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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transmed</journal-id><journal-title-group><journal-title xml:lang="ru">Трансляционная медицина</journal-title><trans-title-group xml:lang="en"><trans-title>Translational Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2311-4495</issn><issn pub-type="epub">2410-5155</issn><publisher><publisher-name>Almazov National Medical Research Centre, Saint Petersburg, Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/2311-4495-2015-0-5-113-122</article-id><article-id custom-type="elpub" pub-id-type="custom">transmed-97</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>К ЮБИЛЕЮ СЗФМИЦ ИМ. В.А. АЛМАЗОВА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TO THE ANNIVERSARY OF FEDERAL ALMAZOV NORTH-WEST MEDICAL RESEARCH CENTRE</subject></subj-group></article-categories><title-group><article-title>ТЕХНИЧЕСКИЕ ОСНОВЫ И КЛИНИЧЕСКОЕ ПРИМЕНЕНИЕ ПОЗИТРОННОЙ ЭМИССИОННОЙ ТОМОГРАФИИ ДЛЯ ОЦЕНКИ ПЕРФУЗИИ МИОКАРДА КАК САМОСТОЯТЕЛЬНОЙ ПРОЦЕДУРЫ И В СОСТАВЕ ГИБРИДНЫХ СИСТЕМ</article-title><trans-title-group xml:lang="en"><trans-title>Technical advances and clinical application of cardiac positron emission tomography for myocardial perfusion assessment as a stand alone technique and having been integrated in the hybrid imaging systems</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыжкова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ryzhkova</surname><given-names>D. V.</given-names></name></name-alternatives><email xlink:type="simple">d_ryjkova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салахова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Salakhova</surname><given-names>A. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Северо-Западный федеральный медицинский исследовательский центр им. В. А. Алмазова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Almazov North-West Medical Research Centre</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2016</year></pub-date><volume>0</volume><issue>5</issue><fpage>113</fpage><lpage>122</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рыжкова Д.В., Салахова А.Р., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Рыжкова Д.В., Салахова А.Р.</copyright-holder><copyright-holder xml:lang="en">Ryzhkova D.V., Salakhova A.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://transmed.almazovcentre.ru/jour/article/view/97">https://transmed.almazovcentre.ru/jour/article/view/97</self-uri><abstract><p>В настоящей статье проанализированы литературные источники, посвященные изучению патологии коронарного кровообращения при сердечно-сосудистых заболеваниях на основании результатов позитронной эмиссионной томографии (ПЭТ) как самостоятельной процедуры и в составе гибридных систем ПЭТ/КТ и ПЭТ/МРТ. Приведены сведения об инновациях в области создания алгоритмов реконструкции ПЭТ изображений. Использование совмещенных диагностических систем позволяет в рамках одного исследования изучить анатомию венечных артерий, оценить гемодинамическую значимость коронарного атеросклероза, сократительную функцию сердца, а также структурное состояние сердечной мышцы и клапанов.</p></abstract><trans-abstract xml:lang="en"><p>This article summarizes data of the studies of myocardial blood flow and coronary flow reserve measurement in the patients with cardiovascular pathology using positron emission tomography (PET) as stand alone technique and as the part of the hybrid systems: PET/CT and PET/MRI. It was given an information, concerning the innovations in PET imaging reconstruction algorithms. Hybrid imaging systems provides an opportunity for advances imaging combining anatomical, physiological, and functional information.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>позитронная эмиссионная томография</kwd><kwd>ПЭТ/КТ</kwd><kwd>ПЭТ/МРТ</kwd><kwd>миокардиальный кровоток</kwd><kwd>коронарный резерв</kwd><kwd>Positron emission tomography</kwd><kwd>PET/CT</kwd><kwd>PET/MRI</kwd><kwd>myocardial blood flow</kwd><kwd>coronary flow reserve</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Терновой С. К., Веселова Т. Н. Выявление нестабильных бляшек в коронарных артериях с помощью мультиспиральной компьютерной томографии. REJR. 2014;4(1):7-13.