transmedТрансляционная медицинаTranslational Medicine2311-44952410-5155Almazov National Medical Research Centre, Saint Petersburg, Russia10.18705/2311-44952023-10-2-77-87transmed-763Research ArticleЭНДОКРИНОЛОГИЧЕСКИЕ ЗАБОЛЕВАНИЯMETABOLIC DISEASESИзменение факторов роста при синдроме поликистозных яичниковChanges in growth factors in polycystic ovarian syndromehttps://orcid.org/0000-0002-8795-1495ВасюковаЕ. А.VasukovaE. A.

Васюкова Елена Андреевна, младший научный сотрудник НИЛ эндокринных заболеваний у беременных, Институт эндокринологии

Санкт-Петербург

Elena A. Vasukova, Junior Researcher, Research Laboratory of Endocrine Diseases in Pregnancy, Institute of Endocrinology

Saint Petersburg

elenavasukova2@gmail.comЗайковаЕ. К.ZaikovaE. K.

Зайкова Екатерина Константиновна, младший научный сотрудник НИЛ аутоиммунных и аутовоспалительных заболеваний, НЦМУ «Центр персонализированной медицины»

Санкт-Петербург

Ekaterina K. Zaikova, Junior Researcher, Research Laboratory of Autoimmune and Autoinflammatory Diseases, World-Class Research Center for Personalized Medicine

Saint Petersburg

КалининаО. В.KalininaO. V.

Калинина Ольга Викторовна, д.б.н., профессор кафедры лабораторной медицины и генетики, ведущий научный сотрудник НИЛ аутоиммунных и аутовоспалительных заболеваний, НЦМУ «Центр персонализированной медицины»

Санкт-Петербург

Olga V. Kalinina, MD, PhD, Professor, Leading Researcher, Research Laboratory of Autoimmune and Autoinflammatory Diseases, World-Class Research Center for Personalized Medicine

Saint Petersburg

ГореловаИ. В.GorelovaI. V.

Горелова Инга Вадимовна, к.м.н., доцент кафедры акушерства и гинекологии с клиникой

Санкт-Петербург

Inga V. Gorelova, PhD, Associate Professor, Department of Obstetrics and Gynecology with Clinic

Saint Petersburg

ПьяноваИ. В.PyanovaI. V.

Пьянова Ирина Вениаминовна, лаборант-исследователь НИЛ эндокринных заболеваний у беременных, Институт эндокринологии, врач ультразвуковой диагностики, Консультативно-диагностическое отделение Перинатального центра

Санкт-Петербург

Irina V. Pyanova, Research laboratory assistant, Research Laboratory of Endocrine Diseases in Pregnancy, Institute of Endocrinology, Specialist of ultrasound diagnostics in CDD

Saint Petersburg

БогатыреваЕ. В.BogatyrevaE. V.

Богатырева Елена Васильевна, к.м.н., врач акушер-гинеколог, репродуктолог

Санкт-Петербург

Elena V. Bogatyreva, MD, PhD, Obstetriciangynecologist, Reproductive specialist

Saint Petersburg

ВасильеваЕ. Ю.VasilyevaE. Y.

Васильева Елена Юрьевна, заведующая центральной клинико-диагностической лабораторией, врач клинической лабораторной диагностики

Санкт-Петербург

Elena Y. Vasilyeva, Head of Clinical Diagnostic Laboratory, Laboratory Diagnostics Specialist

Saint Petersburg

КокинаМ. А.KokinaM. A.

Кокина Мария Александровна, младший научный сотрудник НИЛ метаболических заболеваний и микробиоты, НЦМУ «Центр персонализированной медицины»

Санкт-Петербург

Maria A. Kokina, Junior Researcher, Research Laboratory of Metabolic Disorders and Microbiota, Department of Genetic Risks and Personalized Prevention, World-Class Research Center for Personalized Medicine

Saint Petersburg

ГриневаЕ. Н.GrinevaE. N.

Гринева Елена Николаевна, д.м.н., профессор, член-корреспондент РАН, главный внештатный специалист-эндокринолог по Северо-Западному федеральному округу, директор Института эндокринологии, заведующий кафедрой эндокринологии Института медицинского образования

Санкт-Петербург

Elena N. Grineva, MD, PhD, Professor, the Chief endocrinologist of the North-West Federal District, Director of Endocrinology Institute

Saint Petersburg

ПоповаП. В.PopovaP. V.

