CLINICO-FUNCTIONAL EVALUATION OF TENSION ADAPTATION IN YONG MEN WITH MILD HYPERTENSI ON ACCORDING TO BLOOD LEUKOCYTE
https://doi.org/10.18705/2311-4495-2016-3-5-6-12
Abstract
Objective. To investigate the clinical significance of estimation of adaptive reaction using L.Gharkavi algorithm in young people with borderline or mild arterial hypertension (AH).
Design and methods. 53 adolescents (16-26 yrs, mean 19.3+/-0.4 yrs) with normal body mass index (BMI; 18.5 — 24.9 kg/m2) were included. Antropometrics and laboratory measurements of the participants were recorded. Heart rate variability in frequency domain has been obtained from 24-h polyfunctional outpatient Holter monitoring (ECG+BP+chestpletysmography; Incart, SPb, Russia).
Results. All types of adaptive reaction were randomly met in the study population except «stress reaction». 13 adolescents (24.5%) had a leukocyte distribution corresponding to «training reaction». 26.4% young men demonstrated «reaction of quiet activation», 28,3% — «reaction of increased activation» and 20,8% of adolescents had «hyper activation». Mean systolic BP in this group at night (124.0±3.6 mm Hg) was higher than in «hyper activation» group (116.8±2.2 mm Hg, P<0.05). Diastolic BP in «training group» in the awakening time was higher than in «hyper activation» group (76.0±2.0 vs 70.6±2.2 mm Hg, P=0,04). Night BP decline for DBP in «training» and «hyper activation» groups was 20,1% to be due to a tendency to excessive night decrease of DBP («over-dippers»). Adolescents with «training» reaction had higher power of LF band at night than in «quiet activation» group (P=0,04) and «hyper activation» ones (P=0,05). Direct significant correlation exist between VFL power in the day-time and tension of leukocytes count registered if its value is out normal range (r=0,357).
Conclusion. Clinical assessment of leukocyte percentage types may be informative in young men with mild AH.
About the Authors
E. N. Kazidaeva
Medical Institute, Tula State University
Russian Federation
Russian Federation
MD, PhD, and Associate Professor at the Department of Internal Diseases Propedeutics
Lenina pr., 92, Tula, Russia, 300012
Yu. L. Venevtseva
Medical Institute, Tula State University
Russian Federation
Russian Federation
professor, MD, Head of Propedeutics of Internal Diseases Department
A. H. Melniкov
Medical Institute, Tula State University
Russian Federation
Russian Federation
professor, MD, Propedeutics of Internal Diseases Department
References
1. Kislyak O A, Storozhakov GI, Petrova EV et al. Risk factors for cardiovascular disease in adolescents with hypertension. Pediatrics=Pediatriya. 2003; 2: 16-20. In Russian. [Кисляк О .А., Сторожаков Г .И., Петрова Е.В. и др. Факторы риска сердечно-сосудистых заболеваний у подростков с артериальной гипертензией. Педиатрия. 2003; 2: 16-20].
2. Dickinson CJ. T he determinants of long-term blood pressure stability: control of trough blood pressure during sleep. J Hypertens. 1998;16(7):907-912.
3. Zemtsovsky EV. Sports cardiology. SPb.: Hippocrates, 1995. p. 448. In Russian. [Земцовский Э.В. Спортивная кардиология. СПб.: Г иппократ, 1995. с. 448].
4. Baevsky RM, Ivanov GG. Heart rate variability: theoretical aspects and clinical applications. M.: Medicine,2000. p. 295. In Russian. [Баевский Р .М., И ванов Г .Г. Вариабельность сердечного ритма: теоретические аспекты и возможности клинического применения. М.: Медицина, 2000. с. 295].
5. Garkavi LH, Kvakina EB, U kolova MA. Adaptive response and resistance of the organism, 3rd edition enlarged. Rostov-on-Don, 1990. p. 224. In Russian. [Гаркави Л .Х., Квакина Е.Б., У колова М.А. А даптационные реакции и резистентность организма, 3-е издание дополненное. Ростов-на-Дону, 1990. с. 224].