</mixed-citation><mixed-citation xml:lang="en">Терновой С. К., Веселова Т. Н. Выявление нестабильных бляшек в коронарных артериях с помощью мультиспиральной компьютерной томографии. REJR. 2014;4(1):7-13.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Knaapen P, Haan S, Hoekstra OS et al. Cardiac PET-CT: advanced hybrid imaging for the detection of coronary artery disease. Neth Heart J. 2010;18:90-98.</mixed-citation><mixed-citation xml:lang="en">Knaapen P, Haan S, Hoekstra OS et al. Cardiac PET-CT: advanced hybrid imaging for the detection of coronary artery disease. Neth Heart J. 2010;18:90-98.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Рыжкова Д. В., Нифонтов Е. М., Тютин Л. А. Позитронная эмиссионная томография как метод неинвазивной оценки миокардиального кровотока и коронарного резерва у пациентов с сердечно-сосудистой патологией (литературный обзор). Артериальная гипертензия. 2006;12(3):200-211.</mixed-citation><mixed-citation xml:lang="en">Рыжкова Д. В., Нифонтов Е. М., Тютин Л. А. Позитронная эмиссионная томография как метод неинвазивной оценки миокардиального кровотока и коронарного резерва у пациентов с сердечно-сосудистой патологией (литературный обзор). Артериальная гипертензия. 2006;12(3):200-211.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Рыжкова Д. В. Позитронная эмиссионная томография в комплексной диагностике ишемической болезни сердца: дис.. докт. мед. наук: 14.01.13. Томск, 2008: 342 с.</mixed-citation><mixed-citation xml:lang="en">Рыжкова Д. В. Позитронная эмиссионная томография в комплексной диагностике ишемической болезни сердца: дис.. докт. мед. наук: 14.01.13. Томск, 2008: 342 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">LammertsmaAA, De Silva R,Araujo LL Jones T. Measurement of regional myocardial blood flow using C15O2 and positron emission tomography: comparison of tracer models. Clin Phys Physiol Meets. 1992;13:1-20.</mixed-citation><mixed-citation xml:lang="en">LammertsmaAA, De Silva R,Araujo LL Jones T. Measurement of regional myocardial blood flow using C15O2 and positron emission tomography: comparison of tracer models. Clin Phys Physiol Meets. 1992;13:1-20.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Prior JO, Allenbach G, Valenta I et al. Quantification of myocardial blood flow with 82Rb positron emission tomography: Clinical validation with 15O-water. Eur J Nucl Med Mol Imaging. 2012;39:1037-1047.</mixed-citation><mixed-citation xml:lang="en">Prior JO, Allenbach G, Valenta I et al. Quantification of myocardial blood flow with 82Rb positron emission tomography: Clinical validation with 15O-water. Eur J Nucl Med Mol Imaging. 2012;39:1037-1047.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Danad I, Uusitalo V, Kero T, Saraste A et al. Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: Cutoff values and diagnostic accuracy of quantitative [(15)O]H2O PET imaging. J Am Coll Cardiol. 2014;64:1464-1475.</mixed-citation><mixed-citation xml:lang="en">Danad I, Uusitalo V, Kero T, Saraste A et al. Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: Cutoff values and diagnostic accuracy of quantitative [(15)O]H2O PET imaging. J Am Coll Cardiol. 2014;64:1464-1475.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lubberink М, Harms HJ, Halbmeijer R. Low-Dose Quantitative Myocardial Blood Flow Imaging Using 15O-Water and PET Without Attenuation Correction. J Nucl Med. 2010;51:575-580.</mixed-citation><mixed-citation xml:lang="en">Lubberink М, Harms HJ, Halbmeijer R. Low-Dose Quantitative Myocardial Blood Flow Imaging Using 15O-Water and PET Without Attenuation Correction. J Nucl Med. 2010;51:575-580.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Рыжкова Д. В. Позитронная эмиссионная томография в диагностике заболеваний сердечно-сосудистой системы // в кн.: Лишманов Ю. Б., Чернов В. И. (ред.), Национальное руководство по радионуклидной диагностике. Томск: .</mixed-citation><mixed-citation xml:lang="en">Рыжкова Д. В. Позитронная эмиссионная томография в диагностике заболеваний сердечно-сосудистой системы // в кн.: Лишманов Ю. Б., Чернов В. И. (ред.), Национальное руководство по радионуклидной диагностике. Томск: .