Heat shock proteins as diagnostic and prognostic markers in malignant tumors of the central nervous system
https://doi.org/10.18705/2311-4495-2022-9-6-5-15
Abstract
This review overview current epidemiology data of malignant tumors of the central nervous system, and determines the significance of molecular diagnostics and expression of heat shock proteins in tumorigenesis. Particular attention is paid to the description of molecular chaperones as diagnostic and prognostic markers, as well as the prospects for chaperones using in personalized therapy the central nervous system tumors. The search for literature was carried out on the database platforms Medline (via PubMed) and Scopus, Cochrane Library, The Lancet Public Health Journal published between 1988 and 2022. The material was searched for keywords and terms, including “heat shock proteins”, “tumors of the central nervous system”, “brain tumors”, “molecular diagnostics”, “expression of molecular chaperones”, Hsp110, Hsp90, Hsp70, Hsp60, Hsp40, small HSPs. Molecular chaperones, due to their important role in physiological processes in the cell, are highly expressed in brain tumors, and the expression level of HSPs strongly correlates with the degree of malignancy, invasive potential, and resistance to radiochemotherapy. For some HSPs (i.e. HSP10, HSPB1, DNAJC10, HSPA7, HSP90) a direct correlation has been found between the level of protein expression (based on IHC analysis) and a poor overall survival prognosis for patients with glial tumors. This indicates the prognostic value of these markers, which in the future may be included in the diagnostic panel when examining a tumor sample.
Keywords
brain tumors,
heat shock proteins,
molecular chaperones,
molecular diagnostics,
therapy,
tumors of the central nervous system
Supporting agencies: The study was carried out with the support of the Ministry of Science and Higher Education of the Russian Federation and the Russian Academy of Sciences (Agreement No. 075-15-2022-301 от 20.04.2022).
About the Authors
E. T. Nazaralieva
Polenov Russian Scientific Research Institute of Neurosurgery
Russian Federation
Russian Federation
Eleonora T. Nazaralieva, MD, Researcher, Research Laboratory of Pediatric Neurosurgery
Akkuratova str., 2, Saint Petersburg, Russia, 197341
V. S. Fedorov
Institute of Cytology of the Russian Academy of Science
Russian Federation
Russian Federation
Vyacheslav S. Fedorov, senior laboratory assistantresearcher
Saint Petersburg
Yu. M. Zabrodskaya
Polenov Russian Scientific Research Institute of Neurosurgery
Yulia M. Zabrodskaya, ScD, Head of the Research Laboratory of Pathomorphology of the Nervous System
Saint Petersburg
A. V. Kim
Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicin
Russian Federation
Russian Federation
Alexander V. Kim, ScD, Associate Professor, Department of Neurosurgery, Head of the Children’s Neurosurgical Department № 7
Saint Petersburg
B. R. Djanaliev
Кыргызская государственная медицинская академия им. И.К. Ахунбаева
Kyrgyzstan
Kyrgyzstan
Bolot R. Djanaliev, ScD, Professor, Department of Pathological Anatomy
Bishkek
M. A. Shevtsov
Institute of Cytology of the Russian Academy of Science; Almazov National Medical Research Centre, World-Class Research Centre for Personalized Medicin
Russian Federation
Russian Federation
Maxim A. Shevtsov, ScD, Leading Researcher, Institute of Cytology of the Russian Academy of Sciences; Head of Research Center for Translational Oncology
Saint Petersburg
K. A. Samochernych
Polenov Russian Scientific Research Institute of Neurosurgery
Russian Federation
Russian Federation
Konstantin A. Samochernych, ScD, professor of the Russian Academy of Sciences, director, Head of the Research Center for Personalized Oncology, World-Class Research Centre for Personalized Medicine
Saint Petersburg
References
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Review
For citations:
Nazaralieva E.T., Fedorov V.S., Zabrodskaya Yu.M., Kim A.V., Djanaliev B.R., Shevtsov M.A., Samochernych K.A. Heat shock proteins as diagnostic and prognostic markers in malignant tumors of the central nervous system. Translational Medicine. 2022;9(6):5-15. (In Russ.) https://doi.org/10.18705/2311-4495-2022-9-6-5-15
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