ADIPONECTIN AS AN ENDOGENOUS REGULATOR OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS
https://doi.org/10.18705/2311-4495-2018-5-5-26-36
Abstract
Adiponectin is the most important adipokine controlling the food behavior and energy homeostasis. At present, there is much evidence that adiponectin also regulates the functions of the reproductive system, and its targets are hypothalamic neurons responsible for the synthesis and secretion of gonadoliberin, the pituitary gonadotrophs producing the luteinizing hormone, and the gonads. In the target tissues, which are blocks of the hypothalamic-pituitary-gonadal axis, all the main components of adiponectin-regulated signaling system, including adiponectin and both types of adiponectin receptors, are detected. The impairments in the adiponectin signaling pathways lead to the development of reproductive dysfunctions, as a result of which this pathways in the future can become one of the most important targets of therapy of diseases of the male and female reproductive systems. In the review, the current state of the problem of the participation of adiponectin in the functioning of the hypothalamic-pituitary-gonadal axis, and the relationship between the functional status of the reproductive system and the activity of the adiponectin system in hypothalamic neurons, gonadotrophs and gonads are considered.
About the Authors
J. R. Ryzhov
1.I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
2 Academician I.P. Pavlov First Saint Petersburg State Medical University, Saint Petersburg
Russian Federation
student
Russian Federation
student
A. O. Shpakov
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
Russian Federation
MD, PhD, Head of Laboratory of Molecular Endocrinology and Neurochemistry
Russian Federation
MD, PhD, Head of Laboratory of Molecular Endocrinology and Neurochemistry
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Review
For citations:
Ryzhov J.R., Shpakov A.O. ADIPONECTIN AS AN ENDOGENOUS REGULATOR OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS. Translational Medicine. 2018;5(5):26-36. (In Russ.) https://doi.org/10.18705/2311-4495-2018-5-5-26-36
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