transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2023-10-6-557-565NTFRNPtransmed-869Research ArticleМОЛЕКУЛЯРНАЯ БИОЛОГИЯ И ГЕНЕТИКАРыбы Danio rerio как модель для изучения внеклеточных везикул.Zebrafish as a model for studing extracellular vesicles.КалининаО. В.KalininaO. V.

Калинина Ольга Викторовна, д.б.н., доцент, ведущий научный сотрудник научно-исследовательской лаборатории аутоиммунных и аутовоспалительных заболеваний научно-исследовательского центра неизвестных, редких и генетически обусловленных заболеваний НЦМУ «Центр персонализированной медицины», профессор кафедры лабораторной медицины и генетики Института медицинского образования

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Olga V. Kalinina, Doctor of Medicine, Associate Professor, Leading Researcher at the Research Laboratory of Autoimmune and Autoinflammatory Diseases, Research Center of Unknown, Rare and Genetically Determined Diseases of the World-Class Research Center for Personalized Medicine; Professor at the Department of Laboratory Medicine and Genetics, Institute of Medical Education

olgakalinina@mail.ruСамбурД. Б.SamburD. B.

Самбур Дарина Борисовна, клинический ординатор кафедры лабораторной медицины и генетики Института медицинского образования; лаборант-исследователь научно-исследовательской лаборатории аутоиммунных и аутовоспалительных заболеваний научно-исследовательского центра неизвестных, редких и генетически обусловленных заболеваний НЦМУ «Центр персонализированной медицины»

Darina B. Sambur, clinical resident of the Department of Laboratory Medicine and Genetics, Institute of Medical Education; research laboratory assistant at the Research Laboratory of Autoimmune and Autoinflammatory Diseases, Research Center of Unknown, Rare and Genetically Determined Diseases of the World-Class Research Center for Personalized Medicine

КоролеваЕ. Е.KorolevaE. E.

Королева Елизавета Евгеньевна, лаборант-исследователь Института молекулярной биологии и генетики

Elizaveta E. Koroleva, research laboratory assistant at the Institute of Molecular Biology and Genetics

ГоловкинА. С.GolovkinA. S.

Головкин Алексей Сергеевич, д.м.н., руководительгруппы генно-клеточной инженерии Института молекулярной биологии и генетики ФГБУ «НМИЦ им.В. А. Алмазова» Минздрава России, ведущий научныйсотрудник научно-исследовательской лаборатории аутоиммунных и аутовоспалительных заболеваний научно-исследовательского центра неизвестных, редких и генетически обусловленных заболеваний НЦМУ «Центрперсонализированной медицины», профессор кафедрыклеточной биологии и гистологии Института медицинского образования

Aleksey S. Golovkin, Doctor of Medicine, Head of the Group of Genetic Cell Engineering, Institute of Molecular Biology and Genetics of the Almazov National Medical Research Centre; Leading Researcher at the Research Laboratory of Autoimmune and Autoinflammatory Diseases, Research Center of Unknown, Rare and Genetically Determined Diseases of the World-Class Research Center for Personalized Medicine; Professor at the Department of Cell Biology and Histology, Institute of Medical Education

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation202312012024106557565Copyright © Калинина О.В., Самбур Д.Б., Королева Е.Е., Головкин А.С., 20242024Калинина О.В., Самбур Д.Б., Королева Е.Е., Головкин А.С.Kalinina O.V., Sambur D.B., Koroleva E.E., Golovkin A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/869

На основании литературных данных была проведена оценка возможности использования рыб Danio rerio в качестве модели для изучения внеклеточных везикул (ВВ). В частности, описаны модельные эксперименты по оценке вклада ВВ в регуляцию патологических и физиологических процессов (ишемические, реперфузионные, механические повреждения тканей и органов, развитие местного и системного иммунного ответа, опухолевого роста и метастазирования и т. д.), биодоступности и распределения в тканях и органах введенных ВВ, эффектов экзогенных ВВ как терапевтических агентов.

It was evaluated the feasibility of using Zebrafish as a model to study extracellular vesicles (EVs) based on literature. Particularly, it was described experimental models that were used to assess the contribution of the EVs in the regulation of pathological and physiological processes (ischemic, reperfusion, mechanical damage to tissues and organs, development of local and systemic immune response, tumor growth and metastasis, etc.), the bioavailability and the distribution of injected EVs in different tissues and organs, the effects of exogenous EVs as therapeutic agents.

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The authors declare that there are no conflicts of interest present.