transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2024-11-3-248-252transmed-937Research ArticleОБЗОРЫПрокальцитонин как маркер патологических состояний организма при инфекционных осложнениях (обзор литературы)Procalcitonin as a marker of pathological conditions of the body during infectious complications (literature review)https://orcid.org/0000-0002-5280-6511АлексееваН. С.AlekseevaN. S.

Алексеева Наталья Сергеевна, к.м.н., доцент кафедры нормальной физиологии ФГБОУ ВО РостГМУ Минздрава России

пер. Нахичеванский, д. 29, Ростов-на-Дону, 344022

Alekseeva Natalya Sergeevna, Ph.D. med. Sciences, Associate Professor of the Department of Normal Physiology

Nakhichevansky Lane, 29, Rostov-on-Don, 344022

alekseeva_ns@rostgmu.ruhttps://orcid.org/0000-0002-8055-2184АлексеевВ. В.AlekseevV. V.

Алексеев Владимир Вячеславович, д.м.н., заведующий кафедрой гистологии, цитологии и эмбриологии ФГБОУ ВО РостГМУ Минздрава России

Ростов-на-Дону

Alekseev Vladimir Vyacheslavovich, Dr. med. Sciences, Head. Department of Histology, Cytology and Embryology

Rostov-on-Don

alekseev_vv@rostgmu.ruhttps://orcid.org/0000-0001-7452-6994КуцеваловаО. Ю.KutsevalovaO. Yu.

Куцевалова Ольга Юрьевна, к.б.н., ФГБУ «НМИЦ онкологии» Минздрава России

Ростов-на-Дону

Kutsevalova Olga Yurievna, Ph.D. biol. Sciences

Rostov-on-Don

olga_kutsevalova@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Ростовский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияRostov State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской ФедерацииРоссияNational Medical Research Center of OncologyRussian Federation202404082024113248252Copyright © Алексеева Н.С., Алексеев В.В., Куцевалова О.Ю., 20242024Алексеева Н.С., Алексеев В.В., Куцевалова О.Ю.Alekseeva N.S., Alekseev V.V., Kutsevalova O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/937

Одной из проблем практического здравоохранения являются инфекционные осложнения и как наиболее серьезная угроза для здоровья человечества по всему земному шару — устойчивость к антибиотикам. Несмотря на современный арсенал методов диагностики и лечения, летальность при инфекционных осложнениях остается высокой. В связи с этим, в настоящее время ведется активный поиск достоверных биологических маркеров для своевременной диагностики инфекционных осложнений. Особый интерес представляют текущее состояние и последние достижения в диагностике с помощью прокальцитонина, как для дифференциации патогенеза инфекционного и неинфекционного процессов, так и для оптимизации применения антибиотиков.

В обзоре представлены современные данные о прокальцитонине как специфическом биомаркере бактериальной инфекции. Показаны различные возможные применения прокальцитонина в клинической практике.

One of the problems of practical healthcare is infectious complications and, as the most serious threat to human health around the globe, antibiotic resistance. Despite the modern arsenal of diagnostic and treatment methods, mortality from infectious complications remains high. In this regard, an active search is currently underway for reliable biological markers for the timely diagnosis of infectious complications. Of particular interest is the current status and recent advances in diagnostics using procalcitonin, both for differentiating the pathogenesis of infectious and non-infectious processes, as well as for optimizing the use of antibiotics.

The review presents current data on procalcitonin as a specific biomarker of bacterial infection. Various possible uses of procalcitonin in clinical practice are shown.