</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Beller GA, Bergmann SR. Myocardial perfusion imaging agents: SPECT and PET. J Nucl Cardiol. 2004;11:71-86.</mixed-citation><mixed-citation xml:lang="en">Beller GA, Bergmann SR. Myocardial perfusion imaging agents: SPECT and PET. J Nucl Cardiol. 2004;11:71-86.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hutchins GD. Quantitative evaluation ofmyocardial blood flow with 13 N-ammonia. Cardiology. 1997;88 (1):106-115. 1 3. Yalamanchili P, Hayes WE, Bozek J. Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. J Nucl Cardiol. 2007;14 (6):782-788.</mixed-citation><mixed-citation xml:lang="en">Hutchins GD. Quantitative evaluation ofmyocardial blood flow with 13 N-ammonia. Cardiology. 1997;88 (1):106-115. 1 3. Yalamanchili P, Hayes WE, Bozek J. Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent. J Nucl Cardiol. 2007;14 (6):782-788.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Maddahi J, Czernin J, Lazewatsky J. Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest. J Nucl Med. 2011;52:1490-1498.</mixed-citation><mixed-citation xml:lang="en">Maddahi J, Czernin J, Lazewatsky J. Phase I, First-in-Human Study of BMS747158, a Novel 18F-Labeled Tracer for Myocardial Perfusion PET: Dosimetry, Biodistribution, Safety, and Imaging Characteristics After a Single Injection at Rest. J Nucl Med. 2011;52:1490-1498.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Herrero P, Hartman IT, Green MA et al. Regional myocardial perfusion assessed with generator-produced copper-62-PTSM and PET. J Nucl Med. 1996;37:1294-1300.</mixed-citation><mixed-citation xml:lang="en">Herrero P, Hartman IT, Green MA et al. Regional myocardial perfusion assessed with generator-produced copper-62-PTSM and PET. J Nucl Med. 1996;37:1294-1300.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Qkazawa H, Yonekura Y, Fujibayashi Y et al. Measurement of regional cerebral blood flow with copper-62-PTSM animal three-compartment model. J Nucl Med. 1996;37:1089-1093.</mixed-citation><mixed-citation xml:lang="en">Qkazawa H, Yonekura Y, Fujibayashi Y et al. Measurement of regional cerebral blood flow with copper-62-PTSM animal three-compartment model. J Nucl Med. 1996;37:1089-1093.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wallhaus TR, Lacy J, Whang J, Green MA, Nickles RJ, Stone CK. Human biodistribution and dosimetry of the PET perfusion agent Copper-62-PTSM. J Nucl Med. 1998;39:1958-1964.</mixed-citation><mixed-citation xml:lang="en">Wallhaus TR, Lacy J, Whang J, Green MA, Nickles RJ, Stone CK. Human biodistribution and dosimetry of the PET perfusion agent Copper-62-PTSM. J Nucl Med. 1998;39:1958-1964.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gould K. L. Coronary artery stenosis and reversing atherosclerosis. Arnold, 1999: 689 pp.</mixed-citation><mixed-citation xml:lang="en">Gould K. L. Coronary artery stenosis and reversing atherosclerosis. Arnold, 1999: 689 pp.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kaufmann PA, Camici PG. Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications. J Nucl Med. 2005;45:75-88.</mixed-citation><mixed-citation xml:lang="en">Kaufmann PA, Camici PG. Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications. J Nucl Med. 2005;45:75-88.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hamilton GW, Narahara KA, Yee H, Ritchie JL, Williams DL, Gould KL. Myocardium imaging with Tallium -201 : effect of cardiac drugs on myocardial imaging and absolute tissue distribution. J Nucl Med. 1978;19:10-16.</mixed-citation><mixed-citation xml:lang="en">Hamilton GW, Narahara KA, Yee H, Ritchie JL, Williams DL, Gould KL. Myocardium imaging with Tallium -201 : effect of cardiac drugs on myocardial imaging and absolute tissue distribution. J Nucl Med. 1978;19:10-16.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shah A, Schelbert HR, Schwaiger M, Henze E, Hansen H, Selin C, Huang SC. Measurement of regional myocardial blood flow with N-13 ammonia and positron emission tomography in intact dogs. J Am Coll Cardiol. 1985;5(1):92-100.</mixed-citation><mixed-citation xml:lang="en">Shah A, Schelbert HR, Schwaiger M, Henze E, Hansen H, Selin C, Huang SC. Measurement of regional myocardial blood flow with N-13 ammonia and positron emission tomography in intact dogs. J Am Coll Cardiol. 