transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-4495-2023-10-3-183-208transmed-856Research ArticleСЕРДЕЧНО-СОСУДИСТЫЕ ЗАБОЛЕВАНИЯCARDIOVASCULAR MEDICINEМЕТААНАЛИЗ ЗАВИСИМОСТИ РАЗВИТИЯ ЭКСПЕРИМЕНТАЛЬНОЙ РЕНОВАСКУЛЯРНОЙ ГИПЕРТЕНЗИИ «2 ПОЧКИ, 1 ЗАЖИМ» ОТ ФАКТОРОВ, СВЯЗАННЫХ С ОБРАЗОМ ЖИЗНИMETA-ANALYSIS OF DEPENDENCE OF THE DEVELOPMENT OF EXPERIMENTAL RENOVASCULAR HYPERTENSION “2 KIDNEYS, 1 CLAMP” ON LIFESTYLE FACTORSКузьменкоН. В.KuzmenkoN. V.

Кузьменко Наталия Владимировна, к.б.н., старший научный сотрудник отдела экспериментальной физиологии и фармакологии; младший научный сотрудник лаборатории биофизики кровообращения

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Nataliya V. Kuzmenko, PhD, Senior Researcher, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Researcher of Blood Circulation  Biophysics Laboratory, Research Educational Institute of Biomedicine

Akkuratova str., 2, Saint Petersburg, 197341

nat.kuzmencko2011@yandex.ruЦырлинВ. А.TsyrlinV. A.

Цырлин Виталий Александрович, д.м.н., профессор, главный научный сотрудник отдела экспериментальной физиологии и фармакологии

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Vitaliy A. Tsyrlin, MD, PhD, DSc, Professor, Chief Researcher, Department of Experimental Physiology and Pharmacology of Preclinical and Translational Research Centre

Akkuratova str., 2, Saint Petersburg, 197341

ПлиссМ. Г.PlissM. G.

Плисс Михаил Гениевич, к.м.н., заведующий отделом экспериментальной физиологии и фармакологии; заведующий лабораторией биофизики кровообращения

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Mikhail G. Pliss, PhD, Head, Department of Experimental Physiology and Pharmacology, Preclinical and Translational Research Centre; Head of Biophysics of Blood Circulation Laboratory, Research Educational Institute of Biomedicine

Akkuratova str., 2, Saint Petersburg, 197341

Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research Centre; Academician I. P. Pavlov First Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian Federation202327082023103183208Copyright © Кузьменко Н.В., Цырлин В.А., Плисс М.Г., 20232023Кузьменко Н.В., Цырлин В.А., Плисс М.Г.Kuzmenko N.V., Tsyrlin V.A., Pliss M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/856

Актуальность. К поддающимся контролю факторам риска развития артериальной гипертензии ВОЗ относит нездоровый рацион питания, недостаточную физическую активность, нарушение режима дня. К настоящему времени в большом количестве экспериментальных исследований на крысах изучено влияние на развитие унилатеральной реноваскулярной гипертензии (УРГ) пищевых добавок (минералов, витаминов, флавоноидов, кофеина, жиров, углеводов), физической активности и терапии мелатонином.Цель. Провести метаанализ исследований, посвященных факторам риска развития УРГ.Материалы и методы. Поиск публикаций осуществлялся в базах PubMed, Scopus, Google Scholar. Всего было отобрано 52 публикации.Результаты. Проведенный нами метаанализ результатов экспериментальных исследований реноваскулярной гипертензии в модели «2 почки, 1 зажим» показывает, что выраженность гипертензии снижается при обогащении диеты калием, а также различными антиоксидантами (витамином С, флавоноидами, мелатонином), уменьшающими окислительный стресс в ишемизированной почке. Кроме того, физическая нагрузка может способствовать снижению АД (артериального давления) при УРГ, но при этом она усиливает гипертрофию миокарда. Не выявлен гипертензивный эффект повышенного потребления хлорида натрия при стенозировании почечной артерии, а также не выявлен какой-либо эффект обогащения диеты кальцием или магнием на развитие УРГ. При этом потребление кофеина существенно увеличивает активность ренина плазмы и АД при УРГ.Заключение. Практически все экспериментальные работы, включенные в наш метаанализ, исследовали влияние факторов на развитие УРГ, но не их эффект в отношении величины АД в хронической стадии УРГ.

Background. According to WHO controllable hypertension risk factors include an unhealthy diet, physical inactivity, and wrong daily routine. To date, a large number of experimental studies in rats have studied the effect on the development of unilateral renovascular hypertension (URH) of dietary supplements (minerals, vitamins, flavonoids, caffeine, fats, carbohydrates), physical activity and melatonin therapy.Objective. To conduct a meta- analysis of studies on risk factors for the development of URH.Design and methods. The search for publications was carried out in the PubMed, Scopus, Google Scholar databases. A total of 52 publications were selected.Results. The severity of hypertension decreases when the diet is enriched with potassium, as well as with various antioxidants (vitamin C, flavonoids, melatonin), which reduce oxidative stress in the ischemic kidney. In addition, physical activity can help reduce blood pressure in URH, but at the same time, it increases myocardial hypertrophy. There was no hypertensive effect of increased sodium chloride intake in renal artery stenosis, and no effect of calcium or magnesium supplementation on the URH development. At the same time, caffeine intake significantly increases plasma renin activity and blood pressure in URH.Conclusion. The majority of experimental studies included in our meta-analysis investigated the influence of factors on the development of URH, but not their effect on blood pressure in the chronic stage of URH.

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The authors declare that there are no conflicts of interest present.