Preview

Трансляционная медицина

Расширенный поиск

Пропорциональная вспомогательная вентиляция

https://doi.org/10.18705/2311-4495-2020-7-1-39-52

Аннотация

Идея пропорциональной вспомогательной вентиляции легких, при которой респираторный паттерн — частоту и глубину дыхания — задает сам пациент, была высказана в 1992 году, однако до сих не нашла широкого практического применения. Одной из возможных причин тому является сложный алгоритм настройки режима на респираторах первых поколений. Со временем накопленный массив информации о раннем поражении диафрагмы в результате ее атрофии у пациентов, находящихся на респираторной поддержке, лег в основу осознания важности поддержания физиологического состояния диафрагмы во время искусственной вентиляции легких и обусловил появление термина «миотравма». На рубеже XXI века идея максимально возможного сохранения самостоятельного дыхания у пациента во время проведения механической вентиляции легких реализовалась в формировании концепции «диафрагма-протективной вентиляции». Стала очевидной необходимость дальнейшего развития технологий вспомогательной вентиляции легких, призванных уменьшить риск повреждения диафрагмы, снизить частоту асинхронии в паре «пациент–респиратор», облегчить процесс отлучения пациента от аппарата искусственной вентиляции легких. Настоящая статья, основанная на данных литературы и собственном клиническом опыте использования пропорциональной вентиляции, описывает особенности настройки режима на разных респираторах, расставляет акценты, необходимые для успешного клинического использования пропорциональной вентиляции легких. Описывает условия ее проведения, преимущества и ограничения.

Об авторе

В. А. Мазурок
Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации
Россия

Мазурок Вадим Альбертович, д.м.н., профессор, заведующий кафедрой анестезиологии и реаниматологии Института медицинского образования

ул. Аккуратова, д. 2, Санкт-Петербург, Россия, 197341



Список литературы

1. Маша и медведь / В обраб. М.А. Булатова. Мо- сква: Детгиз, 1960.

2. Schepens T, Dres M, Heunks L et al. Diaphragmprotective mechanical ventilation. Curr Opin Crit Care. 2019;25(1):77–85.

3. Decavèle M, Similowski T, Demoule A. Detection and management of dyspnea in mechanically ventilated patients. Curr Opin Crit Care. 2019;25(1):86–94.

4. Goligher EC, Dres M, Fan E et al. Mechanical ventilation-induced diaphragm atrophy strongly impacts clinical outcomes. Am J Respir Crit Care Med. 2018;197(2):204–213.

5. Demoule A, Jung B, Prodanovic H et al. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;188(2):213–219.

6. Younes M. Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Dis. 1992;145(1):114–120.

7. Georgopoulos D, Xirouchaki N, Tzanakis N et al. Data on respiratory variables in critically ill patients with acute respiratory failure placed on proportional assist ventilation with load adjustable gain factors (PAV+). Data Brief. 2016;8:484–493.

8. Georgopoulos D, Xirouchaki N, Tzanakis N et al. Driving pressure during assisted mechanical ventilation: Is it controlled by patient brain? Respir Physiol Neurobiol. 2016;228:69–75.

9. Vaporidi K, Psarologakis C, Proklou A et al. Driving pressure during proportional assist ventilation: an observational study. Ann Intensive Care. 2019;9(1):1.

10. Su PL, Kao PS, Lin WC et al. Limited predictability of maximal muscular pressure using the difference between peak airway pressure and positive end-expiratory pressure during proportional assist ventilation (PAV). Crit Care. 2016;20(1):382.

11. Alexopoulou C, Kondili E, Plataki M et al. Patientventilator synchrony and sleep quality with proportional assist and pressure support ventilation. Intensive Care Med. 2013;39(6):1040–1047.

12. Bosma KJ, Read BA, Bahrgard Nikoo MJ et al. A pilot randomized trial comparing weaning from mechanical ventilation on pressure support versus proportional assist ventilation. Crit Care Med. 2016;44(6):1098–1108.

13. Costa R, Spinazzola G, Cipriani F et al. A physiologic comparison of proportional assist ventilation with load-adjustable gain factors (PAV+) versus pressure support ventilation (PSV). Intensive Care Med. 2011;37(9):1494–1500.

14. Costa R, Navalesi P, Spinazzola G, et al. Comparative evaluation of different helmets on patient-ventilator interaction during noninvasive ventilation. Intensive Care Med. 2008; Intensive Care Med. 2008; 34(6):1102–1108.

15. Elganady AA, Beshey BN, Abdelasis AAH. Proportional assist ventilation versus pressure support ventilation in the weaning of patients with acute exacerbation of chronic obstructive pulmonary disease. Egypt J Chest Dis Tuberc. 2014;63(3):643–650.

16. Hergott CA, Bosma KJ, Ferreyra G et al. Effect of patient-ventilator asynchrony on arousals from sleep during pressure support and proportional assist mechanical ventilation. Chest. 2008;134: s18001–s18001.

17. Hosking B, Nikoo M, Bosma KJ. The incidence of patient-ventilator asynchrony during weaning from mechanical ventilation: a comparison of proportional assist ventilation (PAV) to pressure support (PS). Am J Respir Crit Care Med. 2011;183:A3197.

18. Schmidt M, Kindler F, Cecchini J et al. Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction. Crit Care. 2015;19:56.

19. Vasconcelos RS, Sales RP, Melo LHP et al. Influences of duration of inspiratory effort, respiratory mechanics, and ventilator type on asynchrony with pressure support and proportional assist ventilation. Respir Care. 2017;62(5):550–557.