1985;5(1):92-100.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bol A, Melin JA, Vanoverschelde JL et.al. Direct comparison of [13N]-ammonia and [15O]-water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Circulation. 1993;87(2):512-525.</mixed-citation><mixed-citation xml:lang="en">Bol A, Melin JA, Vanoverschelde JL et.al. Direct comparison of [13N]-ammonia and [15O]-water estimates of perfusion with quantification of regional myocardial blood flow by microspheres. Circulation. 1993;87(2):512-525.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Goldstein RA, Mullani NA, Marani SK, Fisher DJ, Gould KL, O'Brien HA Jr. Myocardial perfusion rubidium-82. II. The effects of metabolic and pharmacologic interventions. J Nucl Med. 1986;24(10):907-915.</mixed-citation><mixed-citation xml:lang="en">Goldstein RA, Mullani NA, Marani SK, Fisher DJ, Gould KL, O'Brien HA Jr. Myocardial perfusion rubidium-82. II. The effects of metabolic and pharmacologic interventions. J Nucl Med. 1986;24(10):907-915.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn JY, Lee DS, Lee JS, Kim SK, Cheon GJ, Yeo JS, Shin SA, Chung JK, Lee MC. Quantification of regional myocardial blood flow using dynamic H215O PET and factor analysis. J Nucl Med. 2001;42(5):782-787.</mixed-citation><mixed-citation xml:lang="en">Ahn JY, Lee DS, Lee JS, Kim SK, Cheon GJ, Yeo JS, Shin SA, Chung JK, Lee MC. Quantification of regional myocardial blood flow using dynamic H215O PET and factor analysis. J Nucl Med. 2001;42(5):782-787.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kety SS. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951;3:1-41.</mixed-citation><mixed-citation xml:lang="en">Kety SS. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev. 1951;3:1-41.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol. 1989;14(3):639-652.</mixed-citation><mixed-citation xml:lang="en">Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol. 1989;14(3):639-652.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Bergmann SR, Fox KA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE. Quantification of regional myocardialblood flow in vivo with H2I5O. Circulation. 1984;70 (4):724-733.</mixed-citation><mixed-citation xml:lang="en">Bergmann SR, Fox KA, Rand AL, McElvany KD, Welch MJ, Markham J, Sobel BE. Quantification of regional myocardialblood flow in vivo with H2I5O. Circulation. 1984;70 (4):724-733.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Araujo LI, Lammertsrna AA, Rhodes CG, et al. Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation. 1991;83(3):875-885.</mixed-citation><mixed-citation xml:lang="en">Araujo LI, Lammertsrna AA, Rhodes CG, et al. Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation. 1991;83(3):875-885.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Hutchins GD1, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15(5):1032-1042.</mixed-citation><mixed-citation xml:lang="en">Hutchins GD1, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15(5):1032-1042.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Choi Y, Huang S-C, Hawkins RA et al. Quantification of myocardial blood flow using 13N-ammonia and PET: comparison of tracer models. J Nucl Med.1999;40(6):1045-1055.</mixed-citation><mixed-citation xml:lang="en">Choi Y, Huang S-C, Hawkins RA et al. Quantification of myocardial blood flow using 13N-ammonia and PET: comparison of tracer models. J Nucl Med.1999;40(6):1045-1055.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Бокерия Л. А., Асланиди И. П., Шурупова И. В. Оценка миокардиальной перфузии // в кн.: Бокерия Л. А., Асланиди И. П., Шурупова И. В. (ред.), Позитронно-эмиссионная томография в каридологии и сердечно-сосудистой хирургии. - М.: изд. “НЦССХ им. А. Н. Бакулева РАМН”, 2010. - С. 69-115.</mixed-citation><mixed-citation xml:lang="en">Бокерия Л. А., Асланиди И. П., Шурупова И. В. Оценка миокардиальной перфузии // в кн.: Бокерия Л. А., Асланиди И. П., Шурупова И. В. (ред.), Позитронно-эмиссионная томография в каридологии и сердечно-сосудистой хирургии. - М.: изд. “НЦССХ им. А. Н. Бакулева РАМН”, 2010. - С. 69-115.