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GENETICS OF SCHIZOPHRENIA AND BRAIN ASYMMETRY: IN THE SEARCHES OF MOLECULAR MARKERS

https://doi.org/10.18705/2311-4495-2014-0-3-44-56

Abstract

The review is devoted to the problem of schizophrenia genetics. The studies aimed at testing the most feasible hypotheses of a common genesis of schizophrenia and the lateralization in the human brain are considered. Particular attention is given to the searches of mutations in genes associated with functional and morphological asymmetry of the brain.

About the Authors

M. V. Zagrivnaja
Saint-Petersburg State University
Russian Federation


Y. B. Malashichev
Saint-Petersburg State University; Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Science
Russian Federation


References

1. Bleuler E. Dementia praecox oder Gruppe der Schizophrenien // Handbuch der Psychiatrie. Erstdruck. - Leipzig und Wien: F. Deuticke, 1911.

2. Schizophrenia // Concise Medical Dictionary. - Oxford University Press, 2010.

3. Краснова В.Н., Незнанова Н.Г., Семке В.Я., Тигранова А.С. Психиатрия: Национальное руководство / Ред. Т.Б. Дмитриева. - М.: ГЭОТАР-Медиа, 2009.

4. Freedman R. Schizophrenia // N. Engl. J. Med. - 2003. - Vol. 349, № 18. - P. 1738-1749.

5. Carmel M., Zarchi O., Michaelovsky E. et al. Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects // J. Psychiatr. Res. - 2014. - Vol. 56. - P. 28-35. / [Электронный ресурс]. doi: 10.1016/jjpsychires.2014.04.019

6. Nettle D., Clegg H. Schizotypy, creativity and mating success in humans // Proc. Biol. Sci. - 2006. - Vol. 273, № 1586. - P. 611-615.

7. Ogawa L.M., Vallender E.J. Evolutionary conservation in genes underlying human psychiatric disorders // Front Hum Neurosci. - 2014. - Vol. 8, art. 283. - P. 1-10. / [Электронный ресурс]. doi: 10.3389/fnhum.2014.00283

8. Agnatia L.F., Barlowb P., Ghidonic R. et al. Possible genetic and epigenetic links between human inner speech, schizophrenia and altruism // Brain Res. - 2012. Vol. 1476. - P. 38-57.

9. LeMay M. Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primate // Ann. N. Y Acad Sci. - 1976. - Vol. 280. - P. 349-366.

10. Galaburda A.M., LeMay M., Kemper T.L., Geschwind N. Right-left asymmetrics in the brain // Science. - 1978. - Vol. 199, № 4331. - P. 852-856.

11. Шульговский В.В. Основы нейрофизиологии. Учебное пособие. - М.: Аспект Пресс, 2000.

12. Хомская Е.Д. Нейропсихология: 4-е издание. - СПб.: Питер, 2005.

13. Hellige J.B., Longstreth L.E. Effects of concurrent hemisphere-specific activity on unimanual tapping rate // Neuropsychologia. - 1981. - Vol. 19, № 3. - P. 395-405.

14. Falk D. Interpreting sulci on hominin endocasts: old hypotheses and new findings // Front Hum. Neurosci. - 2014. - Vol. 8. - P. 134.

15. Анохин К.В. Психофизиология и молекулярная генетика мозга. Основы психофизиологии / Ред. Ю.И. Александров. - СПб., 2001.

16. Kennedy D.N., O’Craven K.M., Ticho B.S. et al. Structural and functional brain asymmetries in human situs inversus totalis // Neurology. - 1999. - Vol. 53. - P. 1260-1265.

17. Malashichev Y. Is there a link between visceral and neurobehavioral asymmetries in development and evolution? // Malashichev Y.B., Deckel A.W., (eds.). Behavioral and morphological asymmetries in vertebrates. - Georgetown: Landes Bioscience, 2006. - P. 33-44.

18. Crow T.J. Schizophrenia as failure of hemispheric dominance for language // Trends Neurosci. - 1997. - Vol. 20, № 8. - P. 339-343.

