transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2024-11-1-6-18AFQHOMtransmed-919Research ArticleАЛЛЕРГОЛОГИЯ И ИММУНОЛОГИЯALLERGY AND IMMUNOLOGYОсобенности течения и диагностики хронического саркоидозаFeatures of the course and diagnosis of chronic sarcoidosisБергЕ. Е.BergE. E.

Елизавета Евгеньевна Берг, студент 6 курса

медицинский факультет

197341; ул. Аккуратова д. 2

Санкт-Петербург

тел.: +79658149803

Elizaveta E. Berg, 6-th year student

medical faculty

197341; ul. Akkuratova d. 2; Saint Petersburg

tel.: +79658149803

elevgberg@gmail.comКудрявцевИ. В.KudryavtsevI. V.

Игорь Владимирович Кудрявцев, к. б. н., заведующий лабораторией

лаборатория клеточной иммунологии

Санкт-Петербург

Igor V. Kudryavtsev, PhD., Head of laboratory

Institute of Experimental Medicine; laboratory of cellular immunology

Saint Petersburg

https://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. A.

Дмитрий Анатольевич Кудлай, д. м. н., член-корреспондент РАН, профессор, профессор кафедры, ведущий научный сотрудник

Институт фармации; кафедра фармакологии; факультет фундаментальной медицины; кафедра фармакогнозии и промышленной фармации; ФГБУ «ГНЦ Институт иммунологии»; лаборатория персонализированной медицины и молекулярной иммунологии № 71

115552; Каширское шоссе, 24; Москва

Scopus AuthorID: https://www.scopus.com/authid/detail.uri?authorId=57225772840

тел.: +79857610237

Dmitry A. Kudlay DMedSci, MD, corresponding member of the Russian Academy of Sciences, Professor, Professor of the Department, Leading Researcher

Institute of Pharmacy; Department of Pharmacology; Faculty of Fundamental Medicine; Department of Pharmacognosyand Industrial Pharmacy; NRC Institute of Immunology; Laboratory of Personalized Medicine and Molecular Immunology

115552; Kashirskoye highway; Moscow

Scopus AuthorID: https://www.scopus.com/authid/detail.uri?authorId=57225772840

tel.: +79857610237

D624254@gmail.comhttps://orcid.org/0000-0002-9023-6986СтаршиноваА. А.StarshinovaA. A.

Анна Андреевна Старшинова, д. м. н., профессор, начальник Управления

кафедра факультетской терапии с клиникой; Управление научными исследованиями

115552; Каширское шоссе, 24; Санкт-Петербург

e-mail: starshinova_777@mail.ru,

Anna A. Starshinova, DMedSci, MD, pulmonologist,Head of the department

research department

197341; Akkuratova str., 2; Saint Petersburg

email: starshinova_777@mail.ru

tel.: +79052043861

starshinova_aa@almazovcentre.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationФедеральное государственное бюджетное научное учреждение «Институт экспериментальной медицины»РоссияScientific Research Institute of Experimental MedicineRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И. М. Сеченова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства; Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный университет имени М. В. Ломоносова»РоссияSechenov First Moscow State Medical University; National Research Center — Institute of Immunology Federal Medical- Biological Agency; Lomonosov Moscow State UniversityRussian Federation202409042024111618Copyright © Берг Е.Е., Кудрявцев И.В., Кудлай Д.А., Старшинова А.А., 20242024Берг Е.Е., Кудрявцев И.В., Кудлай Д.А., Старшинова А.А.Berg E.E., Kudryavtsev I.V., Kudlay D.A., Starshinova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/919

   Саркоидоз — системное воспалительное заболевание неизвестной этиологии с широким спектром клинических проявлений. Ежегодная заболеваемость колеблется от 1 до 15 на 100 000 населения. В связи с отсутствием специфических клинических проявлений диагностика данного заболевания все еще затруднена. Большая вариабельность клинических проявлений и органов-мишеней, а также сопутствующие заболевания сильно усложняют диагностический поиск и делают саркоидоз диагнозом исключения. В настоящей статье рассмотрен клинический случай пациента с генерализованным саркоидозом, а также проведен обзор и анализ современной литературы по данному вопросу. На сегодня не существует биомаркеров или их комбинации, которые бы позволили надежно предсказать развитие и распространение патологического процесса. Для наиболее точной диагностики и определения прогноза необходимо существование одного серологического или визуализирующего маркера, обладающего достаточной чувствительностью и специфичностью.