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Herrero P1, Markham J, Shelton ME, Weinheimer CJ, Bergmann SR. Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography: exploration of a mathematical model. Circulation. 1990;82 (4):1377-1386.</mixed-citation><mixed-citation xml:lang="en">Herrero P1, Markham J, Shelton ME, Weinheimer CJ, Bergmann SR. Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography: exploration of a mathematical model. Circulation. 1990;82 (4):1377-1386.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary disease. Circulation. 2007; 115:1464-1480.</mixed-citation><mixed-citation xml:lang="en">Di Carli MF, Hachamovitch R. New technology for noninvasive evaluation of coronary disease. Circulation. 2007; 115:1464-1480.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bateman TM, Heller GV, McGhie AL et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT. J Nucl Cardiol. 2006;13(1):24-33.</mixed-citation><mixed-citation xml:lang="en">Bateman TM, Heller GV, McGhie AL et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: comparison with ECG-gated Tc-99m sestamibi SPECT. J Nucl Cardiol. 2006;13(1):24-33.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Berman DS, Maddahi J, Tamarappoo BK et al. Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2013;61:469-477.</mixed-citation><mixed-citation xml:lang="en">Berman DS, Maddahi J, Tamarappoo BK et al. Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography. J Am Coll Cardiol. 2013;61:469-477.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG. Relation between Myocardial Blood Flow and the Severity of Coronary-Artery Stenosis. Eng J Med. 1994;330 (25):1782-1788</mixed-citation><mixed-citation xml:lang="en">Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG. Relation between Myocardial Blood Flow and the Severity of Coronary-Artery Stenosis. Eng J Med. 1994;330 (25):1782-1788</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wilson RF, Marcus ML, White CW. Prediction of the physiologic significance of coronary arterial lesions by quantitative lesion geometry in patients with limited coronary artery disease. Circulation. 1987;75:723-732.</mixed-citation><mixed-citation xml:lang="en">Wilson RF, Marcus ML, White CW. Prediction of the physiologic significance of coronary arterial lesions by quantitative lesion geometry in patients with limited coronary artery disease. Circulation. 1987;75:723-732.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ryzhkova DV, Mostova MI, Zverev OG et al. Use of positron emission tomography and [13N]-ammonia to estimate the relationship between regional myocardial blood flow and coronary artery stenosis severity in patients with coronary heart disease. Eur Radiology. 2005;15 (Suppl. 1):402.</mixed-citation><mixed-citation xml:lang="en">Ryzhkova DV, Mostova MI, Zverev OG et al. Use of positron emission tomography and [13N]-ammonia to estimate the relationship between regional myocardial blood flow and coronary artery stenosis severity in patients with coronary heart disease. Eur Radiology. 2005;15 (Suppl. 1):402.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Demer LL, Gould KL, Goldstein RA et al. Assessment of coronary artery disease severity by positron emission tomography: comparison with quantitative arteriography in 193 patients. Circulation. 1989;79(4):825-835.</mixed-citation><mixed-citation xml:lang="en">Demer LL, Gould KL, Goldstein RA et al. Assessment of coronary artery disease severity by positron emission tomography: comparison with quantitative arteriography in 193 patients. Circulation. 1989;79(4):825-835.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gould KL. Functional measures of coronary stenosis severity at cardiac catheterization. J Am Coll Cardiol. 1990;16:198-199.</mixed-citation><mixed-citation xml:lang="en">Gould KL. Functional measures of coronary stenosis severity at cardiac catheterization. J Am Coll Cardiol. 1990;16:198-199.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Danad I, Uusitalo V, Kero T et al. Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease. Cutoff Values and Diagnostic Accuracy of Quantitative [15O]H2O PET Imaging. J Am Coll Cardiol. 2014;64 (14):1464-1475.