19. Horrobin D.F. Schizophrenia: the illness that made us human // Med. Hypotheses. - 1998. - Vol. 50, № 4. - P. 269-288.

20. Tamminga C.A., Holcomb H.H. Phenotype of schizophrenia: a review and formulation // Mol. Psychiatry. - 2005. - Vol. 10, № 1. - P. 27-39.

21. Riley B., Kendler K.S. Molecular genetic studies of schizophrenia // Eur. J. Hum. Genet. - 2006. - Vol. 14, № 6. - P. 669-680.

22. Ferris Jabr. No One Is Abandoning the DSM, but It Is Almost Time to Transform It // Scientific American (blogs). - 2013. - May 7. / [Электронный ресурс]. URL: http://blogs.scientificamerican.com/brainwaves/2013/05/07/no-one-is-rejecting-the-dsm-but-it-is-almost-time-to-transform-it (дата обращения - 20.07.2014).

23. Kupfer D. Responds to Criticism of DSM-5 by NIMH Director // Psychiatric news alert. - 2013. - May 6. / [Электронный ресурс]. URL: http://alert.psychiatricnews.org/2013/05/david-kupfer-md-responds-to-criticism.html (дата обращения - 20.07.2014).

24. Cannon T.D., Kaprio J., Lönnqvist J. et al. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study // Arch. Gen. Psychiatry. - 1998. - Vol. 55, № 1. - P. 67-74.

25. Sullivan P.F., Kendler K.S., Neale M.C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies // Arch. Gen. Psychiatry. - 2003. - Vol. 60, № 12. - P. 1187-1192.

26. Gogos J.A., Gerber D.J. Schizophrenia susceptibility genes: emergence of positional candidates and future directions // Trends Pharmacol. Sci. - 2006. - Vol. 27, № 4. - P. 226-233.

27. Nagai T., Ibi D., Yamada K. Animal model for schizophrenia that reflects gene-environment interactions // Biol. Pharm Bull. - 2011. - Vol. 34, № 9. - P. 1364-1368.

28. Иванов В.И., Ижевская В.Л. Геномика и этика // Геномика - медицине / Ред. В.И. Иванов, Л.Л. Киселёв. - М.: Академкнига, 2005. - С. 349-360.

29. Kobrynski L.J., Sullivan K.E. Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes // Lancet. - 2007. - Vol. 370, № 9596. - P. 1443-1452.

30. Paylor R., Glaser B., Mupo A., Ataliotis P. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome // Proc. Nat. Acad. Sci. USA. - 2006. - Vol. 103, № 20. - P. 7729-7734.

31. Shashi V., Keshavan M.S., Howard T.D. et al. Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome // Clin. Genet. - 2006. - Vol. 69, № 3. - P. 234-238.

32. St. Clair D., Blackwood D., Muir W. et al. Association within a family of a balanced autosomal translocation with major mental illness // Lancet. - 1990. - Vol. 336, № 8706. - P. 13-16.

33. Горбунова В.Н., Баранов В.С. Введение в молекулярную диагностику и генотерапию наследственных заболеваний. - СПб.: Специальная Литература, 1997. - 287 с.

34. Баранов В.С. Геномика на пути к предиктивной медицине // Acta Naturae. - 2009. - № 11-12.

35. Burmeister M., McInnis M.G., Zöllner S. Psychiatric genetics: progress amid controversy // Nat. Rev. Genet. - 2008. - Vol. 9, № 7. - P. 527-540.

36. Sullivan P.F., Lin D., Tzeng J.Y. et al. Genome-wide association for schizophrenia in the CATIE study: results of stage 1 // Mol. Psychiatry. - 2008. - Vol. 13, № 6. - P. 570-584.

37. Giusti-Rodriguez P., Sullivan P.F. The genomics of schizophrenia: update and implications // J. Clin. Invest. - 2013. - Vol. 123, № 11. - P. 4557-4563.

