1 gene polymorphism on the severity of the new coronavirus infection (SARS-CoV-2). Translational Medicine. 2023;10(6):549-556. (In Russ.) https://doi.org/10.18705/2311-4495-2023-10-6-549-556. EDN: LQCCTQ
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