   Sarcoidosis is a systemic inflammatory disease of unknown etiology with a wide range of clinical manifestations. The annual incidence ranges from 1 to 15 per 100,000 population. Due to the lack of specific clinical features, the diagnosis of this disease is still challenging. The significant variability in clinical presentations and target organs, as well as concomitant diseases, greatly complicate the diagnostic search and make sarcoidosis a diagnosis of exclusion. This article discusses a clinical case of a patient with generalized chronic sarcoidosis and provides a review and analysis of the current literature on this issue. At the moment, there is no biomarker or combination of biomarkers that would reliably predict the development and spread of the pathological process.

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Clinical Presentations, Pathogenesis, and Therapy of Sarcoidosis: State of the Art. J Clin Med. 2020; 9(8):2363. DOI: 10.3390/jcm9082363.Starshinova AA, Malkova АM, Zinchenko YuS, et al. Autoimmune component in the etiology of sarcoidosis. uberculosis and Lung Diseases, 2020, Vol. 98, No. 5, P. 54–62. In Russian DOI: 10.21292/2075-1230-2020-98-5-54-62.Starshinova AA, Malkova АM, Zinchenko YuS, et al. Autoimmune component in the etiology of sarcoidosis. uberculosis and Lung Diseases, 2020, Vol. 98, No. 5, P. 54–62. In Russian DOI: 10.21292/2075-1230-2020-98-5-54-62.Gavrilova N, Zinchenko Y, Belyaeva E, et al. Small Fiber Neuropathy in Sarcoidosis. Pathophysiology. 2021; 28(4):544–550. DOI: 10.3390/pathophysiology28040035.Gavrilova N, Zinchenko Y, Belyaeva E, et al. Small Fiber Neuropathy in Sarcoidosis. Pathophysiology. 2021; 28(4):544–550. DOI: 10.3390/pathophysiology28040035.Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020; 201(8):e26–e51. DOI: 10.1164/rccm.202002-0251ST.Crouser ED, Maier LA, Wilson KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020; 201(8):e26–e51. DOI: 10.1164/rccm.202002-0251ST.Akao K, Minezawa T, Yamamoto N, et al. Flow cytometric analysis of lymphocyte profiles in mediastinal lymphadenopathy of sarcoidosis. PLoS One. 2018; 13(11):e0206972. DOI: 10.1371/journal.pone.0206972.Akao K, Minezawa T, Yamamoto N, et al. Flow cytometric analysis of lymphocyte profiles in mediastinal lymphadenopathy of sarcoidosis. PLoS One. 2018; 13(11):e0206972. DOI: 10.1371/journal.pone.0206972.Obi ON, Saketkoo LA, Russell AM, et al. Sarcoidosis: Updates on therapeutic drug trials and novel treatment approaches. Front Med (Lausanne). 2022; 9:991783. DOI: 10.3389/fmed.2022.991783.Obi ON, Saketkoo LA, Russell AM, et al. Sarcoidosis: Updates on therapeutic drug trials and novel treatment approaches. Front Med (Lausanne). 2022; 9:991783. DOI: 10.3389/fmed.2022.991783.Jeny F, Bernaudin JF, Cohen Aubart F, et al. Diagnosis issues in sarcoidosis. Respir Med Res. 2020; 77:37–45. DOI: 10.1016/j.resmer.2019.09.002.Jeny F, Bernaudin JF, Cohen Aubart F, et al. Diagnosis issues in sarcoidosis. Respir Med Res. 2020; 77:37–45. DOI: 10.1016/j.resmer.2019.09.002.Kraaijvanger R, Janssen Bonás M, Vorselaars ADM, et al. Biomarkers in the Diagnosis and Prognosis of Sarcoidosis: Current Use and Future Prospects. Front Immunol. 2020; 11:1443. DOI: 10.3389/fimmu.2020.01443.Kraaijvanger R, Janssen Bonás M, Vorselaars ADM, et al. Biomarkers in the Diagnosis and Prognosis of Sarcoidosis: Current Use and Future Prospects. Front Immunol. 2020; 11:1443. DOI: 10.3389/fimmu.2020.01443.Ramos-Casals M, Retamozo S, Sisó-Almirall A, et al. 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The authors declare that there are no conflicts of interest present.