биологический маркер (биомаркер)микробиологическая диагностикапрокальцитонинсепсисbiological marker (biomarker)microbiological diagnosticsprocalcitoninsepsisReferencesКуцевалова О.Ю., Покудина И.О., Розенко Д.А. и др. Современные проблемы антибиотикорезистентности грамотрицательных возбудителей нозокомиальных инфекций в Ростовской области. Медицинский вестник Юга России. 2019;10(3):91–96. DOI: 10.21886/2219-8075-2019-10-3-91-96.Kutsevalova OYu, Pokudina IO, Rozenko DA, et al. Modern problems of antibiotic resistance of gram-negative pathogens of nosocomial infections in the Rostov region. Medical Bulletin of the South of Russia. 2019;10(3):91–96. In Russian DOI: 10.21886/2219-8075-2019-10-3-91-96.Pierrakos C, Velissaris D, Bisdorff M, et al. Biomarkers of sepsis: time for a reappraisal. Crit Care. 2020 Jun 5;24(1):287. DOI: 10.1186/s13054-020-02993-5.Pierrakos C, Velissaris D, Bisdorff M, et al. Biomarkers of sepsis: time for a reappraisal. Crit Care. 2020 Jun 5;24(1):287. DOI: 10.1186/s13054-020-02993-5.Гуськова Н.К., Морозова А.А., Розенко Д.А. и др. Пресепсин как маркер сепсиса у онкологических больных после хирургических вмешательств. Южно-Российский онкологический журнал. 2022;3(2):6–13. DOI:10.37748/2686-9039-2022-3-2-1.Guskova NK, Morozova AA, Rozenko DA, et al. Presepsin as a marker of sepsis in cancer patients after surgical interventions. South Russian Journal of Oncology. 2022;3(2):6–13. In Russian DOI:10.37748/2686-9039-2022-3-2-1.Kaal A, Snel L, Dane M, et al. Diagnostic yield of bacteriological tests and predictors of severe outcome in adult patients with COVID-19 presenting to the emergency department. Emerg Med J. 2021;38(9): 685–691. DOI: 10.1136/emermed-2020-211027.Kaal A, Snel L, Dane M, et al. Diagnostic yield of bacteriological tests and predictors of severe outcome in adult patients with COVID-19 presenting to the emergency department. Emerg Med J. 2021;38(9): 685–691. DOI: 10.1136/emermed-2020-211027.Куцевалова О.Ю., Лысенко И.Б., Козель Ю.Ю. Комплексный подход к диагностике бактериальных и грибковых инфекций кровотока у пациентов онкологического профиля. Южно-Российский онкологический журнал. 2020;1(4):15–21. DOI:10.37748/2687-0533-2020-1-4-2.Kutsevalova OYu, Lysenko IB, Kozel YuYu, et al. An integrated approach to the diagnosis of bacterial and fungal bloodstream infections in oncology patients. South Russian Journal of Oncology. 2020;1(4):15–21. In Russian DOI:10.37748/2687-0533-2020-1-4-2.Mobed A, Darvishi M, Tahavvori A, et al. Nanobiosensors for procalcitonin (PCT) analysis. J Clin Lab Anal. 2024;38(3): e25006. DOI: 10.1002/jcla.25006.Mobed A, Darvishi M, Tahavvori A, et al. Nanobiosensors for procalcitonin (PCT) analysis. J Clin Lab Anal. 2024;38(3): e25006. DOI: 10.1002/jcla.25006.Van Engelen TSR, Wiersinga WJ, Scicluna BP, et al. Biomarkers in Sepsis. Crit Care Clin. 2018; 34(1):139– 152. DOI: 10.1016/j.ccc.2017.08.010.Van Engelen TSR, Wiersinga WJ, Scicluna BP, et al. Biomarkers in Sepsis. Crit Care Clin. 2018; 34(1):139– 152. DOI: 10.1016/j.ccc.2017.08.010.Lu CY, Kao CL, Hung KC, et al. Diagnostic efficacy of serum presepsin for postoperative infectious complications: a meta-analysis. Front Immunol. 2023;12; 14:1320683. DOI: 10.3389/fimmu.2023.1320683.Lu CY, Kao CL, Hung KC, et al. Diagnostic efficacy of serum presepsin for postoperative infectious complications: a meta-analysis. Front Immunol. 2023;12; 14:1320683. DOI: 10.3389/fimmu.2023.1320683.Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. DOI: 10.1007/s00134-021-06506-y.Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181–1247. DOI: 10.1007/s00134-021-06506-y.Wang Q, Liu H, Zou L, et al. Early predictors of bacterial pneumonia infection in children with congenital heart disease after cardiopulmonary bypass: a single-centre retrospective study. BMJ Open. 2024;14(3): e076483. DOI: 10.1136/bmjopen-2023-076483.Wang Q, Liu H, Zou L, et al. Early predictors of bacterial pneumonia infection in children with congenital heart disease after cardiopulmonary bypass: a single-centre retrospective study. BMJ Open. 2024;14(3): e076483. DOI: 10.1136/bmjopen-2023-076483.Tatsuoka T, Okuyama T, Takeshita E, et al. Early detection of infectious complications using C-reactive protein and the procalcitonin levels after laparoscopic colorectal resection: aprospective cohort study. Surg Today. 2021;51(3):397–403. DOI:10.1007/s00595-020-02111-6.Tatsuoka T, Okuyama T, Takeshita E, et al. Early detection of infectious complications using C-reactive protein and the procalcitonin levels after laparoscopic colorectal resection: aprospective cohort study. Surg Today. 2021;51(3):397–403. DOI:10.1007/s00595-020-02111-6.Vasavada B, Patel H. Postoperative serum procalcitonin versus C-reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta-analysis. ANZ J Surg. 2021;91(5):E260– E270. DOI: 10.1111/ans.16639.Vasavada B, Patel H. Postoperative serum procalcitonin versus C-reactive protein as a marker of postoperative infectious complications in pancreatic surgery: a meta-analysis. ANZ J Surg. 2021;91(5):E260– E270. DOI: 10.1111/ans.16639.Rashwan NI, Hassan MH, Mohey El-Deen ZM, et al. Validity of biomarkers in screening for neonatal sepsis - A single center -hospital based study. Pediatr Neonatol. 2019;60(2):149–155. DOI: 10.1016/j.pedneo.2018.05.001.Rashwan NI, Hassan MH, Mohey El-Deen ZM, et al. Validity of biomarkers in screening for neonatal sepsis - A single center -hospital based study. Pediatr Neonatol. 2019;60(2):149–155. DOI: 10.1016/j.pedneo.2018.05.001.Saura O, Luyt CE. Procalcitonin as a biomarker to guide treatments for patients with lower respiratory tract infections. Expert Review of Respiratory Medicine. 2023;17(8):651–661. DOI:10.1080/17476348.2023.2251394.Saura O, Luyt CE. Procalcitonin as a biomarker to guide treatments for patients with lower respiratory tract infections. Expert Review of Respiratory Medicine. 2023;17(8):651–661. DOI:10.1080/17476348.2023.2251394.Lu Y, Song L. Clinical Significance of Procalcitonin, Lactic Acid, and Endotoxin Testing for Children With Severe Pneumonia and Sepsis. Altern Ther Health Med. 2023;29(3):218–223.Lu Y, Song L. Clinical Significance of Procalcitonin, Lactic Acid, and Endotoxin Testing for Children With Severe Pneumonia and Sepsis. Altern Ther Health Med. 2023;29(3):218–223.Kouritas V, Zissis C, Bellenis I. Procalcitonin Measurement in Pleural Fluid to Predict Infectious Complications of the Chest Post Lung Resection. J Invest Surg. 2021;34(12):1317–1321. DOI: 10.1080/08941939.2020.1801912.Kouritas V, Zissis C, Bellenis I. Procalcitonin Measurement in Pleural Fluid to Predict Infectious Complications of the Chest Post Lung Resection. J Invest Surg. 2021;34(12):1317–1321. DOI: 10.1080/08941939.2020.1801912.Florin TA, Ambroggio L, Brokamp C, et al. Biomarkers and Disease Severity in Children With Community-Acquired Pneumonia. Pediatrics. 2020;145(6):e20193728. DOI:10.1542/peds.2019-3728.Florin TA, Ambroggio L, Brokamp C, et al. Biomarkers and Disease Severity in Children With Community-Acquired Pneumonia. Pediatrics. 2020;145(6):e20193728. DOI:10.1542/peds.2019-3728.Roth L, Eshmuminov D, Russo L, et al. Serum procalcitonin improves diagnosis of infectious complications after CRS/HIPEC. World J Surg Oncol. 