</mixed-citation><mixed-citation xml:lang="en">Danad I, Uusitalo V, Kero T et al. Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease. Cutoff Values and Diagnostic Accuracy of Quantitative [15O]H2O PET Imaging. J Am Coll Cardiol. 2014;64 (14):1464-1475.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Gould KL, Kelley KO, Bolson EL. Experimental validation of quantitative coronary arteriography for determining pressure-flow characteristics of coronary stenosis. Circulation. 1982;66:930-937.</mixed-citation><mixed-citation xml:lang="en">Gould KL, Kelley KO, Bolson EL. Experimental validation of quantitative coronary arteriography for determining pressure-flow characteristics of coronary stenosis. Circulation. 1982;66:930-937.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kirkeeide R. L., Gould K. L., Parsel L. Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions. J Am Coll Cardiol. 1986;7:103-113.</mixed-citation><mixed-citation xml:lang="en">Kirkeeide R. L., Gould K. L., Parsel L. Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions. J Am Coll Cardiol. 1986;7:103-113.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Синицын В. Е. Мультиспиральная и электроннолучевая томография сердца // в кн.: Шляхто Е. В. (ред.), Кардиология. - Москва: “ГЕОТАР-Медиа”, 2015. - С. 139-148.</mixed-citation><mixed-citation xml:lang="en">Синицын В. Е. Мультиспиральная и электроннолучевая томография сердца // в кн.: Шляхто Е. В. (ред.), Кардиология. - Москва: “ГЕОТАР-Медиа”, 2015. - С. 139-148.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fischer JJ, Samady H, Pherson JA et al. Comparison between visual assessment and quantitative angiography versus fractional How reserve for native coronary narrowings of moderate severity. Am J Cardiol. 2002;90:205-210.</mixed-citation><mixed-citation xml:lang="en">Fischer JJ, Samady H, Pherson JA et al. Comparison between visual assessment and quantitative angiography versus fractional How reserve for native coronary narrowings of moderate severity. Am J Cardiol. 2002;90:205-210.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Heller LA, Gates C, Popma J et al. Intracoronary Doppler assessment of moderate coronary artery disease: comparison with 20IT1 imaging and coronary angiography. FACTS study group. Circulation. 1997;96(2):484-490.</mixed-citation><mixed-citation xml:lang="en">Heller LA, Gates C, Popma J et al. Intracoronary Doppler assessment of moderate coronary artery disease: comparison with 20IT1 imaging and coronary angiography. FACTS study group. Circulation. 1997;96(2):484-490.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Okayama H, Sumimoto T, Hiasa G et al. Assessment of intermediate steno sis in the left anterior descending coronary artery with contrast-enhanced transthoracic Doppler echocardiography. Coron Artery Dis. 2003;14:247-254.</mixed-citation><mixed-citation xml:lang="en">Okayama H, Sumimoto T, Hiasa G et al. Assessment of intermediate steno sis in the left anterior descending coronary artery with contrast-enhanced transthoracic Doppler echocardiography. Coron Artery Dis. 2003;14:247-254.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Di Carli MF, Murthy VL. Cardiac PET/CT for the evaluation of known or suspected coronary artery disease. Radiographics. 2011;31:1239-1254.</mixed-citation><mixed-citation xml:lang="en">Di Carli MF, Murthy VL. Cardiac PET/CT for the evaluation of known or suspected coronary artery disease. Radiographics. 2011;31:1239-1254.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Kajander S, Joutsiniemi E, Saraste M et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation. 2010;122(6):603-613.</mixed-citation><mixed-citation xml:lang="en">Kajander S, Joutsiniemi E, Saraste M et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation. 2010;122(6):603-613.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy VL, Naya M, Foster CR et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124(20):2215-2224.</mixed-citation><mixed-citation xml:lang="en">Murthy VL, Naya M, Foster CR et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124(20):2215-2224.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Naya M, Murthy VL, Taqueti VR et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med. 2014;55:248-255.