38. Schwab S.G., Wildenauer D.B. Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia // Eur Arch Psychiatry Clin Neurosci. - 2013. - Vol. 263, Suppl. 2. - S. 147-154. / [Электронный ресурс]. doi: 10.1007/s00406-013-0450-z

39. Голимбет В.Е., Корень Е.В. Вариации числа копий в геноме - новая страница в генетических исследованиях в области психиатрии: международный проект PsychCNVs // Журнал неврологии и психиатрии. - 2010. - № 1. - С. 107-109.

40. International Schizophrenia Consortium: Rare chromosomal deletions and duplications increase risk of schizophrenia // Nature. - 2008. - Vol. 455. - P. 237-241.

41. Walsh T., McClellan J.M., McCarthy S.E. et al. Rare structural variants disrupt multiple genes in neurodevelop-mental pathways in schizophrenia // Science. - 2008. - Vol. 320. - P. 539-543.

42. Xu B., Roos J.L., Levy S., van Rensburg E.J. et al. Strong association of de novo copy number mutations with sporadic schizophrenia // Nat. Genet. - 2008. - Vol. 40. - P. 880-885.

43. Cooper G.M., Coe B.P., Girirajan S. et al. A copy number variation morbidity map of developmental delay // Nat. Genet. - 2011. - Vol. 43. - P. 838-846.

44. Pinto D., Pagnamenta A.T., Klei L. et al. Functional impact of global rare copy number variation in autism spectrum disorders // Nature. - 2010. - Vol. 466. - P. 368-372.

45. Burbach J.P., van der Zwaag B. Contact in the genetics of autism and schizophrenia // Trends Neurosci. - 2009. - Vol. 32, № 2. - P. 69-72.

46. Karayiorgou M., Morris M.A., Morrow B. et al. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11 // Proc. Nat. Acad. Sci. USA. - 1995. - Vol. 92. - P. 7612-7616.

47. Driscoll D.A., Salvin J., Sellinger B. et al. Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: implications for genetic counselling and prenatal diagnosis // J. Med. Genet. - 1993. - Vol. 30. - P. 813-817.

48. Shprintzen R., Goldberg R., Lewin M. et al. A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome // Cleft Palate J. - 1978. - Vol. 15. - P. 56-62.

49. Rees E., Walters J.T., Georgieva L. et al. Analysis of copy number variations at 15 schizophrenia-associated loci // Br. J. Psychiatry. - 2014. - Vol. 204, № 2. - P. 108-114.

50. Ingason A., Kirov G., Giegling I. et al. Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness // Am. J. Psychiatry. - 2011. - Vol. 168, № 4. - P. 408-417.

51. Malhotra D., Sebat J. CNVs: harbingers of a rare variant revolution in psychiatric genetics // Cell. - 2012. - Vol. 148. - P. 1223-1241.

52. Marian A.J. Molecular Genetic Studies of Complex Phenotypes // Transl. Res. - 2012. - Vol. 159, № 2. - P. 64-79.

53. Thusberg J., Olatubosun A., Vihinen M. Performance of mutation pathogenicity prediction methods on missense variants // Hum. Mutat. - 2011. - Vol. 32, № 4. - P. 358-368.

54. Hu C.Y., Qian Z.Z., Lu S.S. et al. Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar disorder: an updated metaanalysis // J. Neural Transm. - 2014. - Jun 18. [Epub ahead of print].

55. Francks C., Maegawa S., Laurén J., Abrahams B.S. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia // Mol. Psychiatry. - 2007. - Vol. 12, № 12. - P. 1129-1139.

56. Francks C., Fisher S.E., MacPhie I.L. et al. A genome-wide linkage screen for relative hand skill in sibling pairs // Am. J. Hum. Genet. - 2002. - Vol. 70, № 3. - P. 800-805.

57. Francks C., DeLisi L.E., Shaw S.H. et al. Parent-of-origin effects on handedness and schizophrenia susceptibility on chromosome 2p12-q11 // Hum. Mol. Genet. - 2003. - Vol. 12, № 24. - P. 3225-3230.

58. Levchenko A., Davtian S., Petrova N., Malashichev Y. Sequencing of five left-right cerebral asymmetry genes in a cohort of schizophrenia and schizotypal disorder patients from Russia // Psychiatr. Genet. - 2014. - Vol. 24, № 2. - P. 75-80.

