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Ventricular arrhythmias of the recovery period after physical exercise: analysis of the problem

https://doi.org/10.18705/2311-4495-2025-12-4-330-339

EDN: MIKXQE

Abstract

Traditionally, stress tests in medicine have been used to diagnose coronary artery disease. However, this article explores their potential far more broadly, demonstrating that these tests can provide crucial information in the evaluation of patients with ventricular arrhythmias. The paper offers a detailed examination of the pathophysiological mechanisms underlying these arrhythmias, identifying autonomic nervous system imbalance as a key factor — specifically, reduced vagal reactivity against a backdrop of persistent elevated sympathetic activity.
The significance of a thorough assessment is emphasized, extending beyond the exercise phase itself to include the recovery period, which is usefully divided into an early phase (up to three minutes) and a late phase (after four minutes). A minute-by-minute analysis of ventricular arrhythmias recorded during post-exercise recovery enables the identification of specific early recovery phase arrhythmias (termed “sympathetic-driven”), which carry an unfavorable prognosis. These arrhythmias prove to be more significant predictors of cardiovascular complications than those occurring solely at peak exercise and often serve as markers of concealed structural heart disease.
The article underscores that the primary objective for the clinician must be the timely identification of the underlying pathology manifesting as these arrhythmias. Differentiated approaches to antiarrhythmic treatment, tailored to the nature of the rhythm disturbances, are also discussed. The early detection of patients with such arrhythmias will help prevent cases of sudden cardiac death, particularly among young individuals engaged in sports. Thus, the presented research highlights the pressing need for further in-depth study and systematization of ventricular arrhythmias during the recovery period to enhance the effectiveness of diagnostics and prevention in cardiovascular disease.

About the Authors

E. S. Zhabina
Almazov National Medical Research Centre
Russian Federation

Ekaterina S. Zhabina, MD, PhD, Senior researcher of the research laboratory of electrocardiology, assistant professor of faculty therapy with clinic of the Institute of Medical Education

Akkuratova str., 2, Saint Petersburg, 197341 


Competing Interests:

The authors declare no conflict of interest.



A. S. Volodkin
Almazov National Medical Research Centre
Russian Federation

Alexey S. Volodkin, 6th year student of the Faculty of Medicine of the Institute of Medical Education

Saint Petersburg 


Competing Interests:

The authors declare no conflict of interest.



T. V. Treshkur
Almazov National Medical Research Centre
Russian Federation

Tatyana V. Treshkur, MD, PhD, Associate professor, Head of the research laboratory of electrocardiology

Saint Petersburg 


Competing Interests:

The authors declare no conflict of interest.



References

1. Kushakovsky MS. Cardiac arrhythmias (Heart rhythm disorders and conduction disorders: causes, mechanisms, electrocardiographic and electrophysiological diagnostics, clinical features, and treatment). A guide for physicians. 4rd ed. SPb.: Foliant; 2014. 720 p. (In Russ.)

2. Zhabina ES, Tulintseva TE, Ryngach EA, et al. Ventricular arrhythmias induced by exercise. Journal of Arrhythmology. 2017;87: 49–54. (In Russ.)

3. Pedersen CT, Kay GN, Kalman J, et al. EHRA/ HRS/APHRS expert consensus on ventricular arrhythmias. Heart Rhythm. 2014;11(10):166–196.

4. Kafka W, Petri H, Rudolph W. Exercise testing in the assessment of ventricular arrhythmias. Herz. 1982;7(3):140–149.

5. Zipes DP, Camm AJ, Borggrefe M, et al. ACC/ AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines. J Am Coll Cardiol. 2006;48(5):247–346.

6. Marijon E, Taf M, Celermajer DS, et al. Sports-related sudden death in the general population. Circulation. 2011;124:672–681.

7. Heidbuchel H, Willems R, Jordaens L, et al. Intensive recreational athletes in the prospective multinational ICD sports safety registry: results from the European cohort. Eur J Prev Cardiol. 2019;26:764–775. https://doi.org/10.1177/2047487319834852

8. Lee V, Perera D, Lambiase P. Prognostic significance of exercise-induced premature ventricular complexes: a systematic review and meta-analysis of observational studies. Heart Asia. 2017;9:14–24. https://doi.org/10.1136/heartasia-2016-010854

9. Frigy A, Csiki E, Caraşca C, et al. Autonomic influences related to frequent ventricular premature beats in patients without structural heart disease. Medicine. 2018;97(28):e11489. https://doi.org/10.1097/MD.0000000000011489

