ROLE OF MONOGENIC DIABETES IN STRUCTURE OF DIABETES MELLITUS IN CHILDREN: DIAGNOSTICS AND GENETIC PROGNOSIS
https://doi.org/10.18705/2311-4495-2014-0-3-16-22
Abstract
Monogenic diabetes includes neonatal diabetes and MODY. Often monogenic diabetes initially can be diagnosed as type 1 or type 2 diabetes. However, making of the correct diagnosis is required for changing of therapy and genetic counseling of family members. In this article the own clinical observations of two families with MODY 3 are presented. Confirmation of genetic mutation in HNF-1a gene leads to early diagnostics of diabetes and prevention of microvascular complications in some family members and explanation of some associated clinical features in this patients.
Keywords
моногенный диабет,
MODY,
неонатальный диабет,
дети,
monogenic diabetes,
MODY,
neonatal diabetes,
children
About the Authors
I. L. Nikitina
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
I. Yu. Artemieva
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
T. A. Khodyuchenko
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
E. S. Vasichkina
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
A. A. Kostareva
Federal Almazov Medical Research Centre
Russian Federation
Russian Federation
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Review
For citations:
Nikitina I.L., Artemieva I.Yu., Khodyuchenko T.A., Vasichkina E.S., Kostareva A.A. ROLE OF MONOGENIC DIABETES IN STRUCTURE OF DIABETES MELLITUS IN CHILDREN: DIAGNOSTICS AND GENETIC PROGNOSIS. Translational Medicine. 2014;(3):16-22. (In Russ.) https://doi.org/10.18705/2311-4495-2014-0-3-16-22
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