59. Purcell S.M., Moran J.L., Fromer M., Ruderfer D. A polygenic burden of rare disruptive mutations in schizophrenia // Nature. - 2014. - Vol. 506, № 7487. - P. 185-190.

60. Claridge G., Pryor R., Watkins G. Sounds from the bell jar: ten psychotic authors. - London: The Macmollan Press Ltd., 1990.

61. Crespi B., Summers K. Adaptive evolution of genes underlying schizophrenia // Proc. R. Soc. B. - 2007. - Vol. 274. - P. 2801-2810.

62. Tsang S.Y., Zhong S., Mei L. et al. Social Cognitive Role of Schizophrenia Candidate Gene GABRB2 // PLoS One. - 2013. - Vol. 8, № 4. - e62322. / [Электронный ресурс]. doi: 10.1371/journal.pone.0062322

63. Torri F., Akelai A., Amann-Zalcenstein D. et al. Fine mapping of AHI1 as a schizophrenia susceptibility gene: from association to evolutionary evidence // FASEB J. - 2010. - Vol. 24, № 8. - P. 3066-3082.

64. Ingason A., Giegling I., Cichon S. et al. A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia // Hum. Mol. Genet. - 2010. - Vol. 19, № 7. - P. 1379-1386.

65. Alary M., Delcroix N., Leroux E. et al. Functional hemispheric lateralization for language in patients with schizophrenia // Schizophr. Res. - 2013. - Vol. 149, № 1-3. - P. 42-47.

66. Is schizophrenia the price that Homo sapiens pays for language? // Schizophr. Res. - 1997. - Vol. 28, № 2-3. - P. 127-141.

67. Falk D. Interpreting sulci on hominin endocasts: old hypotheses and new findings // Front. Hum. Neurosci. - 2014. - Vol. 8. - P. 134.

68. Crow T.J. A Darwinian approach to the origins of psychosis // Br. J. Psychiatry. - 1995. - Vol. 167. - P. 12-25.

69. Bradley S. Folley and Sohee Park Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: A behavioral and near-infrared optical imaging study // Schizophr. Res. - 2005. - Vol. 80, № 2-3. - P. 271-282.

70. Burdick K.E., Lencz T., Funke B. et al. Genetic variation in DTNBP1 influences general cognitive ability // Hum. Mol. Genet. - 2006. - Vol. 15. - P. 1563-1568.

71. Karlsson J.L. Mental abilities of male relatives of psychotic patients // Acta Psychiatr. Scand. - 2001. - Vol. 104. - P. 466-468.

72. Marchant L.F., McGrew W.C. Human handedness: an ethological perspective // Hum. Evol. - 1998. - Vol. 13, № 3-4. - P. 221-228.

73. Frayer D.W., Lozano M., de Castro J.M.B. et al. More than 500.000 years of right-handedness in Europe // Laterality. - 2012. - Vol. 17. - P. 51-69.

74. Uomini N.T. The prehistory of handedness: archaeological data and comparative ethology // J. Hum. Evol. - 2009. - Vol. 57. - P. 411-419.

75. Lehman R.A.W. Manual Preference in Prosimians, Monkeys and Apes // Primate Laterality : Current Behavioural Evidence of Primate Asymmetries / J.P. Ward and W.D. Hopkins (eds.). - Berlin-Heidelberg-New York, SpringerVerlag, 1993. - Ch. 6. - P. 149-181.

76. Hopkins W.D. Comparative and familial analysis of handedness in great apes // Psychol. Bull. - 2006. - Vol. 132. - P. 538-559.

77. Hopkins W.D., Stoinski T.S., Lukas K.E. et al. Comparative assessment of handedness for a coordinated bimanual task in chimpanzees (Pan troglodytes), gorillas (Gorilla gorilla), and orangutans (Pongo pygmaeus) // J. Comp. Psychol. - 2003. - Vol. 117. - P. 302-308.

