Possible Mechanisms for Normalization of the Level of Arterial Pressure with Unilateral Vasorenal Hypertension
https://doi.org/10.18705/2311-4495-2019-6-2-46-55
Abstract
The purpose of the study is on the model of vasorenal hypertension (2 kidney, 1 clamp) to study the dynamics of heart rate variability (HRV) spectrum components depending on stability of hypertension, developed after renal artery clamping. Experiments were put on Wistar male rats. During experiments in awake animals conducted registration systolic blood pressure (SBP), beat-to-beat interval (RR), spectral analysis of HRV. 1-3 weeks after the clipping of the renal artery, an elevation of MAP was observed in 21 of 33 rats. However, by week 8 of observations, the level of SBP was normalized in 11 animals. Analysis of the parameters studied in animals in which, after applying a clamp to the renal artery, an unstable elevation in the SBP was registered, showed a decrease in the high-frequency component (HF) of the HRV spectrum with an increase in the SBP. Normalization of SBP occurred within 1-5 weeks and was accompanied by restoration of HF and an increase in the length of RR. It was concluded that with unilateral ischemia of the kidneys, including mechanisms that positively affect the tone of the vagus, which counteracts the rise in blood pressure and promotes the normalization of its level, are activated.
About the Authors
M. G. Pliss
Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Pliss Mikhail G. - MD, PhD, Head of the Department for Experimental Physiology and Pharmacology, Almazov NMRC; Head of the Laboratory of Byophysics of Blood Circulation, Pavlov FSPSMU.
Saint Petersburg
Competing Interests:
No conflict of interest
N. V. Kuzmenko
Almazov National Medical Research Centre; Pavlov First Saint Petersburg State Medical University
Russian Federation
Competing Interests:
Russian Federation
Kuzmenko Nataliya V. - PhD, Senior Researcher of the Department for Experimental Physiology and Pharmacology, Almazov NMRC; Senior Researcher of the Laboratory of Byophysics of Blood Circulation, Pavlov FSPSMU.
Parkhomenko Str., 15 b, Saint Petersburg, 194156
Competing Interests:
No conflict of interest
V. A. Tsyrlin
Almazov National Medical Research Centre
Russian Federation
Competing Interests:
Russian Federation
Tsyrlin Vitaliy A. - MD, PhD, Dr. Sc., Professor, Leading Researcher of the Department of Experimental Physiology and Pharmacology, Almazov NMRC; Professor of the Department for Pharmacology, Pavlov FSPSMU.
Saint Petersburg
Competing Interests:
No conflict of interest
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Review
For citations:
Pliss M.G., Kuzmenko N.V., Tsyrlin V.A. Possible Mechanisms for Normalization of the Level of Arterial Pressure with Unilateral Vasorenal Hypertension. Translational Medicine. 2019;6(2):46-55. (In Russ.) https://doi.org/10.18705/2311-4495-2019-6-2-46-55
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