</mixed-citation><mixed-citation xml:lang="en">Naya M, Murthy VL, Taqueti VR et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med. 2014;55:248-255.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Ziadi MC, Dekemp RA, Williams K, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol. 2012;19:670-680.</mixed-citation><mixed-citation xml:lang="en">Ziadi MC, Dekemp RA, Williams K, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol. 2012;19:670-680.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy VL, Naya M, Foster CR et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging. 2012;5:1025-1034.</mixed-citation><mixed-citation xml:lang="en">Murthy VL, Naya M, Foster CR et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging. 2012;5:1025-1034.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Naya M, Murthy VL, Foster CR et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol. 2013;61:2098-2106.</mixed-citation><mixed-citation xml:lang="en">Naya M, Murthy VL, Foster CR et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol. 2013;61:2098-2106.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy VL, Naya M, Foster CR et al. Association between Coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation. 2012;126:1858-1868.</mixed-citation><mixed-citation xml:lang="en">Murthy VL, Naya M, Foster CR et al. Association between Coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation. 2012;126:1858-1868.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Schenker MP, Dorbala S, Hong EC et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study. Circulation. 2008;117:1693-1700.</mixed-citation><mixed-citation xml:lang="en">Schenker MP, Dorbala S, Hong EC et al. Interrelation of coronary calcification, myocardial ischemia, and outcomes in patients with intermediate likelihood of coronary artery disease: a combined positron emission tomography/computed tomography study. Circulation. 2008;117:1693-1700.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Chang S. M., Nabi F., Xu J., et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol. 2009;54:1872-1882.</mixed-citation><mixed-citation xml:lang="en">Chang S. M., Nabi F., Xu J., et al. The coronary artery calcium score and stress myocardial perfusion imaging provide independent and complementary prediction of cardiac risk. J Am Coll Cardiol. 2009;54:1872-1882.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Jaarsma C., Leiner T., Bekkers S. C., et al. Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis. J Am Coll Cardiol. 2012;59:1719-1728. 5(34) / 2015</mixed-citation><mixed-citation xml:lang="en">Jaarsma C., Leiner T., Bekkers S. C., et al. Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis. J Am Coll Cardiol. 2012;59:1719-1728. 5(34) / 2015</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Kurita T., Sakuma H., Onishi K., et al. Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire. Eur Heart J. 2009;30:444-452.</mixed-citation><mixed-citation xml:lang="en">Kurita T., Sakuma H., Onishi K., et al. Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire. Eur Heart J. 2009;30:444-452.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Costa M.A., Shoemaker S., Futamatsu H., et al. Quantitative magnetic resonance perfusion imaging detects anatomic and physiologic coronary artery disease as measured by coronary angiography and fractional flow reserve. J Am Coll Cardiol. 2007;50:514-522.</mixed-citation><mixed-citation xml:lang="en">Costa M.A., Shoemaker S., Futamatsu H., et al. Quantitative magnetic resonance perfusion imaging detects anatomic and physiologic coronary artery disease as measured by coronary angiography and fractional flow reserve. J Am Coll Cardiol. 2007;50:514-522.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Adenaw N, Salerno M. PET/MRI: current state of the art and future potential for cardiovascular applications. J Nucl Cardiol. 2013;20:976-989.</mixed-citation><mixed-citation xml:lang="en">Adenaw N, Salerno M. PET/MRI: current state of the art and future potential for cardiovascular applications. J Nucl Cardiol. 2013;20:976-989.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