Попова Полина Викторовна, к.м.н., заведующий НИЛ метаболических заболеваний и микробиоты, НЦМУ «Центр персонализированной медицины»

ул. Аккуратова, д. 2, Санкт-Петербург, 197341

Polina V. Popova, PhD, Head of the Research Laboratory of Metabolic Disorders and Microbiota, Department of Genetic Risks and Personalized Prevention, World-Class Research Center for Personalized Medicine

Akkuratova str., 2, Saint Petersburg, 197341

pvpopova@yandex.ruФедеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской ФедерацииРоссияAlmazov National Medical Research CentreRussian FederationОбщество с ограниченной ответственностью «АВА-ПЕТЕР»Russian FederationLimited Liability Company AVA-PETERRussian Federation2023200520231027787Copyright © Васюкова Е.А., Зайкова Е.К., Калинина О.В., Горелова И.В., Пьянова И.В., Богатырева Е.В., Васильева Е.Ю., Кокина М.А., Гринева Е.Н., Попова П.В., 20232023Васюкова Е.А., Зайкова Е.К., Калинина О.В., Горелова И.В., Пьянова И.В., Богатырева Е.В., Васильева Е.Ю., Кокина М.А., Гринева Е.Н., Попова П.В.Vasukova E.A., Zaikova E.K., Kalinina O.V., Gorelova I.V., Pyanova I.V., Bogatyreva E.V., Vasilyeva E.Y., Kokina M.A., Grineva E.N., Popova P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://transmed.almazovcentre.ru/jour/article/view/763Актуальность

Актуальность. Синдром поликистозных яичников (СПКЯ) является наиболее распространенным эндокринным заболеванием, частота которого составляет 10–15 % женщин репродуктивного возраста. СПКЯ часто связан с нарушением углеводного и липидного обмена, сахарным диабетом 2 типа, сердечно-сосудистыми заболеваниями и другими осложнениями. В настоящее время активно изучается роль ангиогенеза в патогенезе СПКЯ.

Цель

Цель. Оценка основных ростовых факторов, влияющих на ангиогенез у пациенток с СПКЯ по сравнению со здоровыми женщинами в подгруппах с нормальной и избыточной массой тела.

Материалы и методы

Материалы и методы. В исследование были включены 45 пациенток с СПКЯ (22 женщины с индексом массы тела (ИМТ) < 25 кг/м2 и 23 женщины с ИМТ > 25 кг/м2) и 45 женщин с нормальной овуляцией (22 женщины с ИМТ < 25 кг/м2 и 23 женщины с ИМТ > 25 кг/м2) (контрольная группа). Семь факторов роста были проанализированы в плазме пациентов.

Результаты

Результаты. По сравнению с контрольной группой, женщины с СПКЯ и нормальным весом имели более высокие уровни эпидермального фактора роста (EGF) (медианы 5,57 и 0 пг/мл, p = 0,040) и лиганд fms-подобной тирозинкиназы 3 (FLT3L) (медианы 5,0 и 2,25 пг/мл, р = 0,018). Фактор роста фибробластов 2 типа (FGF 2) и трансформирующий фактор роста альфа (TGF альфа) были повышены у женщин с СПКЯ по сравнению с контрольной группой независимо от наличия/отсутствия избыточной массы тела/ожирения (p < 0,001).

Заключение

Заключение. В группах с избыточной массой тела и в группах без избыточной массы тела у женщин с СПКЯ наблюдается увеличение факторов роста.

Background

Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 10-15% of women of reproductive age. PCOS is often associated with metabolic disorders, type 2 diabetes, cardiovascular disease, and other complications. In recent years, angiogenesis has been widely discussed as an important factor in the pathogenesis of PCOS.

Objective

Objective. To identify growth factors in women with PCOS compared with healthy women in normal and overweight subgroups.

Design and methods

Design and methods. This case-control study carried out at the Almazov National Medical Research Centre (ANMRC) included 45 patients with PCOS (22 women with a body mass index (BMI) < 25 kg/m2 and 23 women with a BMI > 25 kg/m2) and 45 women with normal ovulation (22 women with a BMI < 25 kg/m2 and 23 women with a BMI > 25 kg/m2). Seven growth factors were analyzed in the plasma of patients.

Results

Results. Compared to the control group, normal weight women with PCOS had higher plasma levels of EGF (medians were 5.57 and 0 pg/ml, p = 0.040) and FLT3L (medians were 5.0 and 2.25 pg/ml, p = 0.018). Growth factors FGF 2 and TGF alpha were increased in women with PCOS both in overweight and normal weight subgroups (p<0.001).

Conclusion

Conclusion. In both overweight and non-overweight groups, women with PCOS show an increase in growth factors.

цитокиныEGFFGF2FLT3LPCOSPDGF AAPDGF AB/BBTNF-αVEGF AcytokinesEGFFGF2FLT3LPCOSPDGF AAPDGF AB/BBTNF-αVEGF AИсследование выполнено при поддержке следующего источника: государственное задание № 25, регистрационный номер 121031100288-5. Кроме того, для решения задач по сравнению цитокинового профиля у женщин с СПКЯ и контрольной группы использованы образцы из коллекции, собранной от участниц исследования «Изучение влияния разных способов снижения веса на фертильность и микробиом женщин с ожирением и СПКЯ», выполненного в 2018–2020 гг.The study was carried out with the support of the following source: State assignment No. 25, registration number 121031100288-5. 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The authors declare that there are no conflicts of interest present.