20. Xirouchaki N, Kondili E, Vaporidi K et al. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med. 2008;34(11):2026–2034.

21. Younes M, Brochard L, Grasso S et al. A method for monitoring and improving patient: ventilator interaction. Intensive Care Med. 2007;33(8):1337–1146.

22. Iammes Y, Auran Y, Gouvernet J et al. The ventilatory pattern of conscious man according to age and morphology. Bull Eur Physiopathol Respir. 1979;15:527–540.

23. Marantz S, Patrick W, Webster K et al. Response of ventilator-dependent patients to different levels of proportional assist. J Appl Physiol. 1996:80(2):397–403.

24. Giannouli E, Webster K, Roberts D et al. Response of ventilator-dependent patients to different levels of pressure support and proportional assist. Am J Respir Crit Care Med. 1999;159(6):1716–1725.

25. Puddy A, Patrick W, Webster K et al. Respiratory control during volume-cycled ventilation in normal humans. J Appl Physiol. 1996;80(5):1749–1758.

26. Seymour CW, Pandharipande PP, Koestner T et al. Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med. 2012;40(10):2788–2796.

27. Lipshutz AK, Gropper MA. Acquired neuromuscular weakness and early mobilization in the intensive care unit. Anesthesiology. 2013;118(1):202–215.

28. Kallet RH, Campbell AR, Dicker RA et al. Effects of tidal volume on work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome. Crit Care Med. 2006;34(1):8–14.

29. Kallet RH, Corral W, Silverman HJ et al. Implementation of a low tidal volume ventilation protocol for patients with acute lung injury or acute respiratory distress syndrome. Respir Care. 2001;46(10):1024–1037.

30. Brander L, Sinderby C, Lecomte F et al. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury. Intensive Care Med. 2009;35(11):1979–1989.

31. Akoumianaki E, Prinianakis G1, Kondili E et al. Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients. Respir Physiol Neurobiol. 2014;203:82–89.

32. Kondili E, Prinianakis G, Alexopoulou C et al. Respiratory load compensation during mechanical ventilation-proportional assist ventilation with loadadjustable gain factors versus pressure support. Intensive Care Med. 2006;32(5):692–699.

33. Ruiz-Ferrón F, Machado J, Morante A et al. Respiratory work and pattern with different proportional assist ventilation levels. Med Intensiva. 2009;33(6):269–275.

34. Alexopoulou C, Kondili E, Vakouti E et al. Sleep during proportional-assist ventilation with load-adjustable gain factors in critically ill patients. Intensive Care Med. 2007;33(7):1139–1147.

35. Sinderby C, Beck J. Proportional assist ventilation and neurally adjusted ventilatory assist-better approaches to patient ventilator synchrony? Clin Chest Med. 2008;29(2):329–342.

36. Stein H, Firestone K, Rimensberger PC. Synchronized mechanical ventilation using electrical activity of the diaphragm in neonates. Clin Perinatol. 2012;39(3):525–542.

37. Colombo D, Cammarota G, Bergamaschi V et al. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute 2018.

38. Moerer O, Beck J, Brander L et al. Subjectventilator synchrony during neural versus pneumatically triggered non-invasive helmet ventilation. Intensive Care Med. 2008;34(9):1615–1623.

39. Beck J, Gottfried SB, Navalesi P et al. Electrical activity of the diaphragm during pressure support ventilation in acute respiratory failure. Am J Respir Crit Care Med. 2001;164(3):419–424.

40. Mitrouska J, Xirouchaki N, Patakas D et al. Effects of chemical feedback on respiratory motor and ventilatory output during different modes of assisted mechanical ventilation. Eur Respir J. 1999;13(4):873–882.

41. Nava S, Bruschi C, Fracchia C et al. Patientventilator interaction and inspiratory effort during pressure support ventilation in patients with different pathologies. Eur Respir J. 1997;10(1):177–183.

42. Beck J, Sinderby C, Lindström L et al. Diaphragm interference pattern EMG and compound muscle action potentials: effects of chest wall configuration. J Appl Physiol. 1997;82(2):520–530.

43. Sinderby CA, Beck JC, Lindström LH et al. Enhancement of signal quality in esophageal recordings of diaphragm EMG. J Appl Physiol. 1997;82(4):1370–1377.

44. Fabry B, Guttmann J, Eberhard L et al. An analysis of desynchronization between the spontaneously breathing patient and ventilator during inspiratory pressure support. Chest. 1995;107(5):1387–1394.

45. Sinderby C, Beck J, Spahija J et al. Voluntary activation of the human diaphragm in health and disease. J Appl Physiol. 1998;85(6):2146–2158.

46. Sinderby C, Beck J, Spahija J et al. Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects. Chest. 2007;131(3):711–717.

47. Sinderby C, Spahija J, Beck J et al. Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(7):1637–1641.


Рецензия

Для цитирования:


Мазурок В.А. Пропорциональная вспомогательная вентиляция. Трансляционная медицина. 2020;7(1):39-52. https://doi.org/10.18705/2311-4495-2020-7-1-39-52

For citation:


Mazurok V.A. Proportional assist ventilation. Translational Medicine. 2020;7(1):39-52. (In Russ.) https://doi.org/10.18705/2311-4495-2020-7-1-39-52

Просмотров: 1127


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2311-4495 (Print)
ISSN 2410-5155 (Online)