78. Hopkins W.D. Posture and reaching in chimpanzees (Pan troglodytes) and orangutans (Pongo pygmaeus) // J. Comp. Psychol. - 1993. - Vol. 17. - P. 162-168.

79. Corbetta D. Right-handedness may have come first: Evidence from studies in human infants and nonhuman primates // Behav. Brain Sci. - 2003. - Vol. 26. - P. 217-218.

80. Shafer D.D. Patterns of Handedness: Comparative Study of Nursery School Children and Captive Gorillas // Primate Laterality: Current Behavioural Evidence of Primate Asymmetries / J.P. Ward and W.D. Hopkins (eds.). - Berlin-Heidelberg-New York, Springer-Verlag, 1993. - Chapter 12. - P. 267-283.

81. GiljovA., Karenina K., Malashichev Y. Limb preferences in a marsupial, Macropus rufogriseus: evidence for postural effect // Anim. Behav. - 2012a. - Vol. 83. - P. 525-534.

82. Giljov A., Karenina K., Malashichev Y. Does Bipedality Predict the Group-Level Manual Laterality in Mammals? // PLoS ONE. - 2012b. - Vol. 7, № 12. / [Электронный ресурс]. e51583. doi: 10.1371/journal.pone.0051583e51583

83. Amunts K., Schlaug G., Schleicher A. et al. Asymmetry in the human motor cortex and handedness // Neuroimage. - 1996. - Vol. 4. - P. 216-222.

84. Knecht S., Drager B., Deppe M. et al. Handedness and hemispheric language dominance in healthy humans // Brain. - 2000. - Vol. 123. - P. 2512-2518.

85. Corballis M.C. From mouth to hand: gesture, speech, and the evolution of right-handedness // Behav. Brain Sci. - 2003. - Vol. 26. - P. 199-208, discussion - Р. 208-260.

86. Uomini N.T., Meyer G.F. Shared Brain Lateralization Patterns in Language and Acheulean Stone Tool Production: A Functional Transcranial Doppler Ultrasound Study // PLoS ONE. - 2013. - Vol. 8, № 8. / [Электронный ресурс]. doi: 10.1371/journal.pone.0072693

87. Shapleske J., Rossell S.L., Woodruff P. W., David A.S. The planum temporale: a systematic, quantitative review of its structural, functional and clinical significance // Brain Res. Rev. - 1999. - Vol. 29. - P. 26-49.

88. Matheny A.P. Hereditary determinants of manual torque // Jr. Percept. Mot. Skills. - 1979. - Vol. 49, № 3. - P. 751-755.

89. Hopkins W.D., Adams M.J., Weiss A. Genetic and environmental contributions to the expression of handedness in chimpanzees (Pan troglodytes) // Genes Brain Behav. - 2013. - Vol. 12. - P. 446-452.

90. Eriksson N., Macpherson J.M., Tung J.Y. et al. Web-based, participant-driven studies yield novel genetic associations for common traits // PLoS Genet. - 2010. Vol. 6. - P. 1-20.

91. McManus I.C. Right Hand, Left Hand. - London: Orion Books Ltd, 2002.

92. McManus C., Davison A., Armour J.A.L. Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies // I. Ann. N.Y. Acad. Sci. - 2013. - Vol. 1288. - P. 48-58.

93. Van Agtmael T., Forrest S.M., Williamson R. Parametric and non-parametric linkage analysis of several candidate regions for genes for human handedness // Eur. J. Hum. Genet. - 2002. - Vol. 10. - P. 623-630.

94. Van Agtmael T., Forrest S.M., Del-Favero J. et al. Parametric and nonparametric genome scan analyses for human handedness // Eur. J. Hum. Genet. - 2003. - Vol. 11. - P. 779-783.

95. Savitz J., van der Merwe L., Solms M., Ramesar R. Lateralization of hand skillin bipolar affective disorder // Genes Brain Behav. - 2007. - Vol. 6. - P. 698-705.