2023;12;21(1):5. DOI: 10.1186/s12957-022-02884-9.Roth L, Eshmuminov D, Russo L, et al. Serum procalcitonin improves diagnosis of infectious complications after CRS/HIPEC. World J Surg Oncol. 2023;12;21(1):5. DOI: 10.1186/s12957-022-02884-9.Dockree S, Brook J, James T, et al. A pregnancy-specific reference interval for procalcitonin. Clin Chim Acta. 2021;513:13–16. DOI: 10.1016/j.cca.2020.12.007.Dockree S, Brook J, James T, et al. A pregnancy-specific reference interval for procalcitonin. Clin Chim Acta. 2021;513:13–16. DOI: 10.1016/j.cca.2020.12.007.Beaumont R, Tang K, Gwee A. The Sensitivity and Specificity of Procalcitonin in Diagnosing Bacterial Sepsis in Neonates. Hosp Pediatr. 2024;14(3):199–208. DOI: 10.1542/hpeds.2023-007318.Beaumont R, Tang K, Gwee A. The Sensitivity and Specificity of Procalcitonin in Diagnosing Bacterial Sepsis in Neonates. Hosp Pediatr. 2024;14(3):199–208. DOI: 10.1542/hpeds.2023-007318.Dolci A, Robbiano C, Aloisio E, et al. Searching for a role of procalcitonin determination in COVID-19: a study on a selected cohort of hospitalized patients. Clin Chem Lab Med. 2020;59(2):433–440. DOI: 10.1515/cclm-2020-1361.Dolci A, Robbiano C, Aloisio E, et al. Searching for a role of procalcitonin determination in COVID-19: a study on a selected cohort of hospitalized patients. Clin Chem Lab Med. 2020;59(2):433–440. DOI: 10.1515/cclm-2020-1361.Heer RS, Mandal AK, Kho J, et al. Elevated procalcitonin concentrations in severe COVID-19 may not reflect bacterial co-infection. Annals of Clinical Biochemistry. 2021;58(5):520–527. DOI: 10.1177/00045632211022380.Heer RS, Mandal AK, Kho J, et al. Elevated procalcitonin concentrations in severe COVID-19 may not reflect bacterial co-infection. Annals of Clinical Biochemistry. 2021;58(5):520–527. DOI: 10.1177/00045632211022380.Martin-Loeches I, Torres A, Nagavci B, et al. ERS/ ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Eur Respir J. 2023;61(4):2200735. DOI: 10.1183/13993003.00735-2022.Martin-Loeches I, Torres A, Nagavci B, et al. ERS/ ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Eur Respir J. 2023;61(4):2200735. DOI: 10.1183/13993003.00735-2022.Клинические рекомендации. 2022] URL: https://www.antibiotic.ru/files/306/kr-sepsis-vzroslye.pdfSepsis (in adults). Clinical recommendations. 2022. (In Russ.) https://www.antibiotic.ru/ files/306/kr-sepsis-vzroslye.pdfFarias JS, Villarreal EG, Dhargalkar J, et al. C-reactive protein and procalcitonin after congenital heart surgery utilizing cardiopulmonary bypass: When should we be worried? J Card Surg. 2021;36(11):4301–4307. DOI: 10.1111/jocs.15952.Farias JS, Villarreal EG, Dhargalkar J, et al. C-reactive protein and procalcitonin after congenital heart surgery utilizing cardiopulmonary bypass: When should we be worried? J Card Surg. 2021;36(11):4301–4307. DOI: 10.1111/jocs.15952.Schuetz P. How to best use procalcitonin to diagnose infections and manage antibiotic treatment. Clin Chem Lab Med. 2022;61(5):822–828. DOI: 10.1515/cclm-2022-1072.Schuetz P. How to best use procalcitonin to diagnose infections and manage antibiotic treatment. Clin Chem Lab Med. 2022;61(5):822–828. DOI: 10.1515/cclm-2022-1072.Ivaska L, Herberg J, Sadarangani M. Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers. J Infect. 2024;88(3):106111. DOI: 10.1016/j.jinf.2024.01.010.Ivaska L, Herberg J, Sadarangani M. Distinguishing community-acquired bacterial and viral meningitis: Microbes and biomarkers. J Infect. 2024;88(3):106111. DOI: 10.1016/j.jinf.2024.01.010.

The authors declare that there are no conflicts of interest present.