ACUTE TOXICITY, BIODISTRIBUTION, AND BIOELIMINATION OF ORGANOMODIFIED SILICA NANOPARTICLES WITH DIFFERENT GLOBULE SIZES
https://doi.org/10.18705/2311-4495-2014-0-3-88-95
Abstract
Organomodified silica (ORMOSIL) nanoparticles (NPs) are considered as promising nanocarriers for targeted drug and gene delivery. In the present study, we describe the process of synthesis of ORMOSIL NPs of different size (3 and 150 nm). The data showing the lack of systemic toxicity of ORMOSIL NPs after their intravenous administration are also presented. Investigation of ORMOSIL NP biodistribution and bioelimination demonstrated that these nanocarriers are not accumulated in the reticulo-endothelial system organs and are rapidly excreted from the organism through the kidney.
Keywords
наночастицы органомодифицированного кремнезема,
полиорганосилоксан,
острая токсичность,
биораспределение,
биодеградация,
направленная доставка лекарственных препаратов,
organomodified silica nanoparticles,
polyorganosiloxane,
acute toxicity,
biodistribution,
biodegradation,
targeted drug delivery
About the Authors
D. V. Korolev
Federal Almazov Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
V. N. Postnov
Federal Almazov Medical Research Centre; Saint-Petersburg State University
Russian Federation
Russian Federation
E. B. Naumysheva
Federal Almazov Medical Research Centre; Saint-Petersburg State University
Russian Federation
Russian Federation
I. S. Uskov
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
D. L. Sonin
Federal Almazov Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
M. M. Galagudza
Federal Almazov Medical Research Centre; First Pavlov State Medical University of St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Korolev D.V., Postnov V.N., Naumysheva E.B., Uskov I.S., Sonin D.L., Galagudza M.M. ACUTE TOXICITY, BIODISTRIBUTION, AND BIOELIMINATION OF ORGANOMODIFIED SILICA NANOPARTICLES WITH DIFFERENT GLOBULE SIZES. Translational Medicine. 2014;(3):88-95. (In Russ.) https://doi.org/10.18705/2311-4495-2014-0-3-88-95
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