10. Shishko VI. Autonomic regulation of cardiac activity. Journal of GrSMU. 2009;3:6–8. (In Russ.)

11. Capilupi MJ, Kerath SM, Becker LB. Vagus nerve stimulation and the Cardiovascular System. Cold Spring Harb Perspect Med. 2020;10(2):034173. https://doi.org/10.1101/cshperspect.a034173

12. Ng GA. Vagal modulation of cardiac ventricular arrhythmia. Journal of Experimental Physiology. 2014; 99(2):295–299.

13. Brack KE, Patel VH, Coote JH, et al. Nitric oxide mediates the vagal protective effect on ventricular fibrillation via effects on action potential duration restitution in the rabbit heart. J Physiol. 2007; 583(2): 695–704. https://doi.org/10.1113/jphysiol.2007.138461

14. Kapplinger J, Landstrom A, Salisbusy B, et al. Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associated mutations from background genetic noise. J Am Coll Cardiol. 2011;57(23):2317–2327.

15. Dzikowicz DJ, Carey MG. Exercise-induced premature ventricular contractions are associated with myocardial ischemia among asymptomatic adult male firefighters: implications for enhanced risk stratification. Biol Res Nurs. 2020;22(3):369– 377. https://doi.org/10.1177/1099800420921944

16. Frolkis J, Pothier C, Blackstone E, et al. Frequent ventricular ectopy after exercise as a predictor of death. N Engl J Med. 2003;348:781–790.

17. Einbrodt P. P. Über herzreizung und ihr verhältniss zum blutdruck. Sitzungsber Akad Wiss Wien. 1860;38:345– 359. Einbrodt PP. On heart irritation and its relation to blood pressure. Sitzungsber Akad Wiss Wien. 1860;38:345–359. (In Germ.)

18. Huang J, Qian J, Yao W, et al. Vagus nerve stimulation reverses ventricular electrophysiological changes induced by hypersympathetic nerve activity. Exp Physiol. 2015;100(3):239–248. https://doi.org/10.1113/expphysiol.2014.082842

19. Liu C, Jiang H, Yu L, et al. Vagal stimulation and arrhythmias. J Atr Fibrillation. 2020;13(1):2398. https://doi.org/10.4022/jafib.2398

20. Qiu S, Cai X, Sun Z, et al. Heart rate recovery and risk of cardiovascular events and all-cause mortality: a meta-analysis of prospective cohort studies. J Am Heart Assoc. 2017;6(5):e005505. https://doi.org/10.1161/JAHA.117.005505

21. Imai K, Sato H, Hori M, et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol. 1994;24(6):1529–1535. https://doi.org/10.1016/0735-1097(94)90150-3

22. Zhabina ES, Ivanova TE, Treshkur TV. Improving an automatic stress test analysis protocol as a problem solution for sympatho-dependent arrhythmias identification. Russian Journal of Preventive Medicine. 2024;27(11):115–121. (In Russ.)

23. Refaat MM, Gharios C, Moorthy MV, et al. Exerciseinduced ventricular ectopy and cardiovascular mortality in asymptomatic individuals. J Am Coll Cardiol. 2021;78(23): 2267–2277. https://doi.org/10.1016/j.jacc.2021.09.1366

24. Dewey FE, Kapoor JR, Williams RS, et al. Ventricular arrhythmias during clinical treadmill testing and prognosis. Arch Intern Med. 2008;168(2):225–234. https://doi.org/10.1001/archinte.168.2.225

25. Partington S, Myers J, Cho S, et al. Prevalence and prognostic value of exercise-induced ventricular arrhythmias. Am Heart J. 2003;145(1):139–146. https://doi.org/10.1067/mhj.2003.60

26. Faris J, McHenry P, Jordan J. Prevalence and reproducibility of exercise-induced ventricular arrhythmias during maximal exercise testing in normal men. Am J Cardiol. 1976;37:617–622. https://doi.org/10.1016/0002-9149(76)90404-5

27. Clinical guidelines. Ventricular arrhythmias. Sudden cardiac death [Internet]. RSC; 2025 [cited 2025 Sep 9]. Available from: https://webmed.irkutsk.ru/doc/pdf/kr569.pdf

28. Treshkur TV, Tulintseva TE, Parmon EV, et al. Conservative treatment of non-ischemic ventricular arrhythmias: experience and prospects. Russian Journal of Cardiology and Cardiovascular Surgery. 2013;6(5):58-66. (In Russ.)

