References

transmed

Трансляционная медицина

Translational Medicine

2311-44952410-5155

Almazov National Medical Research Centre, Saint Petersburg, Russia

10.18705/2311-4495-2015-0-2-3-90-97

transmed-74

Research Article

ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ

EXPERIMENTAL STUDIES

Экспериментальные модели изучения механизмов острой реакции трансплантат против хозяина (РтПх) на грызунах

Review of experimental animal models to study mechanisms of acute graft versus host disease (GVHD)

Бутылин

Павел Андреевич

Butylin

butylin_pa@almazovcentre.ru

Бадаев

Ренат Шамилевич

Badaev

R. .

noemail@neicon.ru

Моторин

Дмитрий Васильевич

Motorin

D. .

noemail@neicon.ru

Федеральное государственное бюджетное учреждение «Северо-Западный федеральный медицинский исследовательский центр»РоссияFederal Almazov North-West Research CentreRussian Federation

2015

23122016

02-39097

2016

Бутылин П.А., Бадаев Р.Ш., Моторин Д.В.

Butylin P., Badaev R..., Motorin D...

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://transmed.almazovcentre.ru/jour/article/view/74

Трансплантация гемопоэтических стволовых клеток - необходимая, и подчас единственная возможность излечения для многих пациентов с онкогематологическими заболеваниями. Современное развитие медицинских технологий всё больше расширяет спектр показаний к аллогенной трансплантации ГСК. Наряду с успехами в проведении трансплантаций остаются нерешенными ряд вопросов, касающихся осложнений после трансплантации. Одним из основных осложнений при аллогенной ТГСК является развитие имунного конфликта между клетками донора и тканями реципиента, получившего название реакции трансплантат против хозяина (РТПХ). Ключевые исследования механизмов РТПХ проводятся на модельных животных, в первую очередь на трансгенных мышах. Данный обзор посвящен обзору исследовательских моделей острой РТПХ, использование которых позволяет расширить знания о патогененезе этого явления и исследовать новые терапевтические схемы.

Hematopoietic stem cell transplantation (HSCT) is a necessary and sometimes the only available treatment for the many of the patients with hematological neoplasms. Development of the technologies and protocols for allows broadening of the spectrum of patients that could be treated with allogenic HSCT. One of the main complications in allogenic HSCT is immune conflict of the donor cells with patient’s tissues, named graft versus host disease (GVHD). Key studies of the mechanisms of GVHD are made in experimental models of transplantation in transgenic mice. This paper review current models of acute GVHD that helps to study mechanisms of GVHD and develop new therapeutic schemes to improve efficiency, decrease adverse effects and improving overall survival rate.

аллогенная пересадка гемопоэтических стволовых клеток (алло ТГСК)реакция трансплантат против хозяина (РТПХ)ксеногенная трансплантацияэкспериментальные моделииммунодефицитные мышиallogeneic transplantation of hematopoietic stem cells (ALLO HSCT)graft-versus-host disease (GVHD)xenogeneic transplantationexperimental modelsimmunodeficient mice

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The authors declare that there are no conflicts of interest present.