6. Novikov DK, Novikova VI. Evaluation of the immune status. Moscow-Vitebsk, 1996. p. 281. In Russian. [Новиков Д .К., Новикова В.И. О ценка иммунного статуса. Москва- Витебск, 1996. с. 281].
7. Averkina NA, Filatova EG. Psychological factors in chronic pain. Journal of Neurology and Psychiatry= Zhurnal nevrologii i psihiatrii. 2000; 12: 21-27. In Russian. [Аверкина Н. А ., Филатова Е. Г . Психологические факторы при хронической боли. Журнал неврологии и психиатрии. 2000: 12; 21-27].
8. Derkach ZV. Adaptation processes in chronic renal disease. Bulletin of the Russian Military Medical Academy. 2013; 2 (42): 40-43. In Russian. [Деркач З .В. Адаптационные процессы при хронической болезни почек. Вестник Р оссийской военно-медицинской академии. 2013; 2 (42): 40-43].
9. Nikolaev NV, Bolotovа NV, Kirichuk VF et al. Study of adaptive mechanisms and correction of disorders in children and adolescents with diabetes mellitus type 1. Pediatrics=Pediatriya. 2009; 88(6): 23-26. In Russian. [Николаева Н.В., Болотова Н.В., Киричук В.Ф. и др. Изучение адаптационных механизмов и коррекция их нарушений у детей и подростков с сахарным диабетом 1-го типа. Педиатрия. 2009; 88(6): 23-26].
10. Brazhenko NA, Brazhenko O N, T rofimov VI. Аdaptive reactions and ways to improve the effectiveness of treatment in modern conditions. New St. Petersburg medical statements. 2002; 2: 49-53. In Russian. [Браженко Н. А ., Браженко О . Н., Т рофимов В. И . А даптационные реакции организма и пути повышения эффективности лечения в современных условиях. Новые Санкт-Петербургские врачебные ведомости. 2002; 2: 49-53].
11. Vaduganathan M, Ambrosy AP, Greene SJ, Mentz RJ, Subacius HP, Maggioni AP, Swedberg K, Nodari S, Zannad F, Konstam MA, Butler J, Gheorghiade M; EVEREST trial investigators. Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial. Circ Heart Fail. 2012; 5(6):750-758.
12. Melnikov AH, Venevtseva YuL, Korneeva LN. Heart rate variability in the assessment of the level of adaptation in young adults. Arrhythmology Bulletin=Vestnik Aritmologii. 2000; 16: 53-55. In Russian. [Мельников А.Х., Веневцева Ю.Л., Корнеева Л .Н. Показатели вариабельности ритма сердца в оценке уровня адаптации лиц молодого возраста. Вестник аритмологии. 2000; 16: 53-55].
13. Prevention, diagnostics and management of arterial hypertension. Russian guidelines (3d reappraisal) by Expert Committee of All-Russian Research Cardiology Society. Cardiovascular T herapy and Prevention- =Kardiovaskulyarnaya T erapiya i Profilaktika. 2008; 7 (6) suppl. 2: 3-30. In Russian. [Профилактика, диагностика и лечение артериальной гипертензии. Р оссийские рекомендации (третий пересмотр), разработаны комитетом экспертов ВНОК. Кардиоваск. терапия и профилактика. 2008; 7 (6) Прил. 2: 3-30].
14. Maisel AS, Knowlton KU, Fowler P, et al. Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. Journal of Clinical Investigation. 1990; 85(2): 462-467.
15. Thomson SP, McMahon LJ, Nugent CA. Endogenous cortisol: a regulator of the number of lymphocytes in peripheral blood. Clin Immunol Immunopathol. 1980; 17(4): 506-514.
Review
For citations:
Kazidaeva E.N., Venevtseva Yu.L., Melniкov A.H. CLINICO-FUNCTIONAL EVALUATION OF TENSION ADAPTATION IN YONG MEN WITH MILD HYPERTENSI ON ACCORDING TO BLOOD LEUKOCYTE. Translational Medicine. 2016;3(5):6-12. (In Russ.) https://doi.org/10.18705/2311-4495-2016-3-5-6-12
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