The relationship of food behavior and vascular aging on the example of a population selection of residents of St. Petersburg

Background. Diet and nutrition can favorably modulate arterial function during vascular aging, and therefore the search for their relationship is important.

Objective. To study the relationship between eating behavior and markers of early vascular aging in patients with prehypertension and arterial hypertension.

Design and methods. The respondents from the population sample of the epidemiological observational study ESSE-RF were questioned. 477 questionnaires were selected for further analysis of the respondents’ eating habits and the prevalence of early vascular aging among them. Inclusion criteria were age over 40 years to assess the risk of developing cardiovascular complications using the SCORE and ASCORE scales; lack of criteria for high and very high risk on the SCORE scale. A standard questionnaire was used, developed on the basis of adapted and validated international methods, with 12 modules. In the answers of the respondents, the amount and frequency of consumption of table salt, sugar, animal fats, meat and processed meat products, vegetables and fruits, poultry and fish were analyzed. The estimated vascular age of all respondents was assessed using the ASCORE scale.

Results. In total, the responses on eating behavior were analyzed in 295 women and 182 men aged 40 to 65 years; the estimated vascular age (ASCORE) was 55.5 ± 9.6 years. For respondents with healthy vascular aging, compared to respondents with premature vascular aging, significantly less salt (57.2% versus 70.6%), sausages (44.1% versus 27%) and higher consumption of poultry meat are typical (44.1% versus 13.9%), dairy products (73.6% versus 41.4%) and fresh vegetables / fruits (88.2% versus 58%). The group of people with healthy vascular aging showed a higher level of daily consumption of sweets (55.9% versus 30.5%).

Conclusion. Based on the results of a questionnaire survey of the population sample, it can be assumed that there is a connection between the peculiarities of the food pattern and vascular aging. Express assessment of eating behavior and calculation of vascular age can be used in outpatient practice for preventive counseling.

1. Бойцов С.А., Баланова Ю.А., Шальнова С.А. и др. Артериальная гипертония среди лиц 25-64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная терапия и профилактика. 2014; 13 (4): 4-14.

2. Чазова И.Е., Жернакова Ю.В. Рекомендации по диагностике и лечению артериальной гипертонии 2018 г. — слово за европейскими экспертами. Системные гипертензии. 2018; 15 (3): 6-10.

3. Nilsson PM, Boutouyrie P, Laurent S. Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension. 2009; 54 (1): 3-10.

4. Карпов Ю.А., Сорокин Е.В. Оценка риска осложнений при артериальной гипертонии и сосудистый возраст: новые инструменты для повышения качества лечения и улучшения взаимопонимания врача и больного. Атмосфера. Новости кардиологии. 2015; 2: 18-25.

5. Al-Solaiman Y, Jesri A, Zhao Y, et al. Low-Sodium DASH reduces oxidative stress and improves vascular function in salt-sensitive humans. J Hum Hypertens. 2009; 23(12): 826-835.

6. Schwingshackl L, Hoffmann G. Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis. 2014; 24(9): 929-939.

7. van de Laar RJJ, Stehouwer CDA, van Bussel BCT, et al. Adherence to a Mediterranean dietary pattern in early life is associated with lower arterial stiffness in adulthood: the Amsterdam Growth and Health Longitudinal Study. J Intern Med. 2013; 273 (1): 79-93.

8. Marin C, Yubero-Serrano EM, Lopez-Miranda J, et al. Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet. Int J Mol Sci. 2013; 14(5): 8869-8889.

9. Mozaffarian D, Appel LJ, Van Horn L. Components of a cardioprotective diet: new insights. Circulation. 2011; 123(24): 2870-2891.

10. Lin CL, Fang TC, Gueng MK. Vascular dilatory functions of ovo-lactovegetarians compared with omnivores. Atherosclerosis. 2001; 158(1): 247-251.

11. DeMarco VG, Habibi J, Jia G, et al. Low-dose mineralocorticoid receptor blockade prevents western diet-induced arterial stiffening in female mice. Hypertension. 2015; 66(1): 99-107.

12. Conlon MA, Bird AR. The impact of diet and lifestyle on gut microbiota and human health. Nutrients. 2014; 7(1): 17-44.

13. Орлов А.В., Ротарь О.П., Бояринова М.А. и др. Гендерные особенности распространенности поведенческих факторов риска у жителей Санкт-Петербурга. Вестник Российской академии медицинских наук. 2015; 70(5): 585-591.

14. Clinical guidelines «Arterial hypertension in adults». Moscow, 2020. URL: http://cr.rosminzdrav.ru/#!/schema/687 (дата обращения 18.04.2020).

15. Prieto-Merino D, Dobson J, Gupta AK, et al. ASCORE: an up-to-date cardiovascular risk score for hypertensive patients reflecting contemporary clinical practice developed using the (ASCOT-BPLA) trial data. J Hum Hypertens. 2013; 27(8): 492-496.

16. Diez-Fernandez A, Alvarez-Bueno C, Martinez-Vizcaino V, et al. Total dairy, cheese and milk intake and arterial stiffness: a systematic review and meta-analysis of cross-sectional studies. Nutrients. 2019; 29; 11(4): 741.

17. Moyama S, Minami K, Yano M, et al. Relationship between dietary patterns and brachial-ankle pulse wave velocity among middle-aged adults in Japan. Asia Pac J Clin Nutr. 2017; 26(3): 539-544.

18. Juraschek SP, Miller ER 3rd, Weaver CM, et al. Effects of Sodium reduction and the DASH diet in relation to baseline blood pressure. J Am Coll Cardiol. 2017; 70(23): 2841-2848.

19. Jennings A, Berendsen AM, de Groot LCPGM, et al. Mediterranean-style diet improves systolic blood pressure and arterial stiffness in older adults. Hypertension. 2019; 73(3): 578-586.

20. Klonizakis M, Alkhatib A, Middleton G, et al. Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity. Clin Sci (Lond). 2013; 124(9): 579-587.

21. Blanch N, Clifton PM, Keogh JB. A systematic review of vascular and endothelial function: effects of fruit, vegetable and potassium intake. Nutr Metab Cardiovasc Dis. 2015; 25(3): 253-266.