96. Brandler W.M., Morris A.P., Evans D.M. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill // PLoS Genet. - 2013. - Vol. 9, № 9.- e1003751. / [Электронный ресурс]. doi: 10.1371/journal.pgen.1003751

97. Satz P., Nelson L., Green M. Ambiguous-handedness: incidence in a nonclinical sample // Neuropsychologia. - 1989. - Vol. 27. - P. 1309-1310.

98. Sommer I., Ramsey N., Kahn R. et al. Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis // Br. J. Psychiatry. - 2001. - Vol. 178. - P. 344-351.

99. Dragovic M., Hammond G. Handedness in schizophrenia: a quantitative review of evidence // Acta Psychiatr. Scand. - 2005. - Vol. 111. - P. 410-419.

100. Deep-Soboslay A., Hyde T.M., Callicott J.P. et al. Handedness, heritability, neurocognition and brain asymmetry in schizophrenia // Brain. - 2010. - Vol. 133. - P. 3113-3122.

101. Narr K.L., Bilder R.M., Luders E. et al. Asymmetries of cortical shape: Effects of handedness, sex and schizophrenia // Neuroimage. - 2007. - Vol. 34. - P. 939-948.

102. Mazoyer B., Zago L., Jobard G. et al. Gaussian mixture modeling of hemispheric lateralization for language in a large sample of healthy individuals balanced for handedness // PLoS One. - 2014. - Vol. 9, № 6. - e101165. / [Электронный ресурс]. doi: 10.1371/journal. pone.0101165

103. Tanaka S., Kanzaki R., Yoshibayashi M. et al. Dichotic listening in patients with situs inversus: brain asymmetry and situs asymmetry // Neuropsychologia. - 1999. - Vol. 37, № 7. - P. 869-874.

104. Tubbs R.S., Wellons J.C., Salter G. et al. Intracranial anatomic asymmetry in situs inversus totalis // Anat. Embryol. - 2003. - Vol. 206. - P. 199-202.

105. Malashichev Y.B., Wassersug R.J. Left and right in the amphibian world: which way to develop and where to turn? // Bioessays. - 2004. - Vol. 26, № 5. - P. 512-522.

106. Barth K.A., Miklosi A., Watkins J. et al. Fsi zebra fish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses // Current Biology. - 2005. - Vol. 15. - P. 844-850.

107. Blackiston D.J., Levin M. Inversion of left-right asymmetry alters performance of Xenopus tadpoles in nnlateralized cognitive tasks. // Anim. Behav. - 2013. - Vol. 86. - P. 459-466.

108. Bleich-Cohen M., Sharon H., Weizman R. et al. Diminished language lateralization in schizophrenia corresponds to impaired inter-hemispheric functional connectivity // Schizophr Res. - 2012. - Vol. 134, № 2-3. P. 131-136.

109. Crow T.J. Schizophrenia as failure of hemispheric dominance for language // Trends Neurosci. - 1997. - Vol. 20, № 8. - P. 339-343.

110. Petty R.G. Structural asymmetries of the human brain and their disturbance in schizophrenia // Schizophr Bull. - 1999. - Vol. 25, № 1. - P. 121-139.

111. Rapoport J.L., Addington A.M., Frangou S. The neurodevelopmental model of schizophrenia: update 2005 // Mol. Psychiatry. - 2005. - Vol. 10. - P. 434-449.

112. DeLisi L.E., Sakuma M., Kushner M. et al. Anomalous cerebral asymmetry and language processing in schizophrenia // Schizophr Bull. - 1997. - Vol. 23, № 2. - P. 255-271.

113. Berlim M.T., Mattevi B.S., Belmonte-de-Abreu P., Crow T.J. The etiology of schizophrenia and the origin of language: overview of a theory // Compr. Psychiatry. - 2003. - Vol. 44, № 1. - P. 7-14.


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Zagrivnaja M.V., Malashichev Y.B. GENETICS OF SCHIZOPHRENIA AND BRAIN ASYMMETRY: IN THE SEARCHES OF MOLECULAR MARKERS. Translational Medicine. 2014;(3):44-56. (In Russ.) https://doi.org/10.18705/2311-4495-2014-0-3-44-56

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