Prognostic significance of changes in the level physical capacity to assess the favorable dynamics of metabolic syndrome in patients with abdominal obesity
https://doi.org/10.18705/2311-4495-2020-7-6-6-15
Abstract
Background. Abdominal obesity (AO) is a key factor of metabolic syndrome (MS) and risk factor of cardiovascular diseases (CVD). The level of physical capacity (PC) is an important diagnostic and prognostic criteria and a risk stratification factor in healthy individuals and patients with CVD. Objective. To evaluate the effect of changes in the level of PC on the course of MS in patients with AO on the background of non-drug correction of body weight. Design and methods. A 3-year prospective study was conducted on weight loss by non-drug methods in 153 patients with AO and MS and /or CVD risk factors. The dynamics of MS, indicators of carbohydrate and lipid metabolism, and blood pressure levels were evaluated depending on changes in the level of PC. Results. The favorable course of the MS was more common in patients with an increase in the level of PC than in patients with a decrease in this indicator (82.3 and 37.5 %, respectively; p = 0.0001). When increasing VO2peak > the 5 % to 15 % chance of a favorable course of MS increases by 5.8 (1.5–22.3) and 15.1 (5.7–39.9) times, respectively. Conclusion. An increase in the level of PC is associated with a favorable MS dynamic.
About the Authors
A. V. Berezina
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Berezina Aelita V., MD, Dr. Sci., Chief Researcher, Head of the Laboratory of Cardiopulmonary testing, Almazov National Medical Research Centre; Assistant, Department of Faculty Therapy, Academician I. P. Pavlov First Saint Petersburg State Medical University
Akkuratova str. 2, Saint Petersburg, 197341
O. A. Berkovich
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Bercovich Olga A., MD, Dr. Sci., Leading Researcher, Research Laboratory of Metabolic Syndrome, Institute of Endocrinology, Almazov National Medical Research Centre; Professor, Department of Faculty Therapy, Academician I. P. Pavlov First Saint Petersburg State Medical University
Saint Petersburg
O. D. Belyaeva
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Belyaeva Olga D., MD, Dr. Sci., Leading Researcher, Research Laboratory of Metabolic Syndrome, Institute of Endocrinology, Professor, Department of Internal Medicine, Institute of Medical Education, Almazov National Medical Research Centre; Professor, Department of Faculty Therapy, Academician I. P. Pavlov First Saint Petersburg State Medical University
Saint Petersburg
E. A. Bazhenova
Almazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Bazhenova Elena A., MD, PhD, Senior Researcher, Research Laboratory of Metabolic Syndrome, Institute of Endocrinology, Almazov National Medical Research Centre; Associate Professor, Department of Faculty Therapy, Academician I. P. Pavlov First Saint Petersburg State Medical University
Saint Petersburg
E. V. Kuleshova
Almazov National Medical Research Centre
Russian Federation
Russian Federation
Kuleshova Elvira V., MD, Dr. Sci., Professor, Chief Researcher, Coronary Artery Disease Research Department
Saint Petersburg
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Review
For citations:
Berezina A.V., Berkovich O.A., Belyaeva O.D., Bazhenova E.A., Kuleshova E.V. Prognostic significance of changes in the level physical capacity to assess the favorable dynamics of metabolic syndrome in patients with abdominal obesity. Translational Medicine. 2020;7(6):6-15. (In Russ.) https://doi.org/10.18705/2311-4495-2020-7-6-6-15
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