29. Zhong L, Lee YH, Huang XM, et al. Relative efficacy of catheter ablation vs antiarrhythmic drugs in treating premature ventricular contractions: a single-center retrospective study. Heart Rhythm. 2014;11(2):187–93. https://doi.org/10.1016/j.hrthm.2013.10.033

30. Capucci A, Di Pasquale G, Boriani G, et al. A double-blind crossover comparison of flecainide and slow-release mexiletine in the treatment of stable premature ventricular complexes. Int J Clin Pharmacol Res. 1991; 11(1):23–33.

31. Bokeria LA, Revishvili A, Neminuyushchy. Sudden cardiac death. Moscow: GEOTAR-Media; 2013. 280 p. (In Russ.)

32. Dohrmann ML, Goldschlager N, Cohn K. Ventricular arrhythmia due to physical exertion. In: Cardiac arrhythmias/ Ed by VJ Mandel. Moscow: Medicine; 1996. (In Russ.)

33. Lindow T, Ekström M, Brudin L, et al. Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise. Sci Rep. 2022;12(1):10265. https://doi.org/10.1038/s41598-022-14535-w

34. Cutler MJ, Rosenbaum DS, Dunlap ME. Structural and electrical remodeling as therapeutic targets in heart failure. J Electrocardiol. 2007;40(6):1–7. https://doi.org/10.1016/j.jelectrocard.2007.05.027

35. Hilfiker-Kleiner D, Landmesser U, Drexler H. Molecular mechanisms in heart failure: focus on cardiac hypertrophy, inflammation, angiogenesis, and apoptosis. J Am Coll Cardiol. 2006;48(9):56–66.

36. Kim J, Kwon M, Chang J, et al. Metaanalysis of prognostic implications of exercise-induced ventricular premature complexes in the general population. Am J Cardiol. 2016;118:725–32. https://doi.org/10.1016/j.amjcard.2016.06.007

37. Refaat MM, Gharios C, Moorthy MV, et al. ExerciseInduced Ventricular Ectopy and Cardiovascular Mortality in Asymptomatic Individuals. J Am Coll Cardiol. 2021;78(23): 2267–2277. https://doi.org/10.1016/j.jacc.2021.09.1366

38. Iqbal M, Putra ICS, Kamarullah W, et al. Revisiting exercise-induced premature ventricular complexes as a prognostic factor for mortality in asymptomatic patients: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;29(9):949694.https://doi.org/10.3389/fcvm.2022.949694

39. Curfman GD, Hillis LD. A new look at cardiac exercise testing. N Engl J Med. 2003;348(9):775–776.

40. Osaka M, Saitoh H, Sasabe N, et al. Changes in autonomic activity preceding onset of nonsustained ventricular tachycardia. Ann Noninvasive Electrocardiol. 1996;1(1):3–11. https://doi.org/10.1111/j.1542-474x.1996.tb00256.x

41. Fei L, Statters DJ, Hnatkova K, et al. Change of autonomic influence on the heart immediately before the onset of spontaneous idiopathic ventricular tachycardia. J Am Coll Cardiol. 1994;24:1515–1522. https://doi.org/10.1016/0735-1097(94)90148-1

42. Kishi T. Regulation of the sympathetic nervous system by nitric oxide and oxidative stress in the rostral ventrolateral medulla: 2012 academic conference award from the Japanese society of hypertension. Hypertens Res. 2013;36:845. https://doi.org/10.1038/hr.2013.73

43. Duijvenboden S, Ramírez J, Orini M, et al. Prognostic significance of different ventricular ectopic burdens during submaximal exercise in asymptomatic UK biobank subjects. Circulation. 2023;148(24):1932–1944. https://doi.org/10.1161/CIRCULATIONAHA.123.064633

44. Treshkur TV, Parmon EV, Zhdanova ON, et al. On the choice of antiarrhythmic drug in patients with ventricular arrhythmia of mixed character. Translational Medicine. 2024;11(5):378–387. (In Russ.) https://doi.org/10.18705/2311-4495-2024-11-5-378-387


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For citations:


Zhabina E.S., Volodkin A.S., Treshkur T.V. Ventricular arrhythmias of the recovery period after physical exercise: analysis of the problem. Translational Medicine. 2025;12(4):330-339. (In Russ.) https://doi.org/10.18705/2311-4495-2025-12-4-330-339. EDN: MIKXQE

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ISSN